Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102097595> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2102097595 endingPage "3633" @default.
- W2102097595 startingPage "3627" @default.
- W2102097595 abstract "The human TCR-gamma delta occurs in three biochemically distinct forms (forms 1, 2bc, and 2abc). A 40-kDa TCR gamma-chain is disulfide-linked to the TCR delta-chain in form 1, whereas 40-kDa or 55-kDa TCR-gamma polypeptides are noncovalently associated with the TCR delta-chain in forms 2bc and 2abc, respectively. Sequence analysis of TCR-gamma cDNA clones indicates that form 1 utilizes the C gamma 1 gene segment, whereas forms 2bc and 2abc appear to use allelic C gamma 2 gene segments containing either two copies (b and c) or three copies (a, b, and c) of the CII exon, respectively. We transfected TCR-gamma cDNA encoding form 1 or form 2abc into the MOLT-13 cell line that expresses form 2bc. The transfected TCR gamma-chains associate with the resident MOLT-13 TCR-delta, normally part of form 2bc, to yield CD3-associated TCR-gamma delta heterodimers identical to those seen on the donor cell lines (form 1 or 2abc). These transfection experiments show directly that, 1) when a single TCR-delta subunit is available, the presence or absence of disulfide linkage between TCR gamma- and TCR delta-chains is controlled by the TCR gamma-chain, and 2) the difference in the amount of N-linked carbohydrate attached to the transfected TCR-gamma proteins of form 2bc vs form 2abc is influenced by the presence or absence of CII exon copy a which appears to alter the secondary and/or tertiary structure of these TCR gamma-chain constant regions, thereby affecting the attachment of N-linked glycans. In contrast to the similar structure and usage of C beta 1 and C beta 2, TCR-gamma delta forms show striking differences in structure and are not equally represented in peripheral blood. Although the role of each form is unknown, it is possible that variable or joining-gene segment selection events or functional differences account for their unequal usage." @default.
- W2102097595 created "2016-06-24" @default.
- W2102097595 creator A5000815014 @default.
- W2102097595 creator A5034686039 @default.
- W2102097595 creator A5054888474 @default.
- W2102097595 creator A5066821717 @default.
- W2102097595 creator A5075092692 @default.
- W2102097595 date "1989-05-15" @default.
- W2102097595 modified "2023-10-16" @default.
- W2102097595 title "Expression of human T cell receptor-gamma delta structural forms." @default.
- W2102097595 doi "https://doi.org/10.4049/jimmunol.142.10.3627" @default.
- W2102097595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2785559" @default.
- W2102097595 hasPublicationYear "1989" @default.
- W2102097595 type Work @default.
- W2102097595 sameAs 2102097595 @default.
- W2102097595 citedByCount "8" @default.
- W2102097595 countsByYear W21020975952014 @default.
- W2102097595 countsByYear W21020975952015 @default.
- W2102097595 crossrefType "journal-article" @default.
- W2102097595 hasAuthorship W2102097595A5000815014 @default.
- W2102097595 hasAuthorship W2102097595A5034686039 @default.
- W2102097595 hasAuthorship W2102097595A5054888474 @default.
- W2102097595 hasAuthorship W2102097595A5066821717 @default.
- W2102097595 hasAuthorship W2102097595A5075092692 @default.
- W2102097595 hasBestOaLocation W21020975951 @default.
- W2102097595 hasConcept C104317684 @default.
- W2102097595 hasConcept C114684123 @default.
- W2102097595 hasConcept C147483822 @default.
- W2102097595 hasConcept C153911025 @default.
- W2102097595 hasConcept C167672396 @default.
- W2102097595 hasConcept C187882448 @default.
- W2102097595 hasConcept C19317047 @default.
- W2102097595 hasConcept C2776090121 @default.
- W2102097595 hasConcept C2778794311 @default.
- W2102097595 hasConcept C36823959 @default.
- W2102097595 hasConcept C54009773 @default.
- W2102097595 hasConcept C54355233 @default.
- W2102097595 hasConcept C55493867 @default.
- W2102097595 hasConcept C86803240 @default.
- W2102097595 hasConcept C8891405 @default.
- W2102097595 hasConceptScore W2102097595C104317684 @default.
- W2102097595 hasConceptScore W2102097595C114684123 @default.
- W2102097595 hasConceptScore W2102097595C147483822 @default.
- W2102097595 hasConceptScore W2102097595C153911025 @default.
- W2102097595 hasConceptScore W2102097595C167672396 @default.
- W2102097595 hasConceptScore W2102097595C187882448 @default.
- W2102097595 hasConceptScore W2102097595C19317047 @default.
- W2102097595 hasConceptScore W2102097595C2776090121 @default.
- W2102097595 hasConceptScore W2102097595C2778794311 @default.
- W2102097595 hasConceptScore W2102097595C36823959 @default.
- W2102097595 hasConceptScore W2102097595C54009773 @default.
- W2102097595 hasConceptScore W2102097595C54355233 @default.
- W2102097595 hasConceptScore W2102097595C55493867 @default.
- W2102097595 hasConceptScore W2102097595C86803240 @default.
- W2102097595 hasConceptScore W2102097595C8891405 @default.
- W2102097595 hasIssue "10" @default.
- W2102097595 hasLocation W21020975951 @default.
- W2102097595 hasLocation W21020975952 @default.
- W2102097595 hasOpenAccess W2102097595 @default.
- W2102097595 hasPrimaryLocation W21020975951 @default.
- W2102097595 hasRelatedWork W1479717491 @default.
- W2102097595 hasRelatedWork W2075717222 @default.
- W2102097595 hasRelatedWork W2082500583 @default.
- W2102097595 hasRelatedWork W2084701297 @default.
- W2102097595 hasRelatedWork W2115420598 @default.
- W2102097595 hasRelatedWork W2163104976 @default.
- W2102097595 hasRelatedWork W2352258017 @default.
- W2102097595 hasRelatedWork W2386240997 @default.
- W2102097595 hasRelatedWork W2410597369 @default.
- W2102097595 hasRelatedWork W92985736 @default.
- W2102097595 hasVolume "142" @default.
- W2102097595 isParatext "false" @default.
- W2102097595 isRetracted "false" @default.
- W2102097595 magId "2102097595" @default.
- W2102097595 workType "article" @default.