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- W2102044971 endingPage "157" @default.
- W2102044971 startingPage "145" @default.
- W2102044971 abstract "Background: Cystic fibrosis (CF) is a lethal hereditary disease characterised by neutrophil-dominated lung inflammation. These abundant neutrophils produce neutrophil elastase (NE), a destructive serine protease that has direct actions on extracellular matrix proteins and has a role in the host response to inflammation and infection. Objective: This review examines the prospect of developing novel therapies for CF by targeting NE. The authors explore the functions of NE and of naturally-occurring and synthetic NE inhibitors. Methods: A literature search was conducted exploring the functions of NE and inhibitors of NE; naturally occurring and synthetic. Conclusions: Targeting NE in CF offers therapeutic potential, but optimal inhibitors that can be delivered safely and effectively to the lung are still under development." @default.
- W2102044971 created "2016-06-24" @default.
- W2102044971 creator A5010132411 @default.
- W2102044971 creator A5034535949 @default.
- W2102044971 creator A5064569516 @default.
- W2102044971 date "2008-01-22" @default.
- W2102044971 modified "2023-09-27" @default.
- W2102044971 title "Targeting neutrophil elastase in cystic fibrosis" @default.
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