Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102087601> ?p ?o ?g. }
- W2102087601 endingPage "3033" @default.
- W2102087601 startingPage "3023" @default.
- W2102087601 abstract "Abstract p25, a degradation product of p35, has been reported to accumulate in the forebrain of patients with Alzheimer's disease. p25 as well as p35 are activators of cyclin‐dependent kinase 5 (Cdk5) although p25/Cdk5 and p35/Cdk5 complexes have distinct properties. Several mouse models with high levels of p25 expression exhibit signs of neurodegeneration. On the contrary, we have shown that low levels of p25 expression do not cause neurodegeneration and are even beneficial for particular types of learning and memory [Angelo et al ., (2003) Eur J. Neurosci. , 18 , 423–431]. Here, we have studied the influence of low‐level p25 expression in hippocampal synaptic plasticity and in learning and memory for each sex separately in two different genetic backgrounds (129B6F1 and C57BL/6). Surprisingly, we found that low‐level p25 expression had different consequences in male and female mutants. In the two genetic backgrounds LTP induced by a strong stimulation of the Schaffer's collaterals (four trains, 1‐s duration, 5‐min interval) was severely impaired in male, but not in female, p25 mutants. Furthermore, in the two genetic backgrounds spatial learning in the Morris water maze was faster in female p25 mutants than in male transgenic mice. These results suggest that, in women, the production of p25 in Alzheimer's disease could be a compensation for some early learning and memory deficits." @default.
- W2102087601 created "2016-06-24" @default.
- W2102087601 creator A5011627051 @default.
- W2102087601 creator A5012080584 @default.
- W2102087601 creator A5019912016 @default.
- W2102087601 creator A5045353286 @default.
- W2102087601 creator A5051896056 @default.
- W2102087601 creator A5061723479 @default.
- W2102087601 creator A5081786624 @default.
- W2102087601 creator A5085793083 @default.
- W2102087601 date "2005-06-01" @default.
- W2102087601 modified "2023-10-18" @default.
- W2102087601 title "Sexual dimorphisms in the effect of low-level p25 expression on synaptic plasticity and memory" @default.
- W2102087601 cites W1563116834 @default.
- W2102087601 cites W1577397450 @default.
- W2102087601 cites W164492255 @default.
- W2102087601 cites W1653996762 @default.
- W2102087601 cites W1760380374 @default.
- W2102087601 cites W1870692950 @default.
- W2102087601 cites W1937172266 @default.
- W2102087601 cites W1952592959 @default.
- W2102087601 cites W1964830067 @default.
- W2102087601 cites W1971468364 @default.
- W2102087601 cites W1972153963 @default.
- W2102087601 cites W1984704631 @default.
- W2102087601 cites W1989643757 @default.
- W2102087601 cites W1998245695 @default.
- W2102087601 cites W2000335680 @default.
- W2102087601 cites W2000685126 @default.
- W2102087601 cites W2001900724 @default.
- W2102087601 cites W2005576254 @default.
- W2102087601 cites W2007477974 @default.
- W2102087601 cites W2011034665 @default.
- W2102087601 cites W2011573205 @default.
- W2102087601 cites W2013690197 @default.
- W2102087601 cites W2014898742 @default.
- W2102087601 cites W2029817026 @default.
- W2102087601 cites W2030269068 @default.
- W2102087601 cites W2039567064 @default.
- W2102087601 cites W2042346683 @default.
- W2102087601 cites W2048947179 @default.
- W2102087601 cites W2049511526 @default.
- W2102087601 cites W2063540863 @default.
- W2102087601 cites W2068412840 @default.
- W2102087601 cites W2069705491 @default.
- W2102087601 cites W2076172796 @default.
- W2102087601 cites W2085066072 @default.
- W2102087601 cites W2087329033 @default.
- W2102087601 cites W2090521738 @default.
- W2102087601 cites W2090942873 @default.
- W2102087601 cites W2092338494 @default.
- W2102087601 cites W2092765133 @default.
- W2102087601 cites W2098732177 @default.
- W2102087601 cites W2100134781 @default.
- W2102087601 cites W2106787391 @default.
- W2102087601 cites W2112047897 @default.
- W2102087601 cites W2113460545 @default.
- W2102087601 cites W2124173184 @default.
- W2102087601 cites W2129677617 @default.
- W2102087601 cites W2141998004 @default.
- W2102087601 cites W2142349181 @default.
- W2102087601 cites W2147354849 @default.
- W2102087601 cites W2165762516 @default.
- W2102087601 cites W2167415113 @default.
- W2102087601 cites W2168516263 @default.
- W2102087601 doi "https://doi.org/10.1111/j.1460-9568.2005.04137.x" @default.
- W2102087601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15978013" @default.
- W2102087601 hasPublicationYear "2005" @default.
- W2102087601 type Work @default.
- W2102087601 sameAs 2102087601 @default.
- W2102087601 citedByCount "41" @default.
- W2102087601 countsByYear W21020876012012 @default.
- W2102087601 countsByYear W21020876012013 @default.
- W2102087601 countsByYear W21020876012014 @default.
- W2102087601 countsByYear W21020876012016 @default.
- W2102087601 countsByYear W21020876012017 @default.
- W2102087601 countsByYear W21020876012018 @default.
- W2102087601 countsByYear W21020876012019 @default.
- W2102087601 countsByYear W21020876012020 @default.
- W2102087601 countsByYear W21020876012022 @default.
- W2102087601 crossrefType "journal-article" @default.
- W2102087601 hasAuthorship W2102087601A5011627051 @default.
- W2102087601 hasAuthorship W2102087601A5012080584 @default.
- W2102087601 hasAuthorship W2102087601A5019912016 @default.
- W2102087601 hasAuthorship W2102087601A5045353286 @default.
- W2102087601 hasAuthorship W2102087601A5051896056 @default.
- W2102087601 hasAuthorship W2102087601A5061723479 @default.
- W2102087601 hasAuthorship W2102087601A5081786624 @default.
- W2102087601 hasAuthorship W2102087601A5085793083 @default.
- W2102087601 hasConcept C121738310 @default.
- W2102087601 hasConcept C126322002 @default.
- W2102087601 hasConcept C148762608 @default.
- W2102087601 hasConcept C15744967 @default.
- W2102087601 hasConcept C169760540 @default.
- W2102087601 hasConcept C170493617 @default.
- W2102087601 hasConcept C184235292 @default.
- W2102087601 hasConcept C25274449 @default.
- W2102087601 hasConcept C2776925932 @default.