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- W2102552021 abstract "We constructed a library of sugar-dipeptide conjugate to find out the best complementary against hydrophobic pocket of α-glucosidase. The best substrate showed 150-fold improved K(m) value relative p-acetaminophenyl-α-D-glucopyranoside for α-glucosidase from Bacillus stearothermophillus. Using information from the complementary, we synthesized sp-WY and β-Glc-sp-WY, which selectivity inhibited the cognate enzyme." @default.
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- W2102552021 date "2011-04-01" @default.
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- W2102552021 title "Selective α-glucosidase substrates and inhibitors containing short aromatic peptidyl moieties" @default.
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- W2102552021 doi "https://doi.org/10.1016/j.bmcl.2011.02.062" @default.
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