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- W2102454966 abstract "Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals are responsible for acute synovial inflammation but also contribute to cartilage degradation and bone lesions within the joint. They activate multiple signal transduction pathways leading to cell activation and recruitment. Some signalling pathways are activated by both types of crystals, and other pathways may only be activated by one type depending on cell type, namely neutrophils, monocytes, macrophages, synovial fibroblasts, endothelial cells and chondrocytes. Cascades of activated proteins involve cytoplasmic membrane related proteins (FAK complex, Src family tyrosine kinases), but also MAPK and NF-kB pathways, leading to NO, prostanoid and cytokine production, and protease activation. This review will also focus on potential therapeutic targets related to cellular signalling in MSU and CPPD crystal-induced inflammation." @default.
- W2102454966 created "2016-06-24" @default.
- W2102454966 creator A5041517297 @default.
- W2102454966 creator A5060186682 @default.
- W2102454966 date "2005-07-01" @default.
- W2102454966 modified "2023-10-18" @default.
- W2102454966 title "Monosodium urate and calcium pyrophosphate dihydrate (CPPD) crystals, inflammation, and cellular signaling" @default.
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- W2102454966 doi "https://doi.org/10.1016/j.jbspin.2004.12.010" @default.
- W2102454966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15990350" @default.
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