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• W2102151457 abstract "We present a novel method designed to analyze the discriminative ability of knowledge-based potentials with respect to the 20 residue types. The method is based on the preference of amino acids for specific types of protein environment, and uses a virtual mutagenesis experiment to estimate how much information a given potential can provide about environments of each amino acid type. This allows one to test and optimize the performance of real potentials at the level of individual amino acids, using actual data on residue environments from a dataset of known protein structures. We have applied our method to long-range and medium-range pairwise distance-dependent potentials. The results of our study indicate that these potentials are only able to discriminate between a very limited number of residue types, and that discriminative ability is extremely sensitive to the choice of parameters used to construct the potentials, and even to the size of the training dataset. We also show that different types of pairwise distance potentials are dominated by different types of interactions. These dominant interactions strongly depend on the type of approximation used to define residue position. For each potential, our methodology is able to identify a potential-specific amino acid distance matrix and a reduced amino acid alphabet of any specified size, which may have implications for sequence alignment and multibody models." @default.
• W2102151457 created "2016-06-24" @default.
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• W2102151457 creator A5031363135 @default.
• W2102151457 date "2002-09-03" @default.
• W2102151457 modified "2023-09-23" @default.
• W2102151457 title "Discriminative ability with respect to amino acid types: Assessing the performance of knowledge-based potentials without threading" @default.
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• W2102151457 doi "https://doi.org/10.1002/prot.10211" @default.
• W2102151457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12211006" @default.
• W2102151457 hasPublicationYear "2002" @default.
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