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• W2102385097 abstract "In shrimp, small GTPases in the Ras superfamily can regulate hemolytic phagocytosis against WSSV infection. However, the ADP ribosylation factors (Arfs), also belonging to the regulatory GTP-binding proteins and playing a central role in membrane trafficking, have not been reported yet in shrimp and their relationship with WSSV infection is completely unknown to date. Here, a novel class II Arf (designated as MjArf4) was cloned and characterized from the shrimp Marsupenaeus japonicus. Like other Arfs, MjArf4 contains an N-terminal myristoylated site, a p loop, switch regions, as well as an interswitch region. In High Five cells, when MjArf4 was in its GDP-bound form, it dispersed into the whole cell, whereas in the GTP-bound form it promoted formation of a punctuate Golgi-like structure, indicating that the MjArf4 distribution was dependent on its GDP/GTP binding. After challenge with WSSV, the mRNA level of MjArf4 was up-regulated significantly as WSSV propagated. Thus, a member of the Arf family was characterized for the first time in shrimp and found to be involved in WSSV infection." @default.
• W2102385097 created "2016-06-24" @default.
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• W2102385097 date "2010-01-01" @default.
• W2102385097 modified "2023-09-27" @default.
• W2102385097 title "Molecular cloning and characterization of a class II ADP ribosylation factor from the shrimp Marsupenaeus japonicus" @default.
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• W2102385097 doi "https://doi.org/10.1016/j.fsi.2009.10.008" @default.
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