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- W2102332334 abstract "Murry et al.,14 were the first to demonstrate the phenomenon of preconditioning of a tissue against ischemic injury. In dogs, a series of short coronary artery occlusions, followed by reperfusion, protected the heart from a subsequent lethal ischemia and reperfusion. This phenomenon was shown to be initiated by the binding of adenosine, the ischemia-induced degradation product of ATP, to the A1 receptor on the cell outer membrane, activating a signal transduction pathway, resulting finally in improved ability to resist the ischemic damage.13 The ‘adenosine mechanism’ in the heart tissue was found to be characterized by a relatively short ‘time window of protection’, appearing immediately but extending for only 60–120 min.1,14 Very recently, however, a delayed ‘second time window of protection’ was reported in the heart model, appearing and lasting days after the induction of preconditioning.9,12,19" @default.
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- W2102332334 date "1998-01-01" @default.
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- W2102332334 title "Adenosine-Induced Preconditioning of Rat Neuronal Cultures Against Ischemia-Reperfusion Injury" @default.
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- W2102332334 doi "https://doi.org/10.1007/978-1-4615-5381-6_72" @default.
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