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- W2102519027 abstract "Although alterations in plasma testosterone concentration and the hypothalamic-pituitary-gonadal axis are associated with psychiatric disorders and symptoms including mood disorders, psychosis, anger, and aggression, their underlying biological mechanisms of action have been researched only to a very limited extent ( 1 Höfer P. Lanzenberger R. Kasper S. Testosterone in the brain: Neuroimaging findings and the potential role for neuropsychopharmacology. Eur Neuropsychopharmacol. 2013; 23: 79-88 Abstract Full Text Full Text PDF PubMed Scopus (47) Google Scholar ). In contrast, numerous studies in healthy control subjects have revealed the modulating role of testosterone in social and economic interactions and in status-seeking behavior. However, most of these studies were correlational in nature; that is, they provided evidence for associations between physiologic testosterone plasma levels and human behavior or underlying brain function. The lack of causal interpretability of such studies, together with difficult-to-interpret behavioral data from research in nonhuman subjects, has precluded determination of a distinct function of testosterone in human behavior until recently. Testosterone Rapidly Increases Neural Reactivity to Threat in Healthy Men: A Novel Two-Step Pharmacological Challenge ParadigmBiological PsychiatryVol. 76Issue 4PreviewPrevious research suggests that testosterone (T) plays a key role in shaping competitive and aggressive behavior in humans, possibly by modulating threat-related neural circuitry. However, this research has been limited by the use of T augmentation that fails to account for baseline differences and has been conducted exclusively in women. Thus, the extent to which normal physiologic concentrations of T affect threat-related brain function in men remains unknown. Full-Text PDF" @default.
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- W2102519027 date "2014-08-01" @default.
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- W2102519027 title "Testosterone, Neural Circuits, and Male Depression" @default.
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- W2102519027 doi "https://doi.org/10.1016/j.biopsych.2014.06.010" @default.
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