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• W2102490828 abstract "Study objective β-Blocker use is associated with coronary artery spasm after cocaine administration but also decreases mortality in patients with myocardial infarction or systolic dysfunction. We conduct a retrospective cohort study to analyze the safety of β-blockers in patients with positive urine toxicology results for cocaine. Methods The cohort consisted of 363 consecutive telemetry and ICU patients who were admitted to a municipal hospital and had positive urine toxicology results for cocaine during a 5-year period (307 patients). Fifteen patients with uncertain history of β-blocker use before admission were excluded. The primary outcome measure was myocardial infarction; secondary outcome measure was inhospital mortality. Logistic regression analysis using generalized estimating equations models and propensity scores compared outcomes. Results β-Blockers were given in 60 of 348 admissions. The incidence of myocardial infarction after administration of β-blocker was significantly lower than without treatment (6.1% versus 26.0%; difference in proportion 19.9%; 95% confidence interval [CI] 10.3% to 30.0%). One of 14 deaths occurred in patients who received β-blockade (incidence 1.7% versus 4.5% without β-blockade; difference in proportion 2.8%; 95% CI –1.2% to 6.7%). Multivariate analysis showed that use of β-blockers significantly reduced the risk of myocardial infarction (odds ratio 0.06; 95% CI 0.01 to 0.61). Conclusion In our cohort, administration of β-blockers was associated with reduction in incidence of myocardial infarction after cocaine use. The benefit of β-blockers on myocardial function may offset the risk of coronary artery spasm. β-Blocker use is associated with coronary artery spasm after cocaine administration but also decreases mortality in patients with myocardial infarction or systolic dysfunction. We conduct a retrospective cohort study to analyze the safety of β-blockers in patients with positive urine toxicology results for cocaine. The cohort consisted of 363 consecutive telemetry and ICU patients who were admitted to a municipal hospital and had positive urine toxicology results for cocaine during a 5-year period (307 patients). Fifteen patients with uncertain history of β-blocker use before admission were excluded. The primary outcome measure was myocardial infarction; secondary outcome measure was inhospital mortality. Logistic regression analysis using generalized estimating equations models and propensity scores compared outcomes. β-Blockers were given in 60 of 348 admissions. The incidence of myocardial infarction after administration of β-blocker was significantly lower than without treatment (6.1% versus 26.0%; difference in proportion 19.9%; 95% confidence interval [CI] 10.3% to 30.0%). One of 14 deaths occurred in patients who received β-blockade (incidence 1.7% versus 4.5% without β-blockade; difference in proportion 2.8%; 95% CI –1.2% to 6.7%). Multivariate analysis showed that use of β-blockers significantly reduced the risk of myocardial infarction (odds ratio 0.06; 95% CI 0.01 to 0.61). In our cohort, administration of β-blockers was associated with reduction in incidence of myocardial infarction after cocaine use. The benefit of β-blockers on myocardial function may offset the risk of coronary artery spasm." @default.
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• W2102490828 date "2008-02-01" @default.
• W2102490828 modified "2023-09-23" @default.
• W2102490828 title "β-Blockers Are Associated With Reduced Risk of Myocardial Infarction After Cocaine Use" @default.
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• W2102490828 doi "https://doi.org/10.1016/j.annemergmed.2007.04.015" @default.
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