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• W2102564037 abstract "Background Elevated serum Angptl2 levels are positively associated with the development of type 2 diabetes. We investigated whether serum Angptl2 levels are associated with diabetic nephropathy in patients with type 2 diabetes. Methods Two hundred and thirty patients with type 2 diabetes and 63 healthy controls participated in this cross-sectional study. Subjects with type 2 diabetes were divided into three groups using urinary albumin-to-creatinine ratio (ACR): a normoalbuminuric group (n = 57), a microalbuminuric group (n = 130) and a macroalbuminuria group (n = 43). Serum Angptl2 concentrations were measured by enzyme-linked immunosorbent assay. Results Median serum (interquartile range) Angptl2 levels in control subjects and patients with type 2 diabetes with normoalbuminuria, microalbuminuria and macroalbuminuria were 24.03 (16.3–33.45), 36.14 (27.91–43.07), 44.6 (37.47–49.92), 50.19 (45.95–60.13) ng/ml (p < 0.01) respectively. Angptl2 levels correlated with urinary ACR in participants with type 2 diabetes (r = 0.38, p < 0.01). Significant intercorrelations of Angptl2 were found with age, duration of diabetes, and fasting plasma glucose. After adjustment for significant covariates, albuminuria was still significantly associated with Angptl2 levels in type 2 diabetes (r = 0.31, p < 0.01). Conclusions Angptl2 levels are elevated in patients with type 2 diabetes with an independent association between increasing Angptl2 levels and increasing levels of albuminuria. This suggests a possible role of Angptl2 in progressive nephropathy in patients with type 2 diabetes." @default.
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• W2102564037 date "2013-06-01" @default.
• W2102564037 modified "2023-10-03" @default.
• W2102564037 title "Serum Angptl2 levels are independently associated with albuminuria in type 2 diabetes" @default.
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• W2102564037 doi "https://doi.org/10.1016/j.diabres.2013.03.028" @default.
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