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- W2102177890 abstract "Significance Staphylococcus aureus is one of the most successful and adaptable human pathogens and is a major cause of hospital-acquired infections. Here we provide insight into how S . aureus uses the catabolite control protein E (CcpE) to sense its intracellular metabolic status and to regulate its virulence-associated properties. We define a key circuit of the virulence regulatory network of S . aureus and emphasize that metabolic status may be a critical element governing the virulence of this pathogen. Understanding the role of metabolites in virulence factor expression ultimately may contribute to the development of novel strategies to combat this dreaded infectious disease." @default.
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- W2102177890 date "2014-11-03" @default.
- W2102177890 modified "2023-10-18" @default.
- W2102177890 title "Metabolic sensor governing bacterial virulence in <i>Staphylococcus aureus</i>" @default.
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- W2102177890 doi "https://doi.org/10.1073/pnas.1411077111" @default.
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