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• W2102229358 abstract "ABSTRACT Previous studies have established that members of the Mycobacterium tuberculosis complex exhibit variable production of the antigenic proteins MPT70 and MPT83 due to mutations in their positive regulator, SigK (sigma factor K), and their negative regulator, RskA (regulator of sigma K). To further understand this highly specific SigK-controlled regulon, we have undertaken evolutionary studies to determine the presence of homologues of SigK-regulated genes in other organisms and to predict its transcriptional network. Evolutionary analysis indicates that the positive and negative regulators are conserved across many organisms, but that the genes under their control are variable. Moreover, the addition, loss, and movement of various genes in the mpt70/83 locus suggest that these genes are unlikely to be cotranscribed. To test predictions from sequence analysis, we have used promoter luciferase fusions and Northern blots to show that the majority of genes in this locus have their own promoters, of which a subset are SigK regulated ( mpt83 , dipZ , mpt70 , and Rv0449c). Next, we have shown that the intracellular inducibility of mpt70 and mpt83 is a conserved property, shared between M. tuberculosis and Mycobacterium marinum . In addition, we have shown that SigK and RskA from an environmental mycobacterium isolate ( M. gilvum PYR-GCK) complemented the regulatory activity of M. tuberculosis Δ sigK rskA . Together, our data indicate that the regulatory system SigK/RskA is conserved across the Mycobacterium genus, whereas the regulon under its control varies considerably across species." @default.
• W2102229358 created "2016-06-24" @default.
• W2102229358 creator A5044879826 @default.
• W2102229358 creator A5085873422 @default.
• W2102229358 creator A5088232668 @default.
• W2102229358 date "2008-03-15" @default.
• W2102229358 modified "2023-10-18" @default.
• W2102229358 title "Evolution of the Mycobacterial SigK Regulon" @default.
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• W2102229358 doi "https://doi.org/10.1128/jb.01452-07" @default.
• W2102229358 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2258859" @default.
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