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• W2102553477 abstract "<h3>BACKGROUND</h3> Reports on the impact of a loss in the central field of vision on optokinetic nystagmus (OKN) are varied. A study was therefore undertaken to reassess the role of the central retina in the generation of OKN in a large group of patients with age related macular degeneration. <h3>METHODS</h3> Four groups of 20 patients were examined: a control group without scotoma and three groups with absolute central scotomas measuring 1°–10°, 11°–20°, and 21°–30°. OKN was elicited with black and white stripes moving nasally to temporally or temporally to nasally on a screen subtending 54° × 41° at four velocities (15, 30, 45, and 60°/s). OKN gain was measured using infrared oculography. <h3>RESULTS</h3> There was no significant difference in OKN gain between the control group and those with scotomas of 1°–10° and 11°–20°. A significant difference in OKN gain was found between the group with scotomas of 21°–30° and all other groups at stimulus velocities of 30, 45, and 60°/s (p<0.05). OKN gain significantly diminished with increasing stimulus velocity (p<0.05). No statistically significant difference was found in OKN gain between stimuli moving temporally to nasally and nasally to temporally. <h3>CONCLUSION</h3> Abnormalities of OKN gain were noted only in patients with large scotomas. An intact macula is therefore not necessary for the generation of OKN." @default.
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• W2102553477 date "2001-02-01" @default.
• W2102553477 modified "2023-09-24" @default.
• W2102553477 title "Optokinetic nystagmus in patients with central scotomas in age related macular degeneration" @default.
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• W2102553477 doi "https://doi.org/10.1136/bjo.85.2.169" @default.
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