FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102425178> ?p ?o ?g. }

• W2102425178 endingPage "307" @default.
• W2102425178 startingPage "303" @default.
• W2102425178 abstract "<h3>Background</h3> The macrolide antibiotics clarithromycin and erythromycin may potentiate calcium-channel blockers by inhibiting cytochrome P450 isoenzyme 3A4. However, this potential drug interaction is widely underappreciated and its clinical consequences have not been well characterized. We explored the risk of hypotension or shock requiring hospital admission following the simultaneous use of calcium-channel blockers and macrolide antibiotics. <h3>Methods</h3> We conducted a population-based, nested, case-crossover study involving people aged 66 years and older who had been prescribed a calcium-channel blocker between Apr. 1, 1994, and Mar. 31, 2009. Of these patients, we included those who had been admitted to hospital for the treatment of hypotension or shock. For each antibiotic, we estimated the risk of hypotension or shock associated with the use of a calcium blocker using a pair-matched analytic approach to contrast each patient’s exposure to each macrolide antibiotic (erythromycin, clarithromycin or azithromycin) in a seven-day risk interval immediately before admission to hospital and in a seven-day control interval one month earlier. <h3>Results</h3> Of the 7100 patients admitted to hospital because of hypotension while receiving a calcium-channel blocker, 176 had been prescribed a macrolide antibiotic during either the risk or control intervals. Erythromycin (the strongest inhibitor of cytochrome P450 3A4) was most strongly associated with hypotension (odds ratio [OR] 5.8, 95% confidence interval [CI] 2.3–15.0), followed by clarithromycin (OR 3.7, 95% CI 2.3–6.1). Azithromycin, which does not inhibit cytochrome P450 3A4, was not associated with an increased risk of hypotension (OR 1.5, 95% CI 0.8–2.8). We found similar results in a stratified analysis of patients who received only dihydropyridine calcium-channel blockers. <h3>Interpretation</h3> In older patients receiving a calcium-channel blocker, use of erythromycin or clarithromycin was associated with an increased risk of hypotension or shock requiring admission to hospital. Preferential use of azithromycin should be considered when a macrolide antibiotic is required for patients already receiving a calcium-channel blocker." @default.
• W2102425178 created "2016-06-24" @default.
• W2102425178 creator A5023024177 @default.
• W2102425178 creator A5049307189 @default.
• W2102425178 creator A5053276850 @default.
• W2102425178 creator A5065468510 @default.
• W2102425178 creator A5072226972 @default.
• W2102425178 date "2011-01-17" @default.
• W2102425178 modified "2023-10-11" @default.
• W2102425178 title "The risk of hypotension following co-prescription of macrolide antibiotics and calcium-channel blockers" @default.
• W2102425178 cites W1531474084 @default.
• W2102425178 cites W1911592487 @default.
• W2102425178 cites W1980446817 @default.
• W2102425178 cites W1981114953 @default.
• W2102425178 cites W1981328065 @default.
• W2102425178 cites W1990652438 @default.
• W2102425178 cites W2005328285 @default.
• W2102425178 cites W2061075125 @default.
• W2102425178 cites W2062975680 @default.
• W2102425178 cites W2088949336 @default.
• W2102425178 cites W2102424421 @default.
• W2102425178 cites W2103481781 @default.
• W2102425178 cites W2111945961 @default.
• W2102425178 cites W2121629456 @default.
• W2102425178 cites W2136527705 @default.
• W2102425178 cites W2138610953 @default.
• W2102425178 cites W2153267334 @default.
• W2102425178 cites W2168374995 @default.
• W2102425178 cites W2282622959 @default.
• W2102425178 cites W2347121788 @default.
• W2102425178 doi "https://doi.org/10.1503/cmaj.100702" @default.
• W2102425178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3042440" @default.
• W2102425178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21242274" @default.
• W2102425178 hasPublicationYear "2011" @default.
• W2102425178 type Work @default.
