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• W2102428326 abstract "A mutational change of the initiation codon to GUA was found to reduce, but not abolish, expression of the recJ gene of Escherichia coli. Specific mutations in translational initiation factor IF3 have been isolated as second-site suppressors of this GUA initiation codon mutation. One of these, infC135, with an arginine-to-proline change at amino acid 131, completely restores a wild-type phenotype to recJ GUA initiation codon mutants and acts in a semidominant fashion. The infC135 mutation increased expression of RecJ from the GUA mutant but had no effect on the normal GUG start. The infC135 mutation also abolished autoregulation of IF3 in cis and in trans. The behavior of this IF3 mutant suggests that it has specifically lost its ability to abort initiation from poor initiation codons such as GUA of recJ and the AUU of infC. Because of the impact of IF3 on recJ, a recombination and repair gene, this role of IF3 must be general and not restricted to translation genes. The dominance of infC135 suggests that the other functions of IF3, for instance its ability to bind to 30S ribosomes, must remain intact. Although the ability to discriminate among initiation codons has been lost in the infC135 mutant, translational initiation was still restricted to the normal initiation site in recJ, even in the presence of a closely juxtaposed alternative initiation codon. Because the recJ gene lacks a canonical Shine-Dalgarno sequence, other unknown features of the mRNA must serve to specify the initiation site." @default.
• W2102428326 created "2016-06-24" @default.
• W2102428326 creator A5057668669 @default.
• W2102428326 creator A5058249132 @default.
• W2102428326 date "1997-11-01" @default.
• W2102428326 modified "2023-09-26" @default.
• W2102428326 title "IF3-mediated suppression of a GUA initiation codon mutation in the recJ gene of Escherichia coli" @default.
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• W2102428326 doi "https://doi.org/10.1128/jb.179.21.6705-6713.1997" @default.
• W2102428326 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/179599" @default.
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