FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102474850> ?p ?o ?g. }

• W2102474850 abstract "Oligo-astheno-teratospermia (sperm of low concentration, reduced motility and increased abnormal morphology) of unknown cause is common and the need for treatment is felt by patients and doctors alike. As a result, a variety of empirical, non-specific treatments have been used in an attempt to improve semen characteristics and fertility. One suggested treatment for idiopathic oligo- and/or asthenospermia is the administration of kallikrein (kallidinogenase), a kinin-releasing enzyme (or kininogenase). Although the kinin system may also be involved in the regulation of spermatogenesis in vivo, a clear mechanism of action is missing. Multiple suggestions on how an increase in kinin levels in the genital tract influences spermatogenesis at the testicular levels have been made by various authors.To determine whether treatment of the male with drugs enhancing kinin levles increases pregnancy rates among couples where failure to conceive has been attributed to idiopathic oligo- and/or asthenospermia. Effects on sperm parameters and sex hormones were studied as secondary outcomes.The Cochrane Subfertility Review Group specialised register of controlled trials was searched.SIxteen RCTs on the therapeutic use of androgens (clomiphene citrate or tamoxifen) in subfertile men were identified. Six trials were excluded.All data were extracted by the first author. Unclear issues were resolved by consensus with the senior author (RL). Data was combined for meta-analysis using Peto odds ratios for dichotomous data or weighted mean difference for continuous data.X AUTHORS' CONCLUSIONS: This review does not provide conclusive proof of effectiveness. The benefit on pregnancy rates suggested by observational studies and low quality controlled trials is not confirmed by more rigorous trials. A modest effect on sperm motility is technically possible but was again not confirmed in the better quality trials. The clinical significance of a modest increase in sperm motility is uncertain. Untill effectiveness is proven, kallikrein should only be used in the context of clinical trials." @default.
• W2102474850 created "2016-06-24" @default.
• W2102474850 creator A5013015450 @default.
• W2102474850 creator A5024646212 @default.
• W2102474850 creator A5037835410 @default.
• W2102474850 creator A5046289039 @default.
• W2102474850 date "1996-10-21" @default.
• W2102474850 modified "2023-10-01" @default.
• W2102474850 title "Kinin-enhancing drugs for unexplained subfertility in men" @default.
• W2102474850 cites W125607184 @default.
• W2102474850 cites W1965468640 @default.
• W2102474850 cites W1966579785 @default.
• W2102474850 cites W1966953116 @default.
• W2102474850 cites W1976640959 @default.
• W2102474850 cites W1991935154 @default.
• W2102474850 cites W2005005161 @default.
• W2102474850 cites W2025033741 @default.
• W2102474850 cites W2050822029 @default.
• W2102474850 cites W2061648581 @default.
• W2102474850 cites W2062800467 @default.
• W2102474850 cites W2065226378 @default.
• W2102474850 cites W2067478809 @default.
• W2102474850 cites W2088580569 @default.
• W2102474850 cites W209869875 @default.
• W2102474850 cites W2106629609 @default.
• W2102474850 cites W2107034815 @default.
• W2102474850 cites W2123167784 @default.
• W2102474850 cites W2128545585 @default.
• W2102474850 cites W22335219 @default.
• W2102474850 cites W2293454901 @default.
• W2102474850 cites W2335643686 @default.
• W2102474850 cites W2339652454 @default.
• W2102474850 cites W2415222450 @default.
• W2102474850 cites W2444454799 @default.
• W2102474850 cites W4298030105 @default.
• W2102474850 cites W62078659 @default.
• W2102474850 doi "https://doi.org/10.1002/14651858.cd000153" @default.
• W2102474850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17636606" @default.
• W2102474850 hasPublicationYear "1996" @default.
• W2102474850 type Work @default.
• W2102474850 sameAs 2102474850 @default.
• W2102474850 citedByCount "7" @default.
• W2102474850 countsByYear W21024748502015 @default.
• W2102474850 countsByYear W21024748502021 @default.
• W2102474850 countsByYear W21024748502023 @default.
• W2102474850 crossrefType "journal-article" @default.
• W2102474850 hasAuthorship W2102474850A5013015450 @default.
• W2102474850 hasAuthorship W2102474850A5024646212 @default.
• W2102474850 hasAuthorship W2102474850A5037835410 @default.
• W2102474850 hasAuthorship W2102474850A5046289039 @default.
• W2102474850 hasConcept C126322002 @default.
• W2102474850 hasConcept C156957248 @default.
• W2102474850 hasConcept C23131810 @default.
• W2102474850 hasConcept C2908647359 @default.
• W2102474850 hasConcept C29456083 @default.
• W2102474850 hasConcept C42407357 @default.
• W2102474850 hasConcept C518429986 @default.
• W2102474850 hasConcept C71924100 @default.
• W2102474850 hasConcept C99454951 @default.
• W2102474850 hasConceptScore W2102474850C126322002 @default.
• W2102474850 hasConceptScore W2102474850C156957248 @default.
• W2102474850 hasConceptScore W2102474850C23131810 @default.
• W2102474850 hasConceptScore W2102474850C2908647359 @default.
• W2102474850 hasConceptScore W2102474850C29456083 @default.
• W2102474850 hasConceptScore W2102474850C42407357 @default.
• W2102474850 hasConceptScore W2102474850C518429986 @default.
• W2102474850 hasConceptScore W2102474850C71924100 @default.
• W2102474850 hasConceptScore W2102474850C99454951 @default.
• W2102474850 hasLocation W21024748501 @default.
• W2102474850 hasLocation W21024748502 @default.
• W2102474850 hasOpenAccess W2102474850 @default.
• W2102474850 hasPrimaryLocation W21024748501 @default.
• W2102474850 hasRelatedWork W1999344589 @default.
• W2102474850 hasRelatedWork W2313076522 @default.
• W2102474850 hasRelatedWork W2765980456 @default.
• W2102474850 hasRelatedWork W2789448498 @default.
• W2102474850 hasRelatedWork W2969155864 @default.
• W2102474850 hasRelatedWork W2976382042 @default.
• W2102474850 hasRelatedWork W2981703979 @default.
• W2102474850 hasRelatedWork W3134028840 @default.
• W2102474850 hasRelatedWork W4284673498 @default.
• W2102474850 hasRelatedWork W2464797648 @default.
• W2102474850 isParatext "false" @default.
• W2102474850 isRetracted "false" @default.
• W2102474850 magId "2102474850" @default.
• W2102474850 workType "article" @default.