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• W2102034886 abstract "ABSTRACT Very little is understood regarding how transcription is initiated/regulated in the early-diverging eukaryote Trypanosoma cruzi . Unusually for a eukaryote, genes transcribed by RNA polymerase (Pol) II in T. cruzi are arranged in polycistronic transcription units (PTUs). On the basis of this gene organization, it was previously thought that trypanosomes rely solely on posttranscriptional processes to regulate gene expression. We recently localized a novel glucosylated thymine DNA base, called base J, to potential promoter regions of PTUs throughout the trypanosome genome. Loss of base J, following the deletion of JBP1, a thymidine hydroxylase involved with synthesis, led to a global increase in the Pol II transcription rate and gene expression. In order to determine the mechanism by which base J regulates transcription, we have characterized changes in chromatin structure and Pol II recruitment to promoter regions following the loss of base J. The loss of base J coincides with a decrease in nucleosome abundance, increased histone H3/H4 acetylation, and increased Pol II occupancy at promoter regions, including the well-characterized spliced leader RNA gene promoter. These studies present the first direct evidence for epigenetic regulation of Pol II transcription initiation via DNA modification and chromatin structure in kinetoplastids as well as provide a mechanism for regulation of trypanosome gene expression via the novel hypermodified base J." @default.
• W2102034886 created "2016-06-24" @default.
• W2102034886 creator A5062819006 @default.
• W2102034886 creator A5071269350 @default.
• W2102034886 date "2011-11-01" @default.
• W2102034886 modified "2023-09-27" @default.
• W2102034886 title "Epigenetic Regulation of Polymerase II Transcription Initiation in Trypanosoma cruzi: Modulation of Nucleosome Abundance, Histone Modification, and Polymerase Occupancy by O-Linked Thymine DNA Glucosylation" @default.
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• W2102034886 doi "https://doi.org/10.1128/ec.05185-11" @default.
• W2102034886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3209055" @default.
• W2102034886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21926332" @default.
• W2102034886 hasPublicationYear "2011" @default.
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