FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102115309> ?p ?o ?g. }

• W2102115309 endingPage "H2449" @default.
• W2102115309 startingPage "H2440" @default.
• W2102115309 abstract "Fetal to maternal blood flow matching in the placenta, necessary for optimal fetal blood oxygenation, may occur via hypoxic fetoplacental vasoconstriction (HFPV). We hypothesized that HFPV is mediated by K(+) channel inhibition in fetoplacental vascular smooth muscle, as occurs in several other O(2)-sensitive tissues. With the use of an isolated human placental cotyledon perfused at a constant flow rate, we found that hypoxia reversibly increased perfusion pressure by >20%. HFPV was unaffected by cyclooxygenase or nitric oxide synthase inhibition. HFPV and 4-aminopyridine, an inhibitor of voltage-dependent K(+) (K(v)) channels, increased pressure in a nonadditive manner, suggesting they act via a common mechanism. Iberiotoxin, a large conductance Ca(2+)-sensitive K(+) (BK(Ca)) channel inhibitor, had little effect on normoxic pressure. Immunoblotting and RT-PCR showed expression of several putative O(2)-sensitive K(+) channels in peripheral fetoplacental vessels. In patch-clamp experiments with smooth muscle cells isolated from peripheral fetoplacental arteries, hypoxia reversibly inhibited K(v) but not BK(Ca) or ATP-dependent currents. We conclude that human fetoplacental vessels constrict in response to hypoxia. This response is largely mediated by hypoxic inhibition of K(v) channels in the smooth muscle of small fetoplacental arteries." @default.
• W2102115309 created "2016-06-24" @default.
• W2102115309 creator A5016527328 @default.
• W2102115309 creator A5018086781 @default.
• W2102115309 creator A5021152638 @default.
• W2102115309 creator A5023499622 @default.
• W2102115309 creator A5026438725 @default.
• W2102115309 creator A5063467487 @default.
• W2102115309 creator A5089409496 @default.
• W2102115309 date "2002-12-01" @default.
• W2102115309 modified "2023-09-27" @default.
• W2102115309 title "Hypoxic fetoplacental vasoconstriction in humans is mediated by potassium channel inhibition" @default.
• W2102115309 cites W134363133 @default.
• W2102115309 cites W1537220258 @default.
• W2102115309 cites W1753089048 @default.
• W2102115309 cites W1951323910 @default.
• W2102115309 cites W1963548830 @default.
• W2102115309 cites W1966284289 @default.
• W2102115309 cites W1969883174 @default.
• W2102115309 cites W1973033888 @default.
• W2102115309 cites W1988675687 @default.
• W2102115309 cites W1989229224 @default.
• W2102115309 cites W1990285738 @default.
• W2102115309 cites W1996885498 @default.
• W2102115309 cites W2001223885 @default.
• W2102115309 cites W2010371327 @default.
• W2102115309 cites W2013187579 @default.
• W2102115309 cites W2022705084 @default.
• W2102115309 cites W2038098772 @default.
• W2102115309 cites W2039741690 @default.
• W2102115309 cites W2043373424 @default.
• W2102115309 cites W2049414762 @default.
• W2102115309 cites W2050099786 @default.
• W2102115309 cites W2069174503 @default.
• W2102115309 cites W2089288497 @default.
• W2102115309 cites W2095734666 @default.
• W2102115309 cites W2096601431 @default.
• W2102115309 cites W2103857474 @default.
• W2102115309 cites W2125510118 @default.
• W2102115309 cites W2139487480 @default.
• W2102115309 cites W2144709689 @default.
• W2102115309 cites W2145125740 @default.
• W2102115309 cites W2146191063 @default.
• W2102115309 cites W2155920800 @default.
• W2102115309 cites W2173397792 @default.
• W2102115309 cites W2412102427 @default.
• W2102115309 cites W2419767123 @default.
• W2102115309 doi "https://doi.org/10.1152/ajpheart.01033.2001" @default.
• W2102115309 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12388256" @default.
• W2102115309 hasPublicationYear "2002" @default.
• W2102115309 type Work @default.
• W2102115309 sameAs 2102115309 @default.
• W2102115309 citedByCount "92" @default.
• W2102115309 countsByYear W21021153092012 @default.
• W2102115309 countsByYear W21021153092013 @default.
• W2102115309 countsByYear W21021153092014 @default.
• W2102115309 countsByYear W21021153092015 @default.
• W2102115309 countsByYear W21021153092016 @default.
• W2102115309 countsByYear W21021153092018 @default.
• W2102115309 countsByYear W21021153092019 @default.
• W2102115309 countsByYear W21021153092020 @default.
• W2102115309 countsByYear W21021153092021 @default.
• W2102115309 countsByYear W21021153092022 @default.
• W2102115309 countsByYear W21021153092023 @default.
• W2102115309 crossrefType "journal-article" @default.
• W2102115309 hasAuthorship W2102115309A5016527328 @default.
• W2102115309 hasAuthorship W2102115309A5018086781 @default.
• W2102115309 hasAuthorship W2102115309A5021152638 @default.
• W2102115309 hasAuthorship W2102115309A5023499622 @default.
• W2102115309 hasAuthorship W2102115309A5026438725 @default.
• W2102115309 hasAuthorship W2102115309A5063467487 @default.
• W2102115309 hasAuthorship W2102115309A5089409496 @default.
• W2102115309 hasConcept C126322002 @default.
• W2102115309 hasConcept C134018914 @default.
• W2102115309 hasConcept C172680121 @default.
• W2102115309 hasConcept C178790620 @default.
• W2102115309 hasConcept C181199279 @default.
• W2102115309 hasConcept C185592680 @default.
• W2102115309 hasConcept C2776953305 @default.
• W2102115309 hasConcept C2779234561 @default.
• W2102115309 hasConcept C2779395532 @default.
• W2102115309 hasConcept C2779411790 @default.
• W2102115309 hasConcept C2779689624 @default.
• W2102115309 hasConcept C2779961880 @default.
• W2102115309 hasConcept C2992686903 @default.
• W2102115309 hasConcept C519581460 @default.
• W2102115309 hasConcept C540031477 @default.
• W2102115309 hasConcept C54355233 @default.
• W2102115309 hasConcept C55493867 @default.
• W2102115309 hasConcept C71924100 @default.
• W2102115309 hasConcept C7836513 @default.
• W2102115309 hasConcept C83743174 @default.
• W2102115309 hasConcept C86803240 @default.
• W2102115309 hasConceptScore W2102115309C126322002 @default.
• W2102115309 hasConceptScore W2102115309C134018914 @default.
• W2102115309 hasConceptScore W2102115309C172680121 @default.
• W2102115309 hasConceptScore W2102115309C178790620 @default.
• W2102115309 hasConceptScore W2102115309C181199279 @default.

• next