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- W2102287029 abstract "To evaluate the effects of low-dose intravitreal injections of bevacizumab (IVB) in retinopathy of prematurity (ROP). A total of 14 eyes of 7 patients received IVB (0.25mg/eye) for treatment of ROP from April 2011 to June 2012 at Showa University. This retrospective case series included the patients who were followed up for at least 5 months after IVB. Ten eyes of five patients were included in the analysis. The mean gestational age and birth weight were 24.6 (range: 22-26) weeks and 770 grams (range: 505-1055), respectively. Eight eyes of four patients with stage 3 ROP with plus disease were laser treated, and two eyes of one patient were treated with aggressive posterior ROP (AP-ROP) without laser use. All of the eyes received only a single injection of IVB. The mean injection age and body weight were 37.2 (range: 34-39) weeks of postconceptional age and 2073 grams (range: 1400-2995). Of the eight eyes with stage 3 ROP with plus disease, six eyes (four patients) regressed after IVB treatment. Two eyes (two patients) were treated with vitrectomy after IVB. The AP-ROP regressed after IVB and a subsequent laser treatment. IVB was performed as a salvage therapy, and low-dose IVB was effective for promoting the regression of ROP. However, IVB increased fibrotic traction in some eyes. In the BEAT-ROP study, a dosage of 0.625mg IVB was used as a monotherapy; however, intravitreally injected bevacizumab can escape to the systemic circulation. Thus, the use of a lower dosage of IVB for ROP in combination with laser therapy appears to be efficacious until the optimal dosage can be established." @default.
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- W2102287029 date "2014-01-01" @default.
- W2102287029 modified "2023-09-28" @default.
- W2102287029 title "Effects of Low Dose of Intravitreal Bevacizumab in Retinopathy of Prematurity" @default.
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- W2102287029 doi "https://doi.org/10.15369/sujms.26.95" @default.
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