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• W2102340949 startingPage "874" @default.
• W2102340949 abstract "HIV-1 associated dementia is thought to be caused by neuronal damage and death in response to the production of soluble neurotoxic factors by virally infected mononuclear phagocytes. These neurotoxins include HIV-1 Tat. The ability of neurotrophins to promote cell survival prompted us to examine whether neurotrophins might also be capable of opposing the pro-apoptotic effects of Tat. Here, we show that Tat-induced neuronal apoptosis in primary cultures of rat cerebellar granule cells and in neuronally differentiated human SK-N-MC cells is profoundly inhibited by brain-derived neurotrophic factor, nerve growth factor and activity-dependent neurotrophic factor nonamer peptide. These neurotrophins activated the transcription factor NF-κB, and inhibition of NF-κB activation using a super-repressor IκB-α mutant was found to block the survival-promoting activity of the neurotrophins. Reporter gene assays and immunoblot experiments revealed that the neurotrophins also up-regulated the expression of Bcl-2, at both the transcriptional and protein levels. Overexpression of the super-repressor IκB-α mutant prevented this induction of Bcl-2 expression. Moreover, overexpression of either Bcl-2, alone, or the RelA subunit of NF-κB, alone, protected neurons from Tat-induced apoptosis. These findings suggest that the activation of NF-κB by neurotrophic factors may promote survival of neurons exposed to Tat, via regulation of anti-apoptotic genes including Bcl-2." @default.
• W2102340949 created "2016-06-24" @default.
• W2102340949 creator A5033658367 @default.
• W2102340949 creator A5033967453 @default.
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• W2102340949 creator A5054468518 @default.
• W2102340949 creator A5073227816 @default.
• W2102340949 creator A5076244533 @default.
• W2102340949 date "2001-12-20" @default.
• W2102340949 modified "2023-10-13" @default.
• W2102340949 title "Neurotrophins prevent HIV Tat-induced neuronal apoptosis via a nuclear factor-κB (NF-κB)-dependent mechanism" @default.
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• W2102340949 doi "https://doi.org/10.1046/j.1471-4159.2001.00467.x" @default.
• W2102340949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11520908" @default.
• W2102340949 hasPublicationYear "2001" @default.
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