Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102443304> ?p ?o ?g. }
- W2102443304 endingPage "277" @default.
- W2102443304 startingPage "261" @default.
- W2102443304 abstract "Alpha2HS-glycoprotein/fetuin-A (Ahsg) is a serum protein preventing soft tissue calcification. In trauma and inflammation, Ahsg is down-regulated and therefore considered a negative acute phase protein. Enhancement of Ahsg expression as a protective serum protein is desirable in several diseases including tissue remodelling after trauma and infection, kidney and heart failure, and cancer. Using reporter gene assays in hepatoma cells combined with electrophoretic mobility shift assays we determined that dexamethasone up-regulates hepatic Ahsg. A steroid response unit at position -146/-119 within the mouse Ahsg promoter mediates the glucocorticoid-induced increase of Ahsg mRNA. It binds the hepatocyte nuclear factor 3beta and CCAAT enhancer binding protein beta (C/EBP-beta). The up-regulation is mediated indirectly via glucocorticoid hormone-induced transcriptional up-regulation in C/EBP-beta protein. A high degree of sequence identity in mouse, rat and human Ahsg promoters suggests that the promoter is similarly up-regulated by dexamethasone in all three species. Therefore, our findings suggest that glucocorticoids may be used to enhance the level of Ahsg protein circulating in serum." @default.
- W2102443304 created "2016-06-24" @default.
- W2102443304 creator A5008647034 @default.
- W2102443304 creator A5020084081 @default.
- W2102443304 creator A5028517212 @default.
- W2102443304 creator A5030937901 @default.
- W2102443304 creator A5035879928 @default.
- W2102443304 creator A5038275532 @default.
- W2102443304 creator A5063519629 @default.
- W2102443304 date "2006-04-01" @default.
- W2102443304 modified "2023-10-03" @default.
- W2102443304 title "CCAAT enhancer binding protein β and hepatocyte nuclear factor 3β are necessary and sufficient to mediate dexamethasone-induced up-regulation of alpha2HS-glycoprotein/fetuin-A gene expression" @default.
- W2102443304 cites W109457554 @default.
- W2102443304 cites W1496973986 @default.
- W2102443304 cites W1542464099 @default.
- W2102443304 cites W1566276710 @default.
- W2102443304 cites W1578840628 @default.
- W2102443304 cites W1893164080 @default.
- W2102443304 cites W1913954300 @default.
- W2102443304 cites W1954929088 @default.
- W2102443304 cites W1971275647 @default.
- W2102443304 cites W1973948354 @default.
- W2102443304 cites W1977821533 @default.
- W2102443304 cites W1979783822 @default.
- W2102443304 cites W1984044427 @default.
- W2102443304 cites W1986049089 @default.
- W2102443304 cites W1986368022 @default.
- W2102443304 cites W1990355228 @default.
- W2102443304 cites W2008164620 @default.
- W2102443304 cites W2012405150 @default.
- W2102443304 cites W2012585409 @default.
- W2102443304 cites W2012695680 @default.
- W2102443304 cites W2012960616 @default.
- W2102443304 cites W2013189121 @default.
- W2102443304 cites W2014297339 @default.
- W2102443304 cites W2018569654 @default.
- W2102443304 cites W2021789263 @default.
- W2102443304 cites W2022139626 @default.
- W2102443304 cites W2024181247 @default.
- W2102443304 cites W2026451392 @default.
- W2102443304 cites W2029096523 @default.
- W2102443304 cites W2035399235 @default.
- W2102443304 cites W2035913301 @default.
- W2102443304 cites W2042191722 @default.
- W2102443304 cites W2047842452 @default.
- W2102443304 cites W2050389359 @default.
- W2102443304 cites W2053420699 @default.
- W2102443304 cites W2053477045 @default.
- W2102443304 cites W2057833245 @default.
- W2102443304 cites W2062122576 @default.
- W2102443304 cites W2062356919 @default.
- W2102443304 cites W2069662897 @default.
- W2102443304 cites W2072658888 @default.
- W2102443304 cites W2074489367 @default.
- W2102443304 cites W2082301173 @default.
- W2102443304 cites W209938675 @default.
- W2102443304 cites W2102225039 @default.
- W2102443304 cites W2107115514 @default.
- W2102443304 cites W2108067907 @default.
- W2102443304 cites W2110924026 @default.
- W2102443304 cites W2115114534 @default.
- W2102443304 cites W2133295971 @default.
- W2102443304 cites W2135644295 @default.
- W2102443304 cites W2154497747 @default.
- W2102443304 cites W2154746915 @default.
- W2102443304 cites W2159218587 @default.
- W2102443304 cites W2167455623 @default.
- W2102443304 cites W2317184793 @default.
- W2102443304 cites W2403781257 @default.
- W2102443304 cites W2410556461 @default.
- W2102443304 cites W73472706 @default.
- W2102443304 doi "https://doi.org/10.1677/jme.1.02001" @default.
- W2102443304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16595698" @default.
- W2102443304 hasPublicationYear "2006" @default.
- W2102443304 type Work @default.
- W2102443304 sameAs 2102443304 @default.
- W2102443304 citedByCount "32" @default.
- W2102443304 countsByYear W21024433042012 @default.
- W2102443304 countsByYear W21024433042013 @default.
- W2102443304 countsByYear W21024433042014 @default.
- W2102443304 countsByYear W21024433042015 @default.
- W2102443304 countsByYear W21024433042016 @default.
- W2102443304 countsByYear W21024433042017 @default.
- W2102443304 countsByYear W21024433042018 @default.
- W2102443304 countsByYear W21024433042019 @default.
- W2102443304 countsByYear W21024433042020 @default.
- W2102443304 countsByYear W21024433042021 @default.
- W2102443304 countsByYear W21024433042022 @default.
- W2102443304 crossrefType "journal-article" @default.
- W2102443304 hasAuthorship W2102443304A5008647034 @default.
- W2102443304 hasAuthorship W2102443304A5020084081 @default.
- W2102443304 hasAuthorship W2102443304A5028517212 @default.
- W2102443304 hasAuthorship W2102443304A5030937901 @default.
- W2102443304 hasAuthorship W2102443304A5035879928 @default.
- W2102443304 hasAuthorship W2102443304A5038275532 @default.
- W2102443304 hasAuthorship W2102443304A5063519629 @default.
- W2102443304 hasBestOaLocation W21024433041 @default.
- W2102443304 hasConcept C101762097 @default.