FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102581824> ?p ?o ?g. }

• W2102581824 endingPage "918" @default.
• W2102581824 startingPage "911" @default.
• W2102581824 abstract "In situ hybridisation methods were used to map the distribution of the novel long PDE4A10 isoform in the brain. PDE4A10 distribution was compared to that of the long PDE4A5 isoform and the short PDE4A1 isoform using probes specific for unique sequences within each of these isoforms. Coronal sections of the brain, taken at the level of the olfactory bulb, prefrontal cortex, striatum, thalamus, hippocampus and cerebellum, were analysed. Strongest expression of PDE4A isoforms was found in the olfactory bulb granular layer with high signals also in the piriform cortex, the dentate gyrus and the CA1 and CA2 pyramidal cells. For the two long forms, level general staining was noted throughout the striatum, thalamus and hippocampus but no signal was evident in the cerebellum. The long PDE4A10 and PDE4A5 isoforms localised to essentially the same regions throughout the brain, although PDE4A10 was uniquely expressed in the major island of Calleja. A signal for the short PDE4A1 isoform was found in regions in which the two long isoforms were both expressed, with the exception of the medial nucleus of the amygdala where weak signals for PDE4A5 and PDE4A10 were detected but PDE4A1 was absent. Uniquely, strong signals for PDE4A1 were detected in the glomerular layer of the olfactory bulb, the CA3 pyramidal cell region and the cerebellum; areas where signals for the two long forms were not evident. PDE4A transcripts for both PDE4A5 and PDE4A10 were not apparent in the brain stem and those for PDE4A1 were low. PDE4A isoforms are present in several key areas of the brain and therefore present valid targets for therapeutic interventions. Whilst the two long PDE4A isoforms show a remarkably similar distribution, in at least three regions there is clear segregation between their pattern of expression and that of the PDE4A1 short form. This identifies differential regulation of the expression of PDE4A long and short isoforms. We suggest that specific PDE4A isoforms may have distinct functional roles in the brain, indicating that PDE4A isoform-selective inhibitors may have specific therapeutic and pharmacologic properties." @default.
• W2102581824 created "2016-06-24" @default.
• W2102581824 creator A5055355105 @default.
• W2102581824 creator A5081669989 @default.
• W2102581824 creator A5082791153 @default.
• W2102581824 date "2001-12-01" @default.
• W2102581824 modified "2023-10-10" @default.
• W2102581824 title "The novel long PDE4A10 cyclic AMP phosphodiesterase shows a pattern of expression within brain that is distinct from the long PDE4A5 and short PDE4A1 isoforms" @default.
• W2102581824 cites W1482358500 @default.
• W2102581824 cites W1499000998 @default.
• W2102581824 cites W1510434099 @default.
• W2102581824 cites W1516500578 @default.
• W2102581824 cites W1526922448 @default.
• W2102581824 cites W1576022142 @default.
• W2102581824 cites W1867514631 @default.
• W2102581824 cites W1885709862 @default.
• W2102581824 cites W1887032383 @default.
• W2102581824 cites W1967220625 @default.
• W2102581824 cites W1968189883 @default.
• W2102581824 cites W1968946845 @default.
• W2102581824 cites W1974595085 @default.
• W2102581824 cites W1977275444 @default.
• W2102581824 cites W1977774316 @default.
• W2102581824 cites W1978217907 @default.
• W2102581824 cites W1979750912 @default.
• W2102581824 cites W1980676029 @default.
• W2102581824 cites W1995659501 @default.
• W2102581824 cites W2002029595 @default.
• W2102581824 cites W2013326794 @default.
• W2102581824 cites W2016270023 @default.
• W2102581824 cites W2025440577 @default.
• W2102581824 cites W2037901002 @default.
• W2102581824 cites W2040522714 @default.
• W2102581824 cites W2046754637 @default.
• W2102581824 cites W2047549229 @default.
• W2102581824 cites W2057662508 @default.
• W2102581824 cites W2067603720 @default.
• W2102581824 cites W2069328624 @default.
• W2102581824 cites W2071782304 @default.
• W2102581824 cites W2078037416 @default.
• W2102581824 cites W2081234675 @default.
• W2102581824 cites W2084173546 @default.
• W2102581824 cites W2084783054 @default.
• W2102581824 cites W2087526026 @default.
• W2102581824 cites W2088950166 @default.
• W2102581824 cites W2089770153 @default.
• W2102581824 cites W2091546980 @default.
• W2102581824 cites W2092052750 @default.
• W2102581824 cites W2096286070 @default.
• W2102581824 cites W2106753244 @default.
• W2102581824 cites W2124493262 @default.
• W2102581824 cites W2137252488 @default.
• W2102581824 cites W2152887599 @default.
• W2102581824 cites W2154321127 @default.
• W2102581824 cites W2158574592 @default.
• W2102581824 cites W2164744404 @default.
• W2102581824 cites W2167689408 @default.
• W2102581824 cites W2201412268 @default.
• W2102581824 cites W2222613180 @default.
• W2102581824 cites W2223880767 @default.
• W2102581824 cites W2224383058 @default.
• W2102581824 cites W2301214492 @default.
• W2102581824 cites W2341366090 @default.
• W2102581824 cites W2388494150 @default.
• W2102581824 cites W4235055140 @default.
• W2102581824 cites W4256064074 @default.
• W2102581824 doi "https://doi.org/10.1016/s0898-6568(01)00217-0" @default.
• W2102581824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11728831" @default.
• W2102581824 hasPublicationYear "2001" @default.
• W2102581824 type Work @default.
• W2102581824 sameAs 2102581824 @default.
• W2102581824 citedByCount "42" @default.
• W2102581824 countsByYear W21025818242012 @default.
• W2102581824 countsByYear W21025818242013 @default.
• W2102581824 countsByYear W21025818242014 @default.
• W2102581824 countsByYear W21025818242015 @default.
• W2102581824 countsByYear W21025818242016 @default.
• W2102581824 countsByYear W21025818242017 @default.
• W2102581824 countsByYear W21025818242018 @default.
• W2102581824 countsByYear W21025818242019 @default.
• W2102581824 countsByYear W21025818242020 @default.
• W2102581824 countsByYear W21025818242021 @default.
• W2102581824 countsByYear W21025818242023 @default.
• W2102581824 crossrefType "journal-article" @default.
• W2102581824 hasAuthorship W2102581824A5055355105 @default.
• W2102581824 hasAuthorship W2102581824A5081669989 @default.
• W2102581824 hasAuthorship W2102581824A5082791153 @default.
• W2102581824 hasConcept C104317684 @default.
• W2102581824 hasConcept C110726550 @default.
• W2102581824 hasConcept C169760540 @default.
• W2102581824 hasConcept C2776464000 @default.
• W2102581824 hasConcept C2778340768 @default.
• W2102581824 hasConcept C2778437258 @default.
• W2102581824 hasConcept C2779246727 @default.
• W2102581824 hasConcept C2779652256 @default.
• W2102581824 hasConcept C2780062018 @default.
• W2102581824 hasConcept C2780382662 @default.
• W2102581824 hasConcept C2780496858 @default.

• next