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• W2102331745 startingPage "1645" @default.
• W2102331745 abstract "The purpose of this study was to determine the effect of heparin-binding epidermal growth factor (HB-EGF) on human embryo development in vitro from days 2 to 14 post-insemination. Embryos were cultured in a complex serum-free medium (CSFM3) in the absence and presence of 1 nM and 100 nM HB-EGF. Development to the blastocyst stage of A-C-grade embryos (A grade = highest quality) was improved in the presence of 1 nM HB-EGF from 40.7% to 65.4% and significantly increased to 71.0% in the presence of 100 nM HB-EGF (P < 0.05). Moreover, the percentage of blastocysts hatching was improved in the presence of 1 nM HB-EGF from 45.5% to 70.5% and almost doubled to 81.8% (P < 0.05) in the presence of 100 nM HB-EGF. HB-EGF promoted the development of high-grade (classed as BG1) and medium-grade (BG2) blastocysts. There was no difference in blastocyst quality between the control and HB-EGF-treated embryos as assessed by blastocyst cell number and consumption of the major energy substrates, pyruvate and glucose, measured on day 6 of culture. Further development was assessed by culturing the blastocysts on growth factor-reduced Matrigel (GFR-Matrigel). Adherence and outgrowth were observed, with these embryos producing significantly more human chorionic gonadotrophin over days 7-14 compared with those cultured on plastic (47.8 +/- 8.0 mU versus 23.0 +/- 8.6 mU). The addition of recombinant human growth factors to clinical in-vitro fertilization medium may be useful in promoting embryo development with a view to carrying out blastocyst transfers." @default.
• W2102331745 created "2016-06-24" @default.
• W2102331745 creator A5001296794 @default.
• W2102331745 creator A5019167533 @default.
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• W2102331745 date "1998-06-01" @default.
• W2102331745 modified "2023-10-01" @default.
• W2102331745 title "Heparin-binding epidermal growth factor significantly improves human blastocyst development and hatching in serum-free medium" @default.
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• W2102331745 doi "https://doi.org/10.1093/humrep/13.6.1645" @default.
• W2102331745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9688406" @default.
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