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- W2102048152 abstract "Summary Background The cancer risk of low‐grade dysplasia (LGD) in chronic ulcerative colitis is variable and its management remain contentious. Aim To determine the risk of cancer or any advanced lesion once LGD is diagnosed. Methods A MEDLINE, EMBASE and Pub Med search was conducted using the key words ‘surveillance’, ‘colorectal cancer’, ‘low‐grade dysplasia’ and ‘ulcerative colitis’. A random effects model of meta‐analysis was used. Results Twenty surveillance studies had 508 flat LGD or LGD with dysplasia‐associated lesion or mass. An average of 4.3 colonoscopies was performed/patient post‐LGD diagnosis (range: 3–7.6). An average of 18 biopsies taken per colonoscopy (range: 9–24) detected 73 advanced lesions (cancer or high‐grade dysplasia) pre‐operatively. The cancer incidence was 14 of 1000 (95% CI: 5.0–34) person years duration (pyd) and the incidence of any advanced lesion was 30 of 1000 pyd (95% CI: 12–76). When LGD is detected on surveillance there is a ninefold risk of developing cancer (OR: 9.0, 95% CI: 4.0–20.5) and 12‐fold risk of developing any advanced lesion (OR: 11.9, 95% CI: 5.2–27). Conclusions The risk of developing cancer in patients with LGD is high. These estimates are valuable for decision‐making when LGD is encountered on surveillance." @default.
- W2102048152 created "2016-06-24" @default.
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- W2102048152 date "2007-01-22" @default.
- W2102048152 modified "2023-10-17" @default.
- W2102048152 title "Meta-analysis: cancer risk of low-grade dysplasia in chronic ulcerative colitis" @default.
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- W2102048152 doi "https://doi.org/10.1111/j.1365-2036.2007.03241.x" @default.
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