Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102330235> ?p ?o ?g. }
- W2102330235 endingPage "e5661" @default.
- W2102330235 startingPage "e5661" @default.
- W2102330235 abstract "<h3>Abstract</h3> In age-related neurodegenerative disease, like Alzheimer’s and Parkinson’s disease, disease-specific proteins become aggregation-prone and form amyloid-like deposits. Depletion of SERF proteins ameliorates this toxic process in worm- and human cell models for disease. Whether SERF modifies amyloid pathology in mammalian brain, however, has remained unknown. Here, we generated SERF2 brain-specific knockout mice which, unlike full body knockout mice, were viable, and showed no major behavioral and cognitive abnormalities. We combined these knockout mice with the APPPS1 mouse model for human amyloid beta aggregation. Using structure-specific amyloid dyes, previously used to distinguish amyloid polymorphisms in human brain, we show that knockout of SERF2 alters the structure of amyloid fibrils and deposits. Moreover, scanning transmission electron microscopy revealed thicker, shorter and more densely packed amyloid in absence of SERF2. Altogether, our data reveal pleiotropic functions of SERF in development and aging and support a function as a modifier of amyloid aggregation in mammalian brain. Our results indicate that single cellular factors like SERF can determine the structural outcome of amyloid aggregation, offering possibilities for polymorphism-based disease interventions." @default.
- W2102330235 created "2016-06-24" @default.
- W2102330235 creator A5029460720 @default.
- W2102330235 creator A5042962646 @default.
- W2102330235 creator A5057505939 @default.
- W2102330235 creator A5085130210 @default.
- W2102330235 date "2012-09-04" @default.
- W2102330235 modified "2023-10-11" @default.
- W2102330235 title "Consort 2010 statement: extension to cluster randomised trials" @default.
- W2102330235 cites W143864954 @default.
- W2102330235 cites W1501619595 @default.
- W2102330235 cites W1558547099 @default.
- W2102330235 cites W1587990062 @default.
- W2102330235 cites W170006779 @default.
- W2102330235 cites W1791960638 @default.
- W2102330235 cites W1975752937 @default.
- W2102330235 cites W1976688779 @default.
- W2102330235 cites W1978318333 @default.
- W2102330235 cites W1980043956 @default.
- W2102330235 cites W1983146304 @default.
- W2102330235 cites W1986360186 @default.
- W2102330235 cites W1987232265 @default.
- W2102330235 cites W1988769265 @default.
- W2102330235 cites W1992890846 @default.
- W2102330235 cites W1993690981 @default.
- W2102330235 cites W1996063904 @default.
- W2102330235 cites W1999218614 @default.
- W2102330235 cites W2011932878 @default.
- W2102330235 cites W2012958050 @default.
- W2102330235 cites W2020316895 @default.
- W2102330235 cites W2021764662 @default.
- W2102330235 cites W202411737 @default.
- W2102330235 cites W2025833127 @default.
- W2102330235 cites W2032062976 @default.
- W2102330235 cites W2033890227 @default.
- W2102330235 cites W2038618446 @default.
- W2102330235 cites W2043512940 @default.
- W2102330235 cites W2046617780 @default.
- W2102330235 cites W2049321668 @default.
- W2102330235 cites W2057320251 @default.
- W2102330235 cites W2058874144 @default.
- W2102330235 cites W2061048644 @default.
- W2102330235 cites W2065183593 @default.
- W2102330235 cites W2067997434 @default.
- W2102330235 cites W2072070392 @default.
- W2102330235 cites W2078780468 @default.
- W2102330235 cites W2082066334 @default.
- W2102330235 cites W2083081439 @default.
- W2102330235 cites W2084639013 @default.
- W2102330235 cites W2085005241 @default.
- W2102330235 cites W2087698342 @default.
- W2102330235 cites W2091752011 @default.
- W2102330235 cites W2093029291 @default.
- W2102330235 cites W2097112083 @default.
- W2102330235 cites W2102794164 @default.
- W2102330235 cites W2106202364 @default.
- W2102330235 cites W2107091967 @default.
- W2102330235 cites W2107879495 @default.
- W2102330235 cites W2109866440 @default.
- W2102330235 cites W2110676524 @default.
- W2102330235 cites W2111240292 @default.
- W2102330235 cites W2117997750 @default.
- W2102330235 cites W2118804618 @default.
- W2102330235 cites W2121944882 @default.
- W2102330235 cites W2124794946 @default.
- W2102330235 cites W2127719902 @default.
- W2102330235 cites W2134144126 @default.
- W2102330235 cites W2139030977 @default.
- W2102330235 cites W2140105270 @default.
- W2102330235 cites W2142960568 @default.
- W2102330235 cites W2144504916 @default.
- W2102330235 cites W2146588385 @default.
- W2102330235 cites W2146745032 @default.
- W2102330235 cites W2147119554 @default.
- W2102330235 cites W2147581820 @default.
- W2102330235 cites W2156079350 @default.
- W2102330235 cites W2164947695 @default.
- W2102330235 cites W2166755875 @default.
- W2102330235 cites W2169168582 @default.
- W2102330235 cites W2171505089 @default.
- W2102330235 cites W2185543853 @default.
- W2102330235 cites W2197909299 @default.
- W2102330235 cites W2726799618 @default.
- W2102330235 cites W2121626229 @default.
- W2102330235 doi "https://doi.org/10.1136/bmj.e5661" @default.
- W2102330235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/381234" @default.
- W2102330235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22951546" @default.
- W2102330235 hasPublicationYear "2012" @default.
- W2102330235 type Work @default.
- W2102330235 sameAs 2102330235 @default.
- W2102330235 citedByCount "1886" @default.
- W2102330235 countsByYear W21023302352012 @default.
- W2102330235 countsByYear W21023302352013 @default.
- W2102330235 countsByYear W21023302352014 @default.
- W2102330235 countsByYear W21023302352015 @default.
- W2102330235 countsByYear W21023302352016 @default.
- W2102330235 countsByYear W21023302352017 @default.
- W2102330235 countsByYear W21023302352018 @default.