Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102224211> ?p ?o ?g. }
- W2102224211 endingPage "818" @default.
- W2102224211 startingPage "809" @default.
- W2102224211 abstract "Non-alcoholic fatty liver disease (NAFLD) is a liver pathology with increasing prevalence due to the obesity epidemic. Hence, NAFLD represents a rising threat to public health. Currently, no effective treatments are available to treat NAFLD and its complications such as cirrhosis and liver cancer. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors which regulate lipid and glucose metabolism as well as inflammation. Here we review recent findings on the pathophysiological role of PPARs in the different stages of NAFLD, from steatosis development to steatohepatitis and fibrosis, as well as the preclinical and clinical evidence for potential therapeutical use of PPAR agonists in the treatment of NAFLD. PPARs play a role in modulating hepatic triglyceride accumulation, a hallmark of the development of NAFLD. Moreover, PPARs may also influence the evolution of reversible steatosis toward irreversible, more advanced lesions. Presently, large controlled trials of long duration are needed to assess the long-term clinical benefits of PPAR agonists in humans. This article is part of a Special Issue entitled Triglyceride Metabolism and Disease." @default.
- W2102224211 created "2016-06-24" @default.
- W2102224211 creator A5001127450 @default.
- W2102224211 creator A5074042132 @default.
- W2102224211 creator A5088966082 @default.
- W2102224211 date "2012-05-01" @default.
- W2102224211 modified "2023-09-26" @default.
- W2102224211 title "Roles of PPARs in NAFLD: Potential therapeutic targets" @default.
- W2102224211 cites W1505404389 @default.
- W2102224211 cites W1507343615 @default.
- W2102224211 cites W1522553235 @default.
- W2102224211 cites W1524321743 @default.
- W2102224211 cites W1528348540 @default.
- W2102224211 cites W1530129189 @default.
- W2102224211 cites W1562891630 @default.
- W2102224211 cites W1567127662 @default.
- W2102224211 cites W1574112426 @default.
- W2102224211 cites W1587875569 @default.
- W2102224211 cites W1865180716 @default.
- W2102224211 cites W1963533730 @default.
- W2102224211 cites W1966975625 @default.
- W2102224211 cites W1967972402 @default.
- W2102224211 cites W1973187958 @default.
- W2102224211 cites W1977041568 @default.
- W2102224211 cites W1978805605 @default.
- W2102224211 cites W1984180526 @default.
- W2102224211 cites W1984740688 @default.
- W2102224211 cites W1984825084 @default.
- W2102224211 cites W1985592156 @default.
- W2102224211 cites W1986252060 @default.
- W2102224211 cites W1987892855 @default.
- W2102224211 cites W1989363848 @default.
- W2102224211 cites W1990055069 @default.
- W2102224211 cites W1992319730 @default.
- W2102224211 cites W1993063661 @default.
- W2102224211 cites W1996641308 @default.
- W2102224211 cites W1997978122 @default.
- W2102224211 cites W2000129233 @default.
- W2102224211 cites W2002266832 @default.
- W2102224211 cites W2003053380 @default.
- W2102224211 cites W2003427415 @default.
- W2102224211 cites W2004856128 @default.
- W2102224211 cites W2007582789 @default.
- W2102224211 cites W2008167092 @default.
- W2102224211 cites W2009170266 @default.
- W2102224211 cites W2009715627 @default.
- W2102224211 cites W2014593901 @default.
- W2102224211 cites W2015643123 @default.
- W2102224211 cites W2016661258 @default.
- W2102224211 cites W2018466592 @default.
- W2102224211 cites W2019151036 @default.
- W2102224211 cites W2019280401 @default.
- W2102224211 cites W2019973807 @default.
- W2102224211 cites W2021208588 @default.
- W2102224211 cites W2021304489 @default.
- W2102224211 cites W2022030431 @default.
- W2102224211 cites W2022184946 @default.
- W2102224211 cites W2023461955 @default.
- W2102224211 cites W2025568319 @default.
- W2102224211 cites W2025657436 @default.
- W2102224211 cites W2027889152 @default.
- W2102224211 cites W2028782957 @default.
- W2102224211 cites W2030871051 @default.
- W2102224211 cites W2031054297 @default.
- W2102224211 cites W2032546021 @default.
- W2102224211 cites W2035197720 @default.
- W2102224211 cites W2036136677 @default.
- W2102224211 cites W2037598347 @default.
- W2102224211 cites W2038654926 @default.
- W2102224211 cites W2040538211 @default.
- W2102224211 cites W2045383586 @default.
- W2102224211 cites W2046935888 @default.
- W2102224211 cites W2048183815 @default.
- W2102224211 cites W2052754205 @default.
- W2102224211 cites W2053528170 @default.
- W2102224211 cites W2054800029 @default.
- W2102224211 cites W2059700860 @default.
- W2102224211 cites W2060476304 @default.
- W2102224211 cites W2062663604 @default.
- W2102224211 cites W2062812115 @default.
- W2102224211 cites W2063671857 @default.
- W2102224211 cites W2065624367 @default.
- W2102224211 cites W2067332921 @default.
- W2102224211 cites W2068654524 @default.
- W2102224211 cites W2069412892 @default.
- W2102224211 cites W2070053386 @default.
- W2102224211 cites W2072234373 @default.
- W2102224211 cites W2073625229 @default.
- W2102224211 cites W2076204761 @default.
- W2102224211 cites W2076249810 @default.
- W2102224211 cites W2078176020 @default.
- W2102224211 cites W2080361134 @default.
- W2102224211 cites W2082509181 @default.
- W2102224211 cites W2082702559 @default.
- W2102224211 cites W2083685463 @default.
- W2102224211 cites W2084096026 @default.
- W2102224211 cites W2084212236 @default.
- W2102224211 cites W2086482588 @default.