Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102040587> ?p ?o ?g. }
- W2102040587 endingPage "970" @default.
- W2102040587 startingPage "959" @default.
- W2102040587 abstract "Abstract HER2 (or ErbB2), a member of ErbB receptor tyrosine kinases, is overexpressed in approximately 20% of human breast cancer, and the ErbB2 signaling pathway is a critical therapeutic target for ErbB2-overexpressing breast cancer. We investigated the inhibitory effects of the Gemini vitamin D analog BXL0124, the synthetic triterpenoid CDDO-Im and the combination on the tumorigenesis of ErbB2-overexpressing breast cancer. MMTV-ErbB2/neu transgenic mice were treated with BXL0124, CDDO-Im, or the combination from three months of age until the end of the experiment. Formation and growth of MMTV-ErbB2/neu mammary tumors were monitored every week, and all three treatments delayed the development of mammary tumors without significant toxicity. Decreased activation of ErbB2 as well as other ErbB receptors, ErbB1 and ErbB3, in MMTV-ErbB2/neu mammary tumors was shown by all treatments. Protein levels of downstream targets of the ErbB2 signaling pathway, including activated-Erk1/2, activated-Akt, c-Myc, CycD1, and Bcl2, were repressed by all three treatments, with the combination treatment exhibiting the strongest effects. To investigate therapeutic efficacy, the combination of BXL0124 and CDDO-Im was given to MMTV-ErbB2/neu mice after mammary tumors were established between 23 and 30 weeks of age. Short-term treatment with the combination did not show effects on tumor growth nor the ErbB2 signaling pathway. The present study shows BXL0124, CDDO-Im, and the combination as potential agents for prevention, but not treatment, against the tumorigenesis of ErbB2-overexpressing breast cancer. Cancer Prev Res; 6(9); 959–70. ©2013 AACR." @default.
- W2102040587 created "2016-06-24" @default.
- W2102040587 creator A5012792790 @default.
- W2102040587 creator A5019578505 @default.
- W2102040587 creator A5021332198 @default.
- W2102040587 creator A5031341481 @default.
- W2102040587 creator A5034479183 @default.
- W2102040587 creator A5042570390 @default.
- W2102040587 creator A5059532915 @default.
- W2102040587 creator A5060635563 @default.
- W2102040587 creator A5071190557 @default.
- W2102040587 creator A5075914077 @default.
- W2102040587 creator A5087595760 @default.
- W2102040587 date "2013-09-01" @default.
- W2102040587 modified "2023-09-28" @default.
- W2102040587 title "Oral Administration of a Gemini Vitamin D Analog, a Synthetic Triterpenoid and the Combination Prevents Mammary Tumorigenesis Driven by ErbB2 Overexpression" @default.
- W2102040587 cites W1964321121 @default.
- W2102040587 cites W1966060541 @default.
- W2102040587 cites W1967244419 @default.
- W2102040587 cites W1974024530 @default.
- W2102040587 cites W1979287544 @default.
- W2102040587 cites W1996023050 @default.
- W2102040587 cites W2000178617 @default.
- W2102040587 cites W2000269004 @default.
- W2102040587 cites W2006381191 @default.
- W2102040587 cites W2014477737 @default.
- W2102040587 cites W2015253178 @default.
- W2102040587 cites W2018407791 @default.
- W2102040587 cites W2026644677 @default.
- W2102040587 cites W2040142253 @default.
- W2102040587 cites W2040856720 @default.
- W2102040587 cites W2044695669 @default.
- W2102040587 cites W2045069049 @default.
- W2102040587 cites W2057716292 @default.
- W2102040587 cites W2060304397 @default.
- W2102040587 cites W2085848947 @default.
- W2102040587 cites W2105061544 @default.
- W2102040587 cites W2115369621 @default.
- W2102040587 cites W2118198101 @default.
- W2102040587 cites W2120913071 @default.
- W2102040587 cites W2129626942 @default.
- W2102040587 cites W2134806649 @default.
- W2102040587 cites W2135017544 @default.
- W2102040587 cites W2137044421 @default.
- W2102040587 cites W2137058900 @default.
- W2102040587 cites W2138167831 @default.
- W2102040587 cites W2140324919 @default.
- W2102040587 cites W2145161910 @default.
- W2102040587 cites W2147872600 @default.
- W2102040587 cites W2153933760 @default.
- W2102040587 cites W2328470294 @default.
- W2102040587 doi "https://doi.org/10.1158/1940-6207.capr-13-0087" @default.
- W2102040587 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3767182" @default.
- W2102040587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23856074" @default.
- W2102040587 hasPublicationYear "2013" @default.
- W2102040587 type Work @default.
- W2102040587 sameAs 2102040587 @default.
- W2102040587 citedByCount "19" @default.
- W2102040587 countsByYear W21020405872014 @default.
- W2102040587 countsByYear W21020405872015 @default.
- W2102040587 countsByYear W21020405872016 @default.
- W2102040587 countsByYear W21020405872017 @default.
- W2102040587 countsByYear W21020405872018 @default.
- W2102040587 countsByYear W21020405872020 @default.
- W2102040587 countsByYear W21020405872021 @default.
- W2102040587 countsByYear W21020405872022 @default.
- W2102040587 crossrefType "journal-article" @default.
- W2102040587 hasAuthorship W2102040587A5012792790 @default.
- W2102040587 hasAuthorship W2102040587A5019578505 @default.
- W2102040587 hasAuthorship W2102040587A5021332198 @default.
- W2102040587 hasAuthorship W2102040587A5031341481 @default.
- W2102040587 hasAuthorship W2102040587A5034479183 @default.
- W2102040587 hasAuthorship W2102040587A5042570390 @default.
- W2102040587 hasAuthorship W2102040587A5059532915 @default.
- W2102040587 hasAuthorship W2102040587A5060635563 @default.
- W2102040587 hasAuthorship W2102040587A5071190557 @default.
- W2102040587 hasAuthorship W2102040587A5075914077 @default.
- W2102040587 hasAuthorship W2102040587A5087595760 @default.
- W2102040587 hasBestOaLocation W21020405871 @default.
- W2102040587 hasConcept C101544691 @default.
- W2102040587 hasConcept C115456853 @default.
- W2102040587 hasConcept C121608353 @default.
- W2102040587 hasConcept C126322002 @default.
- W2102040587 hasConcept C170493617 @default.
- W2102040587 hasConcept C2776187077 @default.
- W2102040587 hasConcept C2779251935 @default.
- W2102040587 hasConcept C502942594 @default.
- W2102040587 hasConcept C530470458 @default.
- W2102040587 hasConcept C555283112 @default.
- W2102040587 hasConcept C62478195 @default.
- W2102040587 hasConcept C71924100 @default.
- W2102040587 hasConcept C75217442 @default.
- W2102040587 hasConcept C86803240 @default.
- W2102040587 hasConcept C95444343 @default.
- W2102040587 hasConceptScore W2102040587C101544691 @default.
- W2102040587 hasConceptScore W2102040587C115456853 @default.
- W2102040587 hasConceptScore W2102040587C121608353 @default.
- W2102040587 hasConceptScore W2102040587C126322002 @default.