Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102055830> ?p ?o ?g. }
- W2102055830 endingPage "500" @default.
- W2102055830 startingPage "500" @default.
- W2102055830 abstract "<h3>Objective</h3> To determine if loss of protein kinase Cγ (PKCγ) results in increased structural damage to the retina by hyperbaric oxygen (HBO), a treatment used for several ocular disorders. <h3>Methods</h3> Six-week-old mice were exposed in vivo to 100% HBO 3 times a week for 8 weeks. Eyes were dissected, fixed, embedded in Epon, sectioned, stained with toluidine blue O, and examined by light microscopy. <h3>Results</h3> The thicknesses of the inner nuclear and ganglion cell layers were increased. Destruction of the outer plexiform layer was observed in the retinas of the PKCγ-knockout mice relative to control mice. Exposure to HBO caused significant degradation of the retina in knockout mice compared with control mice. Damage to the outer segments of the photoreceptor layer and ganglion cell layer was apparent in central retinas of HBO-treated knockout mice. <h3>Conclusions</h3> Protein kinase Cγ–knockout mice had increased retinal sensitivity to HBO. Results demonstrate that PKCγ protects retinas from HBO damage. <h3>Clinical Relevance</h3> Care should be taken in treating patients with HBO, particularly if they have a genetic disease, such as spinocerebellar ataxia type 14, a condition in which the PKCγ is mutated and nonfunctional." @default.
- W2102055830 created "2016-06-24" @default.
- W2102055830 creator A5017782703 @default.
- W2102055830 creator A5028137347 @default.
- W2102055830 creator A5034755663 @default.
- W2102055830 creator A5045125525 @default.
- W2102055830 creator A5057563740 @default.
- W2102055830 creator A5057768473 @default.
- W2102055830 creator A5075937768 @default.
- W2102055830 creator A5077786122 @default.
- W2102055830 creator A5082187794 @default.
- W2102055830 date "2009-04-13" @default.
- W2102055830 modified "2023-09-27" @default.
- W2102055830 title "Loss of Protein Kinase Cγ in Knockout Mice and Increased Retinal Sensitivity to Hyperbaric Oxygen" @default.
- W2102055830 cites W1515744395 @default.
- W2102055830 cites W1547554564 @default.
- W2102055830 cites W1966479392 @default.
- W2102055830 cites W1974634641 @default.
- W2102055830 cites W1976151026 @default.
- W2102055830 cites W1979566344 @default.
- W2102055830 cites W1982233898 @default.
- W2102055830 cites W1985198185 @default.
- W2102055830 cites W1986662190 @default.
- W2102055830 cites W1989991128 @default.
- W2102055830 cites W1992681894 @default.
- W2102055830 cites W1996051159 @default.
- W2102055830 cites W2005790515 @default.
- W2102055830 cites W2007133363 @default.
- W2102055830 cites W2015984985 @default.
- W2102055830 cites W2019156585 @default.
- W2102055830 cites W2019163121 @default.
- W2102055830 cites W2019857777 @default.
- W2102055830 cites W2023548304 @default.
- W2102055830 cites W2023730968 @default.
- W2102055830 cites W2028450632 @default.
- W2102055830 cites W2029662061 @default.
- W2102055830 cites W2031040394 @default.
- W2102055830 cites W2034771536 @default.
- W2102055830 cites W2037705308 @default.
- W2102055830 cites W2040283281 @default.
- W2102055830 cites W2049562660 @default.
- W2102055830 cites W2049977123 @default.
- W2102055830 cites W2055138121 @default.
- W2102055830 cites W2055662091 @default.
- W2102055830 cites W2058670510 @default.
- W2102055830 cites W2059261191 @default.
- W2102055830 cites W2064467597 @default.
- W2102055830 cites W2065853098 @default.
- W2102055830 cites W2072011163 @default.
- W2102055830 cites W2075822428 @default.
- W2102055830 cites W2082818638 @default.
- W2102055830 cites W2089475281 @default.
- W2102055830 cites W2092474526 @default.
- W2102055830 cites W2095407114 @default.
- W2102055830 cites W2099984156 @default.
- W2102055830 cites W2102544386 @default.
- W2102055830 cites W2112462409 @default.
- W2102055830 cites W2113775635 @default.
- W2102055830 cites W2114070275 @default.
- W2102055830 cites W2117435431 @default.
- W2102055830 cites W2126502788 @default.
- W2102055830 cites W2134454787 @default.
- W2102055830 cites W2135087635 @default.
- W2102055830 cites W2137065941 @default.
- W2102055830 cites W2138700374 @default.
- W2102055830 cites W2139542466 @default.
- W2102055830 cites W2150414697 @default.
- W2102055830 cites W2151532858 @default.
- W2102055830 cites W2153283555 @default.
- W2102055830 cites W2155236757 @default.
- W2102055830 cites W2162073916 @default.
- W2102055830 cites W2165923721 @default.
- W2102055830 cites W2409303234 @default.
- W2102055830 cites W2413943116 @default.
- W2102055830 doi "https://doi.org/10.1001/archophthalmol.2009.31" @default.
- W2102055830 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2702999" @default.
- W2102055830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19365031" @default.
- W2102055830 hasPublicationYear "2009" @default.
- W2102055830 type Work @default.
- W2102055830 sameAs 2102055830 @default.
- W2102055830 citedByCount "8" @default.
- W2102055830 countsByYear W21020558302013 @default.
- W2102055830 countsByYear W21020558302017 @default.
- W2102055830 countsByYear W21020558302020 @default.
- W2102055830 countsByYear W21020558302023 @default.
- W2102055830 crossrefType "journal-article" @default.
- W2102055830 hasAuthorship W2102055830A5017782703 @default.
- W2102055830 hasAuthorship W2102055830A5028137347 @default.
- W2102055830 hasAuthorship W2102055830A5034755663 @default.
- W2102055830 hasAuthorship W2102055830A5045125525 @default.
- W2102055830 hasAuthorship W2102055830A5057563740 @default.
- W2102055830 hasAuthorship W2102055830A5057768473 @default.
- W2102055830 hasAuthorship W2102055830A5075937768 @default.
- W2102055830 hasAuthorship W2102055830A5077786122 @default.
- W2102055830 hasAuthorship W2102055830A5082187794 @default.
- W2102055830 hasBestOaLocation W21020558302 @default.
- W2102055830 hasConcept C105702510 @default.
- W2102055830 hasConcept C126322002 @default.