Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102059453> ?p ?o ?g. }
- W2102059453 abstract "During meiotic cell-cycle progression, unequal divisions take place, resulting in a large oocyte and two diminutive polar bodies. The first polar body contains a subset of bivalent chromosomes, whereas the second polar body contains a haploid set of chromatids. One unique feature of the female gamete is that the polar bodies can provide beneficial information about the genetic background of the oocyte without potentially destroying it. Therefore, polar body biopsies have been applied in preimplantation genetic diagnosis to detect chromosomal or genetic abnormalities that might be inherited by the offspring. Besides the traditional use in preimplantation diagnosis, recent findings suggest additional important roles for polar bodies in assisted reproductive technology. In this paper, we review the new roles of polar bodies in assisted reproductive technology, mainly focusing on single-cell sequencing of the polar body genome to deduce the genomic information of its sibling oocyte and on polar body transfer to prevent the transmission of mtDNA-associated diseases. We also discuss additional potential roles for polar bodies and related key questions in human reproductive health. We believe that further exploration of new roles for polar bodies will contribute to a better understanding of reproductive health and that polar body manipulation and diagnosis will allow production of a greater number of healthy babies." @default.
- W2102059453 created "2016-06-24" @default.
- W2102059453 creator A5033785543 @default.
- W2102059453 creator A5036569823 @default.
- W2102059453 creator A5040008062 @default.
- W2102059453 creator A5052878834 @default.
- W2102059453 creator A5068736733 @default.
- W2102059453 date "2015-01-01" @default.
- W2102059453 modified "2023-09-23" @default.
- W2102059453 title "Polar Bodies in Assisted Reproductive Technology: Current Progress and Future Perspectives1" @default.
- W2102059453 cites W1487359649 @default.
- W2102059453 cites W1529934215 @default.
- W2102059453 cites W1963825171 @default.
- W2102059453 cites W1967058526 @default.
- W2102059453 cites W1968408636 @default.
- W2102059453 cites W1972072347 @default.
- W2102059453 cites W1975030943 @default.
- W2102059453 cites W1979025775 @default.
- W2102059453 cites W1982516282 @default.
- W2102059453 cites W1983164651 @default.
- W2102059453 cites W1987754412 @default.
- W2102059453 cites W1988876420 @default.
- W2102059453 cites W1990132298 @default.
- W2102059453 cites W1992679265 @default.
- W2102059453 cites W1994558154 @default.
- W2102059453 cites W1996943057 @default.
- W2102059453 cites W1997666780 @default.
- W2102059453 cites W2000454435 @default.
- W2102059453 cites W2002460146 @default.
- W2102059453 cites W2004691787 @default.
- W2102059453 cites W2008625611 @default.
- W2102059453 cites W2009978569 @default.
- W2102059453 cites W2010271437 @default.
- W2102059453 cites W2010324884 @default.
- W2102059453 cites W2010659210 @default.
- W2102059453 cites W2010765881 @default.
- W2102059453 cites W2011116207 @default.
- W2102059453 cites W2011238217 @default.
- W2102059453 cites W2011615962 @default.
- W2102059453 cites W2015710217 @default.
- W2102059453 cites W2018221132 @default.
- W2102059453 cites W2024951366 @default.
- W2102059453 cites W2030086060 @default.
- W2102059453 cites W2030794145 @default.
- W2102059453 cites W2036140173 @default.
- W2102059453 cites W2037818631 @default.
- W2102059453 cites W2040244476 @default.
- W2102059453 cites W2040553259 @default.
- W2102059453 cites W2041744767 @default.
- W2102059453 cites W2043294213 @default.
- W2102059453 cites W2044282102 @default.
- W2102059453 cites W2052205195 @default.
- W2102059453 cites W2052865863 @default.
- W2102059453 cites W2054252239 @default.
- W2102059453 cites W2056885612 @default.
- W2102059453 cites W2058470179 @default.
- W2102059453 cites W2063371306 @default.
- W2102059453 cites W2064658390 @default.
- W2102059453 cites W2064977507 @default.
- W2102059453 cites W2065234142 @default.
- W2102059453 cites W2065652778 @default.
- W2102059453 cites W2071252135 @default.
- W2102059453 cites W2073122969 @default.
- W2102059453 cites W2079092251 @default.
- W2102059453 cites W2084279635 @default.
- W2102059453 cites W2085314753 @default.
- W2102059453 cites W2087034915 @default.
- W2102059453 cites W2092491900 @default.
- W2102059453 cites W2094832206 @default.
- W2102059453 cites W2097218762 @default.
- W2102059453 cites W2098463777 @default.
- W2102059453 cites W2098890132 @default.
- W2102059453 cites W2100443132 @default.
- W2102059453 cites W2106208837 @default.
- W2102059453 cites W2107202213 @default.
- W2102059453 cites W2109389832 @default.
- W2102059453 cites W2111041757 @default.
- W2102059453 cites W2121286926 @default.
- W2102059453 cites W2125609206 @default.
- W2102059453 cites W2125624383 @default.
- W2102059453 cites W2128418481 @default.
- W2102059453 cites W2130881804 @default.
- W2102059453 cites W2132147408 @default.
- W2102059453 cites W2136680615 @default.
- W2102059453 cites W2136943393 @default.
- W2102059453 cites W2143262731 @default.
- W2102059453 cites W2144085812 @default.
- W2102059453 cites W2144373769 @default.
- W2102059453 cites W2144534399 @default.
- W2102059453 cites W2147443412 @default.
- W2102059453 cites W2148296422 @default.
- W2102059453 cites W2151595196 @default.
- W2102059453 cites W2151661502 @default.
- W2102059453 cites W2153201108 @default.
- W2102059453 cites W2157246470 @default.
- W2102059453 cites W2160473082 @default.
- W2102059453 cites W2164550220 @default.
- W2102059453 cites W2165474932 @default.
- W2102059453 cites W2166433761 @default.
- W2102059453 cites W2167440444 @default.