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- W2102303758 endingPage "74" @default.
- W2102303758 startingPage "53" @default.
- W2102303758 abstract "Since the original somatomedin hypothesis was conceived, a number of important discoveries have allowed investigators to modify the concept. Originally somatic growth was thought to be controlled by pituitary GH and mediated by circulating insulin-like growth factor-I (IGF-I, somatomedin C) expressed exclusively by the liver. With the discovery that IGF-I is produced by most, if not all, tissues, the role of autocrine/paracrine IGF-I vs. the circulating form has been hotly debated. Recent experiments using transgenic and gene-deletion technologies have attempted to answer these questions. In the liverspecific igf-1 gene-deleted mouse model, postnatal growth and development are normal despite the marked reduction in circulating IGF-I and IGF-binding protein levels; free IGF-I levels are normal. Thus, the normal postnatal growth and development in these animals may be due to normal free IGF-I levels (from as yet unidentified sources), although the role of autocrine/paracrine IGF-I has yet to be determined." @default.
- W2102303758 created "2016-06-24" @default.
- W2102303758 creator A5007898120 @default.
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- W2102303758 creator A5037014030 @default.
- W2102303758 creator A5065361249 @default.
- W2102303758 creator A5078099225 @default.
- W2102303758 date "2001-02-01" @default.
- W2102303758 modified "2023-10-14" @default.
- W2102303758 title "The Somatomedin Hypothesis: 2001" @default.
- W2102303758 cites W122685959 @default.
- W2102303758 cites W1488424161 @default.
- W2102303758 cites W1534439131 @default.
- W2102303758 cites W1534981615 @default.
- W2102303758 cites W1547466369 @default.
- W2102303758 cites W1555931521 @default.
- W2102303758 cites W1564546569 @default.
- W2102303758 cites W1577885145 @default.
- W2102303758 cites W1579739997 @default.
- W2102303758 cites W1585635925 @default.
- W2102303758 cites W1593790770 @default.
- W2102303758 cites W1595565889 @default.
- W2102303758 cites W1606315898 @default.
- W2102303758 cites W176746488 @default.
- W2102303758 cites W1871669466 @default.
- W2102303758 cites W1931051077 @default.
- W2102303758 cites W1931843124 @default.
- W2102303758 cites W1963659433 @default.
- W2102303758 cites W1964614824 @default.
- W2102303758 cites W1964814953 @default.
- W2102303758 cites W1966074006 @default.
- W2102303758 cites W1966507045 @default.
- W2102303758 cites W1968113908 @default.
- W2102303758 cites W1969107116 @default.
- W2102303758 cites W1970285990 @default.
- W2102303758 cites W1972083618 @default.
- W2102303758 cites W1973102414 @default.
- W2102303758 cites W1973307993 @default.
- W2102303758 cites W1974117849 @default.
- W2102303758 cites W1974391793 @default.
- W2102303758 cites W1977340858 @default.
- W2102303758 cites W1978744281 @default.
- W2102303758 cites W1980214906 @default.
- W2102303758 cites W1982134009 @default.
- W2102303758 cites W1983764158 @default.
- W2102303758 cites W1984035921 @default.
- W2102303758 cites W1984357249 @default.
- W2102303758 cites W1986161955 @default.
- W2102303758 cites W1986625462 @default.
- W2102303758 cites W1987346827 @default.
- W2102303758 cites W1989495738 @default.
- W2102303758 cites W1990862055 @default.
- W2102303758 cites W1993776398 @default.
- W2102303758 cites W1995555012 @default.
- W2102303758 cites W1995734405 @default.
- W2102303758 cites W1995945960 @default.
- W2102303758 cites W1998776130 @default.
- W2102303758 cites W1999801514 @default.
- W2102303758 cites W2000279485 @default.
- W2102303758 cites W2000989152 @default.
- W2102303758 cites W2003967740 @default.
- W2102303758 cites W2007217993 @default.
- W2102303758 cites W2007595691 @default.
- W2102303758 cites W2008367574 @default.
- W2102303758 cites W2009229053 @default.
- W2102303758 cites W2010034236 @default.
- W2102303758 cites W2011182863 @default.
- W2102303758 cites W2011264397 @default.
- W2102303758 cites W2011610488 @default.
- W2102303758 cites W2012559101 @default.
- W2102303758 cites W2012898950 @default.
- W2102303758 cites W2013743258 @default.
- W2102303758 cites W2014205262 @default.
- W2102303758 cites W2014493428 @default.
- W2102303758 cites W2015223742 @default.
- W2102303758 cites W2016141014 @default.
- W2102303758 cites W2017578846 @default.
- W2102303758 cites W2017949036 @default.
- W2102303758 cites W2019772246 @default.
- W2102303758 cites W2020221478 @default.
- W2102303758 cites W2021130150 @default.
- W2102303758 cites W2022200688 @default.
- W2102303758 cites W2023892192 @default.
- W2102303758 cites W2024394264 @default.
- W2102303758 cites W2024531944 @default.
- W2102303758 cites W2025724368 @default.
- W2102303758 cites W2026111013 @default.
- W2102303758 cites W2026339736 @default.
- W2102303758 cites W2026436880 @default.
- W2102303758 cites W2029869230 @default.
- W2102303758 cites W2030633235 @default.
- W2102303758 cites W2031132965 @default.
- W2102303758 cites W2031871114 @default.
- W2102303758 cites W2032511791 @default.
- W2102303758 cites W2033449137 @default.
- W2102303758 cites W2034644036 @default.
- W2102303758 cites W2035372169 @default.
- W2102303758 cites W2037724297 @default.