FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102311237> ?p ?o ?g. }

• W2102311237 endingPage "E976" @default.
• W2102311237 startingPage "E964" @default.
• W2102311237 abstract "We generated three fully human monoclonal antibody antagonists against fibroblast growth factor receptor-1 (FGFR1) that potently block FGF signaling. We found that antibodies targeting the c-splice form of the receptor (FGFR1c) were anorexigenic when administered intraperitoneally three times weekly to mice, resulting in rapid, dose-dependent weight loss that plateaued (for doses >4 mg/kg) at 35–40% in 2 wk. Animals appeared healthy during treatment and regained their normal body weights and growth trajectories upon clearance of the antibodies from the bloodstream. Measurements of food consumption and energy expenditure indicated that the rapid weight loss was induced primarily by decreased energy intake and not by increased energy expenditure or cachexia and was accompanied by a greater reduction in fat than lean body mass. Hypophagia was not caused through malaise or illness, as indicated by absence of conditioned taste aversion, pica behavior, and decreased need-induced salt intake in rats. In support of a hypothalamic site of action, we found that, after intraperitoneal injections, anti-FGFR1c (IMC-A1), but not a control antibody, accumulated in the median eminence and adjacent mediobasal hypothalamus and that FGFR1c is enriched in the hypothalamus of mice. Furthermore, a single intracerebroventricular administration of 3 μg of IMC-A1 via the 3rd ventricle to mice caused an ∼36% reduction in food intake and an ∼6% weight loss within the ensuing 24 h. Our data suggest that FGF signaling through FGFR1c may play a physiological role in hypothalamic feeding circuit and that blocking it leads to hypophagia and weight loss." @default.
• W2102311237 created "2016-06-24" @default.
• W2102311237 creator A5005825467 @default.
• W2102311237 creator A5019253691 @default.
• W2102311237 creator A5025336530 @default.
• W2102311237 creator A5026561537 @default.
• W2102311237 creator A5035328820 @default.
• W2102311237 creator A5044213024 @default.
• W2102311237 creator A5049194285 @default.
• W2102311237 creator A5059035410 @default.
• W2102311237 creator A5064026568 @default.
• W2102311237 creator A5075372173 @default.
• W2102311237 creator A5080990622 @default.
• W2102311237 creator A5088352176 @default.
• W2102311237 date "2007-03-01" @default.
• W2102311237 modified "2023-10-18" @default.
• W2102311237 title "Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys" @default.
• W2102311237 cites W1208024610 @default.
• W2102311237 cites W1513451331 @default.
• W2102311237 cites W1556108117 @default.
• W2102311237 cites W1966681272 @default.
• W2102311237 cites W1967734976 @default.
• W2102311237 cites W1978925512 @default.
• W2102311237 cites W1982098988 @default.
• W2102311237 cites W1983104536 @default.
• W2102311237 cites W1992392163 @default.
• W2102311237 cites W1999411121 @default.
• W2102311237 cites W2000665430 @default.
• W2102311237 cites W2001990792 @default.
• W2102311237 cites W2003905949 @default.
• W2102311237 cites W2005943019 @default.
• W2102311237 cites W2006659499 @default.
• W2102311237 cites W2007161557 @default.
• W2102311237 cites W2010066949 @default.
• W2102311237 cites W2011817955 @default.
• W2102311237 cites W2015669496 @default.
• W2102311237 cites W2018895555 @default.
• W2102311237 cites W2021253220 @default.
• W2102311237 cites W2022846452 @default.
• W2102311237 cites W2029935185 @default.
• W2102311237 cites W2032161027 @default.
• W2102311237 cites W2035921480 @default.
• W2102311237 cites W2042055907 @default.
• W2102311237 cites W2048474990 @default.
• W2102311237 cites W2051170594 @default.
• W2102311237 cites W2055870797 @default.
• W2102311237 cites W2058586676 @default.
• W2102311237 cites W2063374571 @default.
• W2102311237 cites W2068534669 @default.
• W2102311237 cites W2077425635 @default.
• W2102311237 cites W2080741435 @default.
• W2102311237 cites W2083250868 @default.
• W2102311237 cites W2087037494 @default.
• W2102311237 cites W2087651921 @default.
• W2102311237 cites W2098489373 @default.
• W2102311237 cites W2106086622 @default.
• W2102311237 cites W2106986971 @default.
• W2102311237 cites W2107551481 @default.
• W2102311237 cites W2109742508 @default.
• W2102311237 cites W2122892477 @default.
• W2102311237 cites W2131650129 @default.
• W2102311237 cites W2138178479 @default.
• W2102311237 cites W2143917529 @default.
• W2102311237 cites W2154217448 @default.
• W2102311237 cites W2156744437 @default.
• W2102311237 cites W2164331820 @default.
• W2102311237 cites W2169403756 @default.
• W2102311237 cites W2183545514 @default.
• W2102311237 cites W2266896860 @default.
• W2102311237 cites W2279195924 @default.
• W2102311237 cites W2341830035 @default.
• W2102311237 cites W2440028469 @default.
• W2102311237 cites W4231924994 @default.
• W2102311237 cites W4242631323 @default.
• W2102311237 cites W4252537293 @default.
• W2102311237 doi "https://doi.org/10.1152/ajpendo.00089.2006" @default.
• W2102311237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17132826" @default.
• W2102311237 hasPublicationYear "2007" @default.
• W2102311237 type Work @default.
• W2102311237 sameAs 2102311237 @default.
• W2102311237 citedByCount "83" @default.
• W2102311237 countsByYear W21023112372012 @default.
• W2102311237 countsByYear W21023112372013 @default.
• W2102311237 countsByYear W21023112372014 @default.
• W2102311237 countsByYear W21023112372015 @default.
• W2102311237 countsByYear W21023112372016 @default.
• W2102311237 countsByYear W21023112372017 @default.
• W2102311237 countsByYear W21023112372018 @default.
• W2102311237 countsByYear W21023112372019 @default.
• W2102311237 countsByYear W21023112372020 @default.
• W2102311237 countsByYear W21023112372021 @default.
• W2102311237 countsByYear W21023112372022 @default.
• W2102311237 countsByYear W21023112372023 @default.
• W2102311237 crossrefType "journal-article" @default.
• W2102311237 hasAuthorship W2102311237A5005825467 @default.
• W2102311237 hasAuthorship W2102311237A5019253691 @default.
• W2102311237 hasAuthorship W2102311237A5025336530 @default.
• W2102311237 hasAuthorship W2102311237A5026561537 @default.

• next