FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102327720> ?p ?o ?g. }

• W2102327720 endingPage "116" @default.
• W2102327720 startingPage "111" @default.
• W2102327720 abstract "Inositol pyrophosphates (such as IP7 and IP8) are multifunctional signaling molecules that regulate diverse cellular activities. Inositol pyrophosphates have 'high-energy' phosphoanhydride bonds, so their enzymatic synthesis requires that a substantial energy barrier to the transition state be overcome. Additionally, inositol pyrophosphate kinases can show stringent ligand specificity, despite the need to accommodate the steric bulk and intense electronegativity of nature's most concentrated three-dimensional array of phosphate groups. Here we examine how these catalytic challenges are met by describing the structure and reaction cycle of an inositol pyrophosphate kinase at the atomic level. We obtained crystal structures of the kinase domain of human PPIP5K2 complexed with nucleotide cofactors and either substrates, product or a MgF(3)(-) transition-state mimic. We describe the enzyme's conformational dynamics, its unprecedented topological presentation of nucleotide and inositol phosphate, and the charge balance that facilitates partly associative in-line phosphoryl transfer." @default.
• W2102327720 created "2016-06-24" @default.
• W2102327720 creator A5013107971 @default.
• W2102327720 creator A5014823244 @default.
• W2102327720 creator A5045321370 @default.
• W2102327720 creator A5077198825 @default.
• W2102327720 date "2011-11-27" @default.
• W2102327720 modified "2023-10-16" @default.
• W2102327720 title "Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding" @default.
• W2102327720 cites W1485488844 @default.
• W2102327720 cites W1506664007 @default.
• W2102327720 cites W1507232548 @default.
• W2102327720 cites W1539796472 @default.
• W2102327720 cites W1600022110 @default.
• W2102327720 cites W1888156959 @default.
• W2102327720 cites W1964365069 @default.
• W2102327720 cites W1970513264 @default.
• W2102327720 cites W1977794494 @default.
• W2102327720 cites W1979928517 @default.
• W2102327720 cites W1993749254 @default.
• W2102327720 cites W2002366878 @default.
• W2102327720 cites W2008245136 @default.
• W2102327720 cites W2009503877 @default.
• W2102327720 cites W2016391867 @default.
• W2102327720 cites W2022517367 @default.
• W2102327720 cites W2023065755 @default.
• W2102327720 cites W2024388103 @default.
• W2102327720 cites W2028017072 @default.
• W2102327720 cites W2030517878 @default.
• W2102327720 cites W2031755602 @default.
• W2102327720 cites W2033574285 @default.
• W2102327720 cites W2038351234 @default.
• W2102327720 cites W2043427242 @default.
• W2102327720 cites W2046122733 @default.
• W2102327720 cites W2048947602 @default.
• W2102327720 cites W2050103345 @default.
• W2102327720 cites W2059141024 @default.
• W2102327720 cites W2067082658 @default.
• W2102327720 cites W2069031972 @default.
• W2102327720 cites W2076809971 @default.
• W2102327720 cites W2080052604 @default.
• W2102327720 cites W2092401154 @default.
• W2102327720 cites W2098940989 @default.
• W2102327720 cites W2126788666 @default.
• W2102327720 cites W2136447771 @default.
• W2102327720 cites W2144081223 @default.
• W2102327720 cites W2149781029 @default.
• W2102327720 cites W2180229411 @default.
• W2102327720 cites W4302777425 @default.
• W2102327720 doi "https://doi.org/10.1038/nchembio.733" @default.
• W2102327720 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3923263" @default.
• W2102327720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22119861" @default.
• W2102327720 hasPublicationYear "2011" @default.
• W2102327720 type Work @default.
• W2102327720 sameAs 2102327720 @default.
• W2102327720 citedByCount "110" @default.
• W2102327720 countsByYear W21023277202012 @default.
• W2102327720 countsByYear W21023277202013 @default.
• W2102327720 countsByYear W21023277202014 @default.
• W2102327720 countsByYear W21023277202015 @default.
• W2102327720 countsByYear W21023277202016 @default.
• W2102327720 countsByYear W21023277202017 @default.
• W2102327720 countsByYear W21023277202018 @default.
• W2102327720 countsByYear W21023277202019 @default.
• W2102327720 countsByYear W21023277202020 @default.
• W2102327720 countsByYear W21023277202021 @default.
• W2102327720 countsByYear W21023277202022 @default.
• W2102327720 countsByYear W21023277202023 @default.
• W2102327720 crossrefType "journal-article" @default.
• W2102327720 hasAuthorship W2102327720A5013107971 @default.
• W2102327720 hasAuthorship W2102327720A5014823244 @default.
• W2102327720 hasAuthorship W2102327720A5045321370 @default.
• W2102327720 hasAuthorship W2102327720A5077198825 @default.
• W2102327720 hasBestOaLocation W21023277202 @default.
• W2102327720 hasConcept C170493617 @default.
• W2102327720 hasConcept C181199279 @default.
• W2102327720 hasConcept C184235292 @default.
• W2102327720 hasConcept C185592680 @default.
• W2102327720 hasConcept C2776043855 @default.
• W2102327720 hasConcept C2777427919 @default.
• W2102327720 hasConcept C2778618036 @default.
• W2102327720 hasConcept C55493867 @default.
• W2102327720 hasConceptScore W2102327720C170493617 @default.
• W2102327720 hasConceptScore W2102327720C181199279 @default.
• W2102327720 hasConceptScore W2102327720C184235292 @default.
• W2102327720 hasConceptScore W2102327720C185592680 @default.
• W2102327720 hasConceptScore W2102327720C2776043855 @default.
• W2102327720 hasConceptScore W2102327720C2777427919 @default.
• W2102327720 hasConceptScore W2102327720C2778618036 @default.
• W2102327720 hasConceptScore W2102327720C55493867 @default.
• W2102327720 hasIssue "1" @default.
• W2102327720 hasLocation W21023277201 @default.
• W2102327720 hasLocation W21023277202 @default.
• W2102327720 hasLocation W21023277203 @default.
• W2102327720 hasLocation W21023277204 @default.
• W2102327720 hasOpenAccess W2102327720 @default.
• W2102327720 hasPrimaryLocation W21023277201 @default.
• W2102327720 hasRelatedWork W2002372710 @default.

• next