Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102496605> ?p ?o ?g. }
- W2102496605 endingPage "507" @default.
- W2102496605 startingPage "499" @default.
- W2102496605 abstract "Using genomic microarray analysis, we sought to identify and annotate differences in the pretraining skeletal muscle transcriptomes among human subjects clustered as nonresponders (Non), modest responders (Mod), and extreme responders (Xtr) based on differential magnitudes of myofiber hypertrophy in response to progressive resistance training (RT) (Non −16 μm 2 , Mod 1,111 μm 2 , or Xtr 2,475 μm 2 ). In prior work, we noted differences among clusters in the prevalence of myogenic stem cells prior to and during RT ( 35 ), and in the translational signaling responses to the first bout of resistance exercise ( 30 ). Here we identified remarkable differences in the pretraining transcript profiles among clusters (8,026 gene transcripts differentially expressed between Xtr and Non, 2,463 between Xtr and Mod, and 1,294 between Mod and Non). Annotated functions and networks of differentially expressed genes suggest Xtr were “primed” to respond to RT through transcriptional regulation, along with a uniquely expressed network of genes involved in skeletal muscle development, while the failed response in Non may have been driven by excessive proinflammatory signaling. Protein follow-up analysis revealed higher basal levels of acetylated histone H3 (K36) in the two responder clusters (Mod, Xtr) compared with Non, and only the responders experienced alterations in the muscle content of select proteins (e.g., α-tubulin, p27 kip ) in response to the first resistance exercise stimulus. Overall, the widely disparate transcriptomes identified prior to RT among the three clusters support the notion that at least some of the interindividual heterogeneity in propensity for RT-induced myofiber hypertrophy is likely predetermined." @default.
- W2102496605 created "2016-06-24" @default.
- W2102496605 creator A5005293260 @default.
- W2102496605 creator A5023538492 @default.
- W2102496605 creator A5029597544 @default.
- W2102496605 creator A5044297249 @default.
- W2102496605 creator A5058873829 @default.
- W2102496605 creator A5078628997 @default.
- W2102496605 date "2013-06-15" @default.
- W2102496605 modified "2023-09-25" @default.
- W2102496605 title "Cluster analysis reveals differential transcript profiles associated with resistance training-induced human skeletal muscle hypertrophy" @default.
- W2102496605 cites W1597446425 @default.
- W2102496605 cites W1951514253 @default.
- W2102496605 cites W1966667302 @default.
- W2102496605 cites W1968147545 @default.
- W2102496605 cites W1973690752 @default.
- W2102496605 cites W1977213772 @default.
- W2102496605 cites W1986164542 @default.
- W2102496605 cites W1987077148 @default.
- W2102496605 cites W2000932018 @default.
- W2102496605 cites W2020541351 @default.
- W2102496605 cites W2022267672 @default.
- W2102496605 cites W2028978365 @default.
- W2102496605 cites W2037578230 @default.
- W2102496605 cites W2051618430 @default.
- W2102496605 cites W2059184753 @default.
- W2102496605 cites W2062602635 @default.
- W2102496605 cites W2097995193 @default.
- W2102496605 cites W2116499762 @default.
- W2102496605 cites W2116566888 @default.
- W2102496605 cites W2118152327 @default.
- W2102496605 cites W2118392869 @default.
- W2102496605 cites W2119032894 @default.
- W2102496605 cites W2123064842 @default.
- W2102496605 cites W2128195376 @default.
- W2102496605 cites W2128507162 @default.
- W2102496605 cites W2131466509 @default.
- W2102496605 cites W2134348818 @default.
- W2102496605 cites W2143060519 @default.
- W2102496605 cites W2145013117 @default.
- W2102496605 cites W2148274477 @default.
- W2102496605 cites W2153217835 @default.
- W2102496605 cites W2154974068 @default.
- W2102496605 cites W2156360305 @default.
- W2102496605 cites W2156482744 @default.
- W2102496605 cites W2157388197 @default.
- W2102496605 cites W2164418891 @default.
- W2102496605 cites W2164893149 @default.
- W2102496605 cites W2166059867 @default.
- W2102496605 cites W2167033037 @default.
- W2102496605 cites W2175847409 @default.
- W2102496605 cites W3143060430 @default.
- W2102496605 doi "https://doi.org/10.1152/physiolgenomics.00167.2012" @default.
- W2102496605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3680779" @default.
- W2102496605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23632419" @default.
- W2102496605 hasPublicationYear "2013" @default.
- W2102496605 type Work @default.
- W2102496605 sameAs 2102496605 @default.
- W2102496605 citedByCount "83" @default.
- W2102496605 countsByYear W21024966052013 @default.
- W2102496605 countsByYear W21024966052014 @default.
- W2102496605 countsByYear W21024966052015 @default.
- W2102496605 countsByYear W21024966052016 @default.
- W2102496605 countsByYear W21024966052017 @default.
- W2102496605 countsByYear W21024966052018 @default.
- W2102496605 countsByYear W21024966052019 @default.
- W2102496605 countsByYear W21024966052020 @default.
- W2102496605 countsByYear W21024966052021 @default.
- W2102496605 countsByYear W21024966052022 @default.
- W2102496605 countsByYear W21024966052023 @default.
- W2102496605 crossrefType "journal-article" @default.
- W2102496605 hasAuthorship W2102496605A5005293260 @default.
- W2102496605 hasAuthorship W2102496605A5023538492 @default.
- W2102496605 hasAuthorship W2102496605A5029597544 @default.
- W2102496605 hasAuthorship W2102496605A5044297249 @default.
- W2102496605 hasAuthorship W2102496605A5058873829 @default.
- W2102496605 hasAuthorship W2102496605A5078628997 @default.
- W2102496605 hasBestOaLocation W21024966052 @default.
- W2102496605 hasConcept C104317684 @default.
- W2102496605 hasConcept C134018914 @default.
- W2102496605 hasConcept C150194340 @default.
- W2102496605 hasConcept C162317418 @default.
- W2102496605 hasConcept C167414201 @default.
- W2102496605 hasConcept C18431079 @default.
- W2102496605 hasConcept C186836561 @default.
- W2102496605 hasConcept C207200792 @default.
- W2102496605 hasConcept C2779959927 @default.
- W2102496605 hasConcept C54355233 @default.
- W2102496605 hasConcept C8415881 @default.
- W2102496605 hasConcept C86803240 @default.
- W2102496605 hasConcept C95444343 @default.
- W2102496605 hasConceptScore W2102496605C104317684 @default.
- W2102496605 hasConceptScore W2102496605C134018914 @default.
- W2102496605 hasConceptScore W2102496605C150194340 @default.
- W2102496605 hasConceptScore W2102496605C162317418 @default.
- W2102496605 hasConceptScore W2102496605C167414201 @default.
- W2102496605 hasConceptScore W2102496605C18431079 @default.
- W2102496605 hasConceptScore W2102496605C186836561 @default.