Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102234502> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2102234502 endingPage "1515" @default.
- W2102234502 startingPage "1514" @default.
- W2102234502 abstract "Antibody diversity is generated during B cell development by the rearrangement of variable (V), diversity (D), and joining (J) segments of immunoglobulin (Ig) genes. Both alleles of each Ig locus can initiate rearrangement, but only one allele successfully rearranges. As soon as this occurs, the other allele is prevented from following suit. This mechanism, known as allelic exclusion, guarantees that each B cell produces antibodies specific for just one antigen. In her laboratory at New York University (NYU), Jane Skok studies how exclusion is established.Figure 1Jane SkokSkok's initial foray into research involved dissecting the genetics of the complement cascade with Ellen Solomon at Cancer Research UK (1). But immediately after earning her Ph.D., Skok left science to care for her ill child. When she returned nearly a decade later, she had to start from scratch. After getting up to speed with a Master's in immunology, she joined Amanda Fisher's lab, where she gravitated toward B cells and the question of allelic exclusion.Skok has since helped define some of the steps that make exclusion possible. She discovered that the excluded Ig allele gets sent to repressive DNA domains near the centromere, whereas the productive allele remains within accessible domains (2–4). She later focused on one of the more curious aspects of allelic exclusion. During rearrangement, the Ig locus contracts, allowing V, D, and J segments to get close to each other and join up. Skok found that the successful rearrangement of one allele triggers locus relaxation, thereby stopping rearrangement of the other allele (5). She is now hunting for the proteins and pathways that direct the contortion and movement of Ig loci." @default.
- W2102234502 created "2016-06-24" @default.
- W2102234502 creator A5022415292 @default.
- W2102234502 date "2008-07-07" @default.
- W2102234502 modified "2023-09-29" @default.
- W2102234502 title "Jane Skok: Choreography of allelic exclusion" @default.
- W2102234502 cites W1567815100 @default.
- W2102234502 cites W1968554285 @default.
- W2102234502 cites W1995955910 @default.
- W2102234502 cites W2030878215 @default.
- W2102234502 cites W2042398661 @default.
- W2102234502 doi "https://doi.org/10.1084/jem.2057pi" @default.
- W2102234502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2442626" @default.
- W2102234502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18606859" @default.
- W2102234502 hasPublicationYear "2008" @default.
- W2102234502 type Work @default.
- W2102234502 sameAs 2102234502 @default.
- W2102234502 citedByCount "0" @default.
- W2102234502 crossrefType "journal-article" @default.
- W2102234502 hasAuthorship W2102234502A5022415292 @default.
- W2102234502 hasBestOaLocation W21022345021 @default.
- W2102234502 hasConcept C104317684 @default.
- W2102234502 hasConcept C142362112 @default.
- W2102234502 hasConcept C147446459 @default.
- W2102234502 hasConcept C153349607 @default.
- W2102234502 hasConcept C180754005 @default.
- W2102234502 hasConcept C183920142 @default.
- W2102234502 hasConcept C19317047 @default.
- W2102234502 hasConcept C2776090121 @default.
- W2102234502 hasConcept C2778794311 @default.
- W2102234502 hasConcept C54355233 @default.
- W2102234502 hasConcept C86803240 @default.
- W2102234502 hasConcept C8891405 @default.
- W2102234502 hasConceptScore W2102234502C104317684 @default.
- W2102234502 hasConceptScore W2102234502C142362112 @default.
- W2102234502 hasConceptScore W2102234502C147446459 @default.
- W2102234502 hasConceptScore W2102234502C153349607 @default.
- W2102234502 hasConceptScore W2102234502C180754005 @default.
- W2102234502 hasConceptScore W2102234502C183920142 @default.
- W2102234502 hasConceptScore W2102234502C19317047 @default.
- W2102234502 hasConceptScore W2102234502C2776090121 @default.
- W2102234502 hasConceptScore W2102234502C2778794311 @default.
- W2102234502 hasConceptScore W2102234502C54355233 @default.
- W2102234502 hasConceptScore W2102234502C86803240 @default.
- W2102234502 hasConceptScore W2102234502C8891405 @default.
- W2102234502 hasIssue "7" @default.
- W2102234502 hasLocation W21022345021 @default.
- W2102234502 hasLocation W21022345022 @default.
- W2102234502 hasLocation W21022345023 @default.
- W2102234502 hasLocation W21022345024 @default.
- W2102234502 hasOpenAccess W2102234502 @default.
- W2102234502 hasPrimaryLocation W21022345021 @default.
- W2102234502 hasRelatedWork W1915349775 @default.
- W2102234502 hasRelatedWork W2002128513 @default.
- W2102234502 hasRelatedWork W2027281191 @default.
- W2102234502 hasRelatedWork W2057739827 @default.
- W2102234502 hasRelatedWork W2065431377 @default.
- W2102234502 hasRelatedWork W2073263247 @default.
- W2102234502 hasRelatedWork W2107857422 @default.
- W2102234502 hasRelatedWork W2170548043 @default.
- W2102234502 hasRelatedWork W2512831455 @default.
- W2102234502 hasRelatedWork W4255226035 @default.
- W2102234502 hasVolume "205" @default.
- W2102234502 isParatext "false" @default.
- W2102234502 isRetracted "false" @default.
- W2102234502 magId "2102234502" @default.
- W2102234502 workType "article" @default.