Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102434562> ?p ?o ?g. }
- W2102434562 endingPage "411" @default.
- W2102434562 startingPage "403" @default.
- W2102434562 abstract "Previous studies have indicated that trichosanthin (TCS) exerts antitumor activity by inducing apoptosis in numerous tumor cell lines. However, the effects of TCS on lymphoma remain to be elucidated. The current study demonstrated that TCS inhibited the proliferation of thirteen lymphoma cell lines in a dose‑dependent manner, with SU‑DHL‑2 cells exhibiting the greatest sensitivity to TCS. Treatment of SU‑DHL‑2 cells with TCS led to cell cycle arrest at the S to G2/M phase transition. Furthermore, flow cytometric analysis, Hoechst 33258 staining and western blotting indicated that TCS induced the apoptosis of SU‑DHL‑2 cells in a time‑ and concentration‑dependent manner. In addition, the activation of caspase‑3 and ‑7 and poly (ADP‑ribose) polymerase were observed. Pharmacological pan-caspase inhibition was observed to reduce TCS‑induced apoptosis. Inhibition of caspase‑8 or ‑9 alone was observed to partially reverse the effect of TCS on apoptosis. In conclusion, the current study indicates that TCS may induce apoptosis in SU‑DHL‑2 cells via the extrinsic and intrinsic pathways." @default.
- W2102434562 created "2016-06-24" @default.
- W2102434562 creator A5001673568 @default.
- W2102434562 creator A5009085305 @default.
- W2102434562 creator A5031344912 @default.
- W2102434562 creator A5042110124 @default.
- W2102434562 creator A5047027216 @default.
- W2102434562 date "2015-11-06" @default.
- W2102434562 modified "2023-10-16" @default.
- W2102434562 title "Trichosanthin reduces the viability of SU-DHL-2 cells via the activation of the extrinsic and intrinsic apoptotic pathways" @default.
- W2102434562 cites W1500396877 @default.
- W2102434562 cites W1969300374 @default.
- W2102434562 cites W1973134864 @default.
- W2102434562 cites W1978442810 @default.
- W2102434562 cites W1980090302 @default.
- W2102434562 cites W1980609763 @default.
- W2102434562 cites W1980792888 @default.
- W2102434562 cites W1986033563 @default.
- W2102434562 cites W1987334332 @default.
- W2102434562 cites W2000505669 @default.
- W2102434562 cites W2012173926 @default.
- W2102434562 cites W2014302193 @default.
- W2102434562 cites W2014983456 @default.
- W2102434562 cites W2022554737 @default.
- W2102434562 cites W2023160304 @default.
- W2102434562 cites W2038114873 @default.
- W2102434562 cites W2055965104 @default.
- W2102434562 cites W2062807002 @default.
- W2102434562 cites W2072646319 @default.
- W2102434562 cites W2077320602 @default.
- W2102434562 cites W2077754831 @default.
- W2102434562 cites W2080486351 @default.
- W2102434562 cites W2080849576 @default.
- W2102434562 cites W2081659165 @default.
- W2102434562 cites W2084697906 @default.
- W2102434562 cites W2085825163 @default.
- W2102434562 cites W2087334661 @default.
- W2102434562 cites W2092447548 @default.
- W2102434562 cites W2094595348 @default.
- W2102434562 cites W2103626309 @default.
- W2102434562 cites W2119800239 @default.
- W2102434562 cites W2126326024 @default.
- W2102434562 cites W2135514753 @default.
- W2102434562 cites W2136885526 @default.
- W2102434562 cites W2147987239 @default.
- W2102434562 cites W2151501496 @default.
- W2102434562 cites W2154710278 @default.
- W2102434562 cites W2159583680 @default.
- W2102434562 cites W2162602733 @default.
- W2102434562 cites W2165721689 @default.
- W2102434562 doi "https://doi.org/10.3892/mmr.2015.4531" @default.
- W2102434562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26548896" @default.
- W2102434562 hasPublicationYear "2015" @default.
- W2102434562 type Work @default.
- W2102434562 sameAs 2102434562 @default.
- W2102434562 citedByCount "11" @default.
- W2102434562 countsByYear W21024345622016 @default.
- W2102434562 countsByYear W21024345622017 @default.
- W2102434562 countsByYear W21024345622018 @default.
- W2102434562 countsByYear W21024345622019 @default.
- W2102434562 countsByYear W21024345622021 @default.
- W2102434562 countsByYear W21024345622022 @default.
- W2102434562 countsByYear W21024345622023 @default.
- W2102434562 crossrefType "journal-article" @default.
- W2102434562 hasAuthorship W2102434562A5001673568 @default.
- W2102434562 hasAuthorship W2102434562A5009085305 @default.
- W2102434562 hasAuthorship W2102434562A5031344912 @default.
- W2102434562 hasAuthorship W2102434562A5042110124 @default.
- W2102434562 hasAuthorship W2102434562A5047027216 @default.
- W2102434562 hasBestOaLocation W21024345621 @default.
- W2102434562 hasConcept C104317684 @default.
- W2102434562 hasConcept C153911025 @default.
- W2102434562 hasConcept C182979987 @default.
- W2102434562 hasConcept C185592680 @default.
- W2102434562 hasConcept C190283241 @default.
- W2102434562 hasConcept C2776624327 @default.
- W2102434562 hasConcept C29537977 @default.
- W2102434562 hasConcept C31573885 @default.
- W2102434562 hasConcept C53227056 @default.
- W2102434562 hasConcept C54355233 @default.
- W2102434562 hasConcept C552990157 @default.
- W2102434562 hasConcept C553184892 @default.
- W2102434562 hasConcept C55493867 @default.
- W2102434562 hasConcept C81885089 @default.
- W2102434562 hasConcept C82381507 @default.
- W2102434562 hasConcept C85265743 @default.
- W2102434562 hasConcept C86803240 @default.
- W2102434562 hasConcept C95444343 @default.
- W2102434562 hasConcept C98424977 @default.
- W2102434562 hasConceptScore W2102434562C104317684 @default.
- W2102434562 hasConceptScore W2102434562C153911025 @default.
- W2102434562 hasConceptScore W2102434562C182979987 @default.
- W2102434562 hasConceptScore W2102434562C185592680 @default.
- W2102434562 hasConceptScore W2102434562C190283241 @default.
- W2102434562 hasConceptScore W2102434562C2776624327 @default.
- W2102434562 hasConceptScore W2102434562C29537977 @default.
- W2102434562 hasConceptScore W2102434562C31573885 @default.
- W2102434562 hasConceptScore W2102434562C53227056 @default.