• W2102425178 sameAs 2102425178 @default.
• W2102425178 citedByCount "74" @default.
• W2102425178 countsByYear W21024251782012 @default.
• W2102425178 countsByYear W21024251782013 @default.
• W2102425178 countsByYear W21024251782014 @default.
• W2102425178 countsByYear W21024251782015 @default.
• W2102425178 countsByYear W21024251782016 @default.
• W2102425178 countsByYear W21024251782017 @default.
• W2102425178 countsByYear W21024251782018 @default.
• W2102425178 countsByYear W21024251782019 @default.
• W2102425178 countsByYear W21024251782020 @default.
• W2102425178 countsByYear W21024251782021 @default.
• W2102425178 countsByYear W21024251782022 @default.
• W2102425178 countsByYear W21024251782023 @default.
• W2102425178 crossrefType "journal-article" @default.
• W2102425178 hasAuthorship W2102425178A5023024177 @default.
• W2102425178 hasAuthorship W2102425178A5049307189 @default.
• W2102425178 hasAuthorship W2102425178A5053276850 @default.
• W2102425178 hasAuthorship W2102425178A5065468510 @default.
• W2102425178 hasAuthorship W2102425178A5072226972 @default.
• W2102425178 hasBestOaLocation W21024251781 @default.
• W2102425178 hasConcept C126322002 @default.
• W2102425178 hasConcept C156957248 @default.
• W2102425178 hasConcept C2776409635 @default.
• W2102425178 hasConcept C2776962512 @default.
• W2102425178 hasConcept C2778155338 @default.
• W2102425178 hasConcept C2778907293 @default.
• W2102425178 hasConcept C2780206985 @default.
• W2102425178 hasConcept C2780356492 @default.
• W2102425178 hasConcept C42219234 @default.
• W2102425178 hasConcept C44249647 @default.
• W2102425178 hasConcept C501593827 @default.
• W2102425178 hasConcept C519063684 @default.
• W2102425178 hasConcept C71924100 @default.
• W2102425178 hasConcept C85520022 @default.
• W2102425178 hasConcept C86803240 @default.
• W2102425178 hasConcept C89423630 @default.
• W2102425178 hasConcept C98274493 @default.
• W2102425178 hasConceptScore W2102425178C126322002 @default.
• W2102425178 hasConceptScore W2102425178C156957248 @default.
• W2102425178 hasConceptScore W2102425178C2776409635 @default.
• W2102425178 hasConceptScore W2102425178C2776962512 @default.
• W2102425178 hasConceptScore W2102425178C2778155338 @default.
• W2102425178 hasConceptScore W2102425178C2778907293 @default.
• W2102425178 hasConceptScore W2102425178C2780206985 @default.
• W2102425178 hasConceptScore W2102425178C2780356492 @default.
• W2102425178 hasConceptScore W2102425178C42219234 @default.
• W2102425178 hasConceptScore W2102425178C44249647 @default.
• W2102425178 hasConceptScore W2102425178C501593827 @default.
• W2102425178 hasConceptScore W2102425178C519063684 @default.
• W2102425178 hasConceptScore W2102425178C71924100 @default.
• W2102425178 hasConceptScore W2102425178C85520022 @default.
• W2102425178 hasConceptScore W2102425178C86803240 @default.
• W2102425178 hasConceptScore W2102425178C89423630 @default.
• W2102425178 hasConceptScore W2102425178C98274493 @default.
• W2102425178 hasIssue "3" @default.
• W2102425178 hasLocation W21024251781 @default.
• W2102425178 hasLocation W21024251782 @default.
• W2102425178 hasLocation W21024251783 @default.
• W2102425178 hasLocation W21024251784 @default.
• W2102425178 hasOpenAccess W2102425178 @default.
• W2102425178 hasPrimaryLocation W21024251781 @default.
• W2102425178 hasRelatedWork W2100406698 @default.

• next