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• W2102366186 abstract "The purpose of this study is to investigate the relationship between corticosteroid use and central serous chorioretinopathy (CSC).A prospective, case-controlled study.A consecutive series of patients with acute manifestations of CSC and a control group matched for age, race, and gender were recruited between January 2000 and July 2000.A detailed clinical history was taken, and fundus examination with slit-lamp biomicroscopy was performed on all patients. Fluorescein angiography was obtained on the study patients.A total of 50 patients was recruited. Twenty-six patients (52%) had a history of exogenous steroid use, including oral, intravenous, intranasal, and intraarticular administration. Two additional patients had a history of endogenous hypercortisolism (Cushing's syndrome). In a matched control group, eight patients (18%) had a history of steroid use. The difference in corticosteroid exposure between study patients and controls was statistically significant (P < 0.0001).History of corticosteroid use or Cushing's syndrome.This study is consistent with previous reports associating steroid use with CSC. It identifies corticosteroids as a significant risk factor for the development of acute, exudative macular manifestation and implicates hypercortisolism as a factor in the pathogenesis of this disorder. Several forms of corticosteroid administration were observed to be a risk factor for CSC. Accordingly, susceptible patients in need of corticosteroids should be advised of the risk of developing acute manifestations of CSC." @default.
• W2102366186 created "2016-06-24" @default.
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• W2102366186 date "2002-10-01" @default.
• W2102366186 modified "2023-09-30" @default.
• W2102366186 title "Corticosteroids and central serous chorioretinopathy" @default.
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• W2102366186 doi "https://doi.org/10.1016/s0161-6420(02)01117-x" @default.
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