FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102381549> ?p ?o ?g. }

• W2102381549 endingPage "579" @default.
• W2102381549 startingPage "570" @default.
• W2102381549 abstract "In human glioma, quantitative real-time reverse-transcription PCR (qPCR) is a frequently used research tool. However, no systematic analysis of suitable reference genes for reliable gene expression analysis has been performed so far. In the current study, we tested 19 commonly used reference genes for their expression stability in human astrocytoma WHO Grade II, astrocytoma WHO Grade III, and glioblastoma (WHO Grade IV) both alone and compared with normal brain. First, equivalence tests for equal expression of candidate genes were applied, and those genes showing differential expression were ruled out from further analyses. Second, expression stability of the remaining candidate genes was determined by the NormFinder software. Generally, glioblastoma exhibited the highest expression levels and largest variability of candidate genes, whereas the opposite was true for normal brain. Even though Normfinder analyses revealed a large number of genes suitable for normalization in each of the tumor subgroups and across these groups, this number was drastically reduced after inclusion of normal brain into the analyses: Only GAPDH, IPO8, RPL13A, SDHA, and TBP were expected not to be differentially expressed; NormFinder analysis indicated favorable stability values for all of these genes, with TBP and IPO8 being the most stable ones. These 5 genes represent different physiological pathways and may be regarded as universal reference genes applicable for accurate normalization of gene expression in human astrocytomas of different grades (WHO Grades II-IV) alone and compared with normal brain, thereby enabling longitudinally designed studies (eg, in astrocytoma before and after malignant transformation)." @default.
• W2102381549 created "2016-06-24" @default.
• W2102381549 creator A5009911709 @default.
• W2102381549 creator A5013673014 @default.
• W2102381549 creator A5049075068 @default.
• W2102381549 creator A5050502610 @default.
• W2102381549 creator A5056727422 @default.
• W2102381549 creator A5062781311 @default.
• W2102381549 date "2010-02-05" @default.
• W2102381549 modified "2023-10-16" @default.
• W2102381549 title "Identification of valid endogenous control genes for determining gene expression in human glioma" @default.
• W2102381549 cites W130854627 @default.
• W2102381549 cites W1550838463 @default.
• W2102381549 cites W1604703931 @default.
• W2102381549 cites W1965583321 @default.
• W2102381549 cites W1979975126 @default.
• W2102381549 cites W1982706153 @default.
• W2102381549 cites W2001582636 @default.
• W2102381549 cites W2008183439 @default.
• W2102381549 cites W2009467250 @default.
• W2102381549 cites W2029170971 @default.
• W2102381549 cites W2034223072 @default.
• W2102381549 cites W2036044314 @default.
• W2102381549 cites W2053754324 @default.
• W2102381549 cites W2053994623 @default.
• W2102381549 cites W2057464020 @default.
• W2102381549 cites W2069091539 @default.
• W2102381549 cites W2077179648 @default.
• W2102381549 cites W2105423509 @default.
• W2102381549 cites W2108244474 @default.
• W2102381549 cites W2114570899 @default.
• W2102381549 cites W2117483311 @default.
• W2102381549 cites W2121777852 @default.
• W2102381549 cites W2122749842 @default.
• W2102381549 cites W2123845663 @default.
• W2102381549 cites W2125369737 @default.
• W2102381549 cites W2127535576 @default.
• W2102381549 cites W2146803439 @default.
• W2102381549 cites W2149548143 @default.
• W2102381549 cites W2149783560 @default.
• W2102381549 cites W2151853926 @default.
• W2102381549 cites W2154127252 @default.
• W2102381549 cites W2164095252 @default.
• W2102381549 cites W2166847050 @default.
• W2102381549 cites W2170164677 @default.
• W2102381549 doi "https://doi.org/10.1093/neuonc/nop072" @default.
• W2102381549 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2940642" @default.
• W2102381549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20511187" @default.
• W2102381549 hasPublicationYear "2010" @default.
• W2102381549 type Work @default.
• W2102381549 sameAs 2102381549 @default.
• W2102381549 citedByCount "52" @default.
• W2102381549 countsByYear W21023815492012 @default.
• W2102381549 countsByYear W21023815492013 @default.
• W2102381549 countsByYear W21023815492014 @default.
• W2102381549 countsByYear W21023815492015 @default.
• W2102381549 countsByYear W21023815492016 @default.
• W2102381549 countsByYear W21023815492017 @default.
• W2102381549 countsByYear W21023815492018 @default.
• W2102381549 countsByYear W21023815492019 @default.
• W2102381549 countsByYear W21023815492020 @default.
• W2102381549 countsByYear W21023815492021 @default.
• W2102381549 countsByYear W21023815492022 @default.
• W2102381549 countsByYear W21023815492023 @default.
• W2102381549 crossrefType "journal-article" @default.
• W2102381549 hasAuthorship W2102381549A5009911709 @default.
• W2102381549 hasAuthorship W2102381549A5013673014 @default.
• W2102381549 hasAuthorship W2102381549A5049075068 @default.
• W2102381549 hasAuthorship W2102381549A5050502610 @default.
• W2102381549 hasAuthorship W2102381549A5056727422 @default.
• W2102381549 hasAuthorship W2102381549A5062781311 @default.
• W2102381549 hasBestOaLocation W21023815491 @default.
• W2102381549 hasConcept C104317684 @default.
• W2102381549 hasConcept C150194340 @default.
• W2102381549 hasConcept C18431079 @default.
• W2102381549 hasConcept C2778227246 @default.
• W2102381549 hasConcept C2778880634 @default.
• W2102381549 hasConcept C2779148672 @default.
• W2102381549 hasConcept C33922130 @default.
• W2102381549 hasConcept C54355233 @default.
• W2102381549 hasConcept C69991583 @default.
• W2102381549 hasConcept C70721500 @default.
• W2102381549 hasConcept C86803240 @default.
• W2102381549 hasConceptScore W2102381549C104317684 @default.
• W2102381549 hasConceptScore W2102381549C150194340 @default.
• W2102381549 hasConceptScore W2102381549C18431079 @default.
• W2102381549 hasConceptScore W2102381549C2778227246 @default.
• W2102381549 hasConceptScore W2102381549C2778880634 @default.
• W2102381549 hasConceptScore W2102381549C2779148672 @default.
• W2102381549 hasConceptScore W2102381549C33922130 @default.
• W2102381549 hasConceptScore W2102381549C54355233 @default.
• W2102381549 hasConceptScore W2102381549C69991583 @default.
• W2102381549 hasConceptScore W2102381549C70721500 @default.
• W2102381549 hasConceptScore W2102381549C86803240 @default.
• W2102381549 hasIssue "6" @default.
• W2102381549 hasLocation W21023815491 @default.
• W2102381549 hasLocation W21023815492 @default.
• W2102381549 hasLocation W21023815493 @default.

• next