FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102077816> ?p ?o ?g. }

• W2102077816 endingPage "452" @default.
• W2102077816 startingPage "446" @default.
• W2102077816 abstract "MDL 62,873 is an amide derivative of teicoplanin A2-2. Like those of natural glycopeptides, its antibacterial activity is mediated by inhibition of cell wall peptidoglycan synthesis. Against streptococci and enterococci, the in vitro activity of MDL 62,873 was similar to that of teicoplanin and greater than that of vancomycin. Against staphylococci, it has activity similar to that of vancomycin, and it was significantly more active than teicoplanin against coagulase-negative isolates. Like teicoplanin and vancomycin, MDL 62,873 had slow but significant bactericidal activity (99 to 99.9% killing in 24 h) against staphylococci at concentrations near the MIC. In murine septicemia studies with Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae, the 50% effective doses were lower than those of vancomycin. In staphylococcal endocarditis in rats, MDL 62,873 at 20 mg/kg of body weight and vancomycin at 40 mg/kg, both doses given intravenously twice daily, had similar efficacies in reducing the heart bacterial load. These results probably reflect the longer half-life of MDL 62,873, which has a pharmacokinetic profile in rats similar to that of teicoplanin." @default.
• W2102077816 created "2016-06-24" @default.
• W2102077816 creator A5005545528 @default.
• W2102077816 creator A5014085008 @default.
• W2102077816 creator A5028297270 @default.
• W2102077816 creator A5044048279 @default.
• W2102077816 creator A5051074036 @default.
• W2102077816 creator A5062072041 @default.
• W2102077816 creator A5069196491 @default.
• W2102077816 creator A5086773617 @default.
• W2102077816 creator A5087066192 @default.
• W2102077816 date "1992-02-01" @default.
• W2102077816 modified "2023-09-27" @default.
• W2102077816 title "Antimicrobial activity of MDL 62,873, a semisynthetic derivative of teicoplanin, in vitro and in experimental infections" @default.
• W2102077816 cites W1510228771 @default.
• W2102077816 cites W1901734092 @default.
• W2102077816 cites W1973299721 @default.
• W2102077816 cites W1978047738 @default.
• W2102077816 cites W1978749677 @default.
• W2102077816 cites W1987002841 @default.
• W2102077816 cites W1994313531 @default.
• W2102077816 cites W2001847772 @default.
• W2102077816 cites W2002030708 @default.
• W2102077816 cites W2002133271 @default.
• W2102077816 cites W2009889907 @default.
• W2102077816 cites W2012165681 @default.
• W2102077816 cites W2015425189 @default.
• W2102077816 cites W2023518339 @default.
• W2102077816 cites W2023957234 @default.
• W2102077816 cites W2058215092 @default.
• W2102077816 cites W2060956416 @default.
• W2102077816 cites W2062398891 @default.
• W2102077816 cites W2072565575 @default.
• W2102077816 cites W2088277597 @default.
• W2102077816 cites W2093081110 @default.
• W2102077816 cites W2098835431 @default.
• W2102077816 cites W2132467192 @default.
• W2102077816 cites W2136167568 @default.
• W2102077816 cites W2502670554 @default.
• W2102077816 cites W2615510468 @default.
• W2102077816 doi "https://doi.org/10.1128/aac.36.2.446" @default.
• W2102077816 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/188455" @default.
• W2102077816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1534978" @default.
• W2102077816 hasPublicationYear "1992" @default.
• W2102077816 type Work @default.
• W2102077816 sameAs 2102077816 @default.
• W2102077816 citedByCount "11" @default.
• W2102077816 crossrefType "journal-article" @default.
• W2102077816 hasAuthorship W2102077816A5005545528 @default.
• W2102077816 hasAuthorship W2102077816A5014085008 @default.
• W2102077816 hasAuthorship W2102077816A5028297270 @default.
• W2102077816 hasAuthorship W2102077816A5044048279 @default.
• W2102077816 hasAuthorship W2102077816A5051074036 @default.
• W2102077816 hasAuthorship W2102077816A5062072041 @default.
• W2102077816 hasAuthorship W2102077816A5069196491 @default.
• W2102077816 hasAuthorship W2102077816A5086773617 @default.
• W2102077816 hasAuthorship W2102077816A5087066192 @default.
• W2102077816 hasBestOaLocation W21020778162 @default.
• W2102077816 hasConcept C137610392 @default.
• W2102077816 hasConcept C185592680 @default.
• W2102077816 hasConcept C2776703206 @default.
• W2102077816 hasConcept C2778980435 @default.
• W2102077816 hasConcept C2779306812 @default.
• W2102077816 hasConcept C2779489039 @default.
• W2102077816 hasConcept C2781253189 @default.
• W2102077816 hasConcept C4937899 @default.
• W2102077816 hasConcept C501593827 @default.
• W2102077816 hasConcept C523546767 @default.
• W2102077816 hasConcept C54355233 @default.
• W2102077816 hasConcept C86803240 @default.
• W2102077816 hasConcept C89423630 @default.
• W2102077816 hasConcept C98274493 @default.
• W2102077816 hasConceptScore W2102077816C137610392 @default.
• W2102077816 hasConceptScore W2102077816C185592680 @default.
• W2102077816 hasConceptScore W2102077816C2776703206 @default.
• W2102077816 hasConceptScore W2102077816C2778980435 @default.
• W2102077816 hasConceptScore W2102077816C2779306812 @default.
• W2102077816 hasConceptScore W2102077816C2779489039 @default.
• W2102077816 hasConceptScore W2102077816C2781253189 @default.
• W2102077816 hasConceptScore W2102077816C4937899 @default.
• W2102077816 hasConceptScore W2102077816C501593827 @default.
• W2102077816 hasConceptScore W2102077816C523546767 @default.
• W2102077816 hasConceptScore W2102077816C54355233 @default.
• W2102077816 hasConceptScore W2102077816C86803240 @default.
• W2102077816 hasConceptScore W2102077816C89423630 @default.
• W2102077816 hasConceptScore W2102077816C98274493 @default.
• W2102077816 hasIssue "2" @default.
• W2102077816 hasLocation W21020778161 @default.
• W2102077816 hasLocation W21020778162 @default.
• W2102077816 hasLocation W21020778163 @default.
• W2102077816 hasOpenAccess W2102077816 @default.
• W2102077816 hasPrimaryLocation W21020778161 @default.
• W2102077816 hasRelatedWork W2009801005 @default.
• W2102077816 hasRelatedWork W2040251555 @default.
• W2102077816 hasRelatedWork W2047404882 @default.
• W2102077816 hasRelatedWork W2126010571 @default.
• W2102077816 hasRelatedWork W2150657480 @default.
• W2102077816 hasRelatedWork W2153012695 @default.

• next