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• W2102425172 abstract "From mammals to insects, metal-responsive transcription factor 1 (MTF-1) is essential for the activation of metallothionein genes upon heavy-metal load. We have previously found that human MTF-1 induces a stronger metal response than mouse MTF-1. The latter differs from the human one in a number of amino acid positions and is also shorter by 78 aa at its C-terminus. We reasoned that the weaker metal inducibility might be associated with a lesser demand for tight metal homeostasis in a low-weight, short-lived animal, and thus set out to determine the sequence of MTF-1 from the largest living rodent, the Brazilian capybara that can reach 65 kg and also has a considerably longer life span than smaller rodents. An expression clone for capybara MTF-1 was then tested for its activity in both mouse and human cells. Our analysis revealed three unexpected features: i) capybara MTF-1 in terms of amino acid sequence is much more closely related to human than to mouse MTF-1, suggesting an accelerated evolution of MTF-1 in the evolutionary branch leading to small rodents; ii) capybara MTF-1 is even 32 aa shorter at its C-terminus than mouse MTF-1, and iii) in an activity test, it is not more active than mouse MTF-1. The latter two findings might indicate that capybara has evolved in an environment with low heavy-metal load." @default.
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• W2102425172 date "2008-08-01" @default.
• W2102425172 modified "2023-10-16" @default.
• W2102425172 title "Characterization of Metal‐Responsive Transcription Factor (MTF‐1) from the Giant Rodent Capybara Reveals Features in Common with Human as Well as with Small Rodents (Mouse, Rat). Short Communication" @default.
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• W2102425172 doi "https://doi.org/10.1002/cbdv.200890137" @default.
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