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• W2102087951 abstract "<h3>Objective</h3> As patients with multiple sclerosis (MS) have more than 2.5-fold increased mortality risk, we sought to investigate the impact of tobacco smoking on the risk of premature death and its contribution to the excess mortality in MS patients. <h3>Methods</h3> We studied 1032 patients during the period 1994–2013 in a UK-based register. Cox regression model was used to investigate the impact of smoking on the risk of premature death, controlling for confounders. Smoking-specific mortality rates were compared with the UK general population. <h3>Results</h3> Of 923 patients with clinically definite MS, 80 (46 males and 34 females) had died by December 2012. HRs for death in current smokers and ex-smokers relative to never smokers were 2.70 (95% CI 1.59 to 4.58, p<0.001) and 1.30 (95% CI 0.72 to 2.32; p<i> </i>= 0.37). The standardised mortality ratio, compared with the UK general population, when stratified by smoking status was 3.83 (95% CI 2.71 to 5.42) in current smokers, 1.96 (95% CI 1.27 to 3.0) in ex-smokers and 1.27 (95% CI 0.87 to 1.86) in non-smokers. Never smokers and ex-smokers with MS had similar mortality rates compared with never smokers and ex-smokers without MS in the male British doctors cohort (1.12 (95% CI 0.63 to 1.97) and 0.54 (95% CI 0.26 to 1.14), respectively), while current smokers with MS had 84% higher rate of death compared with current smokers without MS (95% CI 1.24 to 2.72). <h3>Conclusions</h3> Tobacco smoking can account for some of the excess mortality associated with MS and is a risk determinant for all-cause and MS-related death." @default.
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• W2102087951 date "2014-02-25" @default.
• W2102087951 modified "2023-10-17" @default.
• W2102087951 title "Tobacco smoking and excess mortality in multiple sclerosis: a cohort study" @default.
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• W2102087951 doi "https://doi.org/10.1136/jnnp-2013-307187" @default.
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