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- W2102156555 abstract "Background: SCS has been shown to restore an effective cough mechanism in SCI subjects.Objective: To re-assess the clinical parameters related to use of the cough system in subjects who have had the implant for a minimum of 2 years (mean 4.6±0.6 years), well beyond the period of close follow-up.Outcome Measures: Maximum airway pressure generation (P) and other clinical assessments related to secretion management.Results: Each subject continued to use the device on a regular, usually daily, basis. Pre-implant P was 28±5cmH2O. During SCS, P were 103±20 and 108±23cmH2O at the 1 year and mean 4.60 year follow-up points, respectively (p<0.05 compared to pre-implant and NS when compared to 1 year follow-up during SCS).There were significant improvements in each of the measures related to airway clearance, and the need for alternative methods of secretion removal was virtually eliminated in each subject. The need for trained caregivers to provide other means of secretion management and the incidence of respiratory tract infections remained significantly below the pre-implant values (p<0.05). All subjects reported reduce anxiety and embarrassment related to secretion clearance, greater mobility and consequent improvement in social interaction and improvement in overall life quality.Conclusion: Subjects continued to use the system on a long-term basis beyond the period of close follow-up and to continued derive significant clinical benefits.Support: NIH: NIH-NINDS (R01NS049516 and RC1NS068576), NCRR (M01RR0080 and UL1RR024989).Disclosure: Dr. DiMarco is a Founder of and has a significant financial interest in Synapse BioMedical, Inc, a manufacturer of diaphragm pacing systems." @default.
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- W2102156555 date "2014-09-01" @default.
- W2102156555 modified "2023-09-26" @default.
- W2102156555 title "Spinal cord stimulation (SCS) to restore cough in spinal cord injury (SCI) subjects: Long-term follow-up" @default.
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