FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102581852> ?p ?o ?g. }

• W2102581852 abstract "Insulin resistance (IR) is an established risk factor for colorectal cancer (CRC). Given that CRC and IR physiologically overlap and the calpain-10 gene (CAPN10) is a candidate for IR, we explored the association between CAPN10 and CRC risk.Blood samples of 400 case-control pairs were genotyped, and the lifestyle and dietary habits of these pairs were recorded and collected. Unconditional logistic regression (LR) was used to assess the effects of CAPN10 SNP43 and SNP19, and environmental factors. Both generalized multifactor dimensionality reduction (GMDR) and the classification and regression tree (CART) were used to test gene-environment interactions for CRC risk.The GA+AA genotype of SNP43 and the Del/Ins+Ins/Ins genotype of SNP19 were marginally related to CRC risk (GA+AA: OR = 1.35, 95% CI = 0.92-1.99; Del/Ins+Ins/ Ins: OR = 1.31, 95% CI = 0.84-2.04). Notably, a high-order interaction was consistently identified by GMDR and CART analyses. In GMDR, the four-factor interaction model of SNP43, SNP19, red meat consumption, and smoked meat consumption was the best model, with a maximum cross-validation consistency of 10/10 and testing balance accuracy of 0.61 (P < 0.01). In LR, subjects with high red and smoked meat consumption and two risk genotypes had a 6.17-fold CRC risk (95% CI = 2.44-15.6) relative to that of subjects with low red and smoked meat consumption and null risk genotypes. In CART, individuals with high smoked and red meat consumption, SNP19 Del/Ins+Ins/Ins, and SNP43 GA+AA had higher CRC risk (OR = 4.56, 95%CI = 1.94-10.75) than those with low smoked and red meat consumption.Though the single loci of CAPN10 SNP43 and SNP19 are not enough to significantly increase the CRC susceptibility, the combination of SNP43, SNP19, red meat consumption, and smoked meat consumption is associated with elevated risk." @default.
• W2102581852 created "2016-06-24" @default.
• W2102581852 creator A5009438700 @default.
• W2102581852 creator A5013902519 @default.
• W2102581852 creator A5021062512 @default.
• W2102581852 creator A5032162374 @default.
• W2102581852 creator A5038829533 @default.
• W2102581852 creator A5060856715 @default.
• W2102581852 creator A5068916530 @default.
• W2102581852 creator A5071405911 @default.
• W2102581852 date "2013-11-30" @default.
• W2102581852 modified "2023-09-26" @default.
• W2102581852 title "Calpain-10 SNP43 and SNP19 Polymorphisms and Colorectal Cancer: a Matched Case-control Study" @default.
• W2102581852 cites W1543891416 @default.
• W2102581852 cites W1574047547 @default.
• W2102581852 cites W1592727028 @default.
• W2102581852 cites W17208169 @default.
• W2102581852 cites W1911408918 @default.
• W2102581852 cites W1950443258 @default.
• W2102581852 cites W1961967618 @default.
• W2102581852 cites W1968278222 @default.
• W2102581852 cites W1969025116 @default.
• W2102581852 cites W1973447662 @default.
• W2102581852 cites W1976634586 @default.
• W2102581852 cites W1976735484 @default.
• W2102581852 cites W1976913734 @default.
• W2102581852 cites W1982539838 @default.
• W2102581852 cites W1992729193 @default.
• W2102581852 cites W1992742783 @default.
• W2102581852 cites W1993376998 @default.
• W2102581852 cites W1996795377 @default.
• W2102581852 cites W1998473127 @default.
• W2102581852 cites W2002699471 @default.
• W2102581852 cites W2003578093 @default.
• W2102581852 cites W2011132777 @default.
• W2102581852 cites W2021876362 @default.
• W2102581852 cites W2023736002 @default.
• W2102581852 cites W2028996544 @default.
• W2102581852 cites W2030159961 @default.
• W2102581852 cites W2034478850 @default.
• W2102581852 cites W2036170156 @default.
• W2102581852 cites W2037366622 @default.
• W2102581852 cites W2060730208 @default.
• W2102581852 cites W2067944947 @default.
• W2102581852 cites W2084977733 @default.
• W2102581852 cites W2085692972 @default.
• W2102581852 cites W2089171551 @default.
• W2102581852 cites W2091069585 @default.
• W2102581852 cites W2096007910 @default.
• W2102581852 cites W2098692754 @default.
• W2102581852 cites W2101587427 @default.
• W2102581852 cites W2101935830 @default.
• W2102581852 cites W2103421704 @default.
• W2102581852 cites W2106489922 @default.
• W2102581852 cites W2129222347 @default.
• W2102581852 cites W2149227688 @default.
• W2102581852 cites W2151148306 @default.
• W2102581852 cites W2161381121 @default.
• W2102581852 cites W2164715971 @default.
• W2102581852 cites W2167874330 @default.
• W2102581852 cites W2169436026 @default.
• W2102581852 cites W2170579693 @default.
• W2102581852 cites W2170769700 @default.
• W2102581852 cites W2313448551 @default.
• W2102581852 cites W2320070551 @default.
• W2102581852 cites W2760117593 @default.
• W2102581852 cites W2916161913 @default.
• W2102581852 doi "https://doi.org/10.7314/apjcp.2013.14.11.6673" @default.
• W2102581852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24377587" @default.
• W2102581852 hasPublicationYear "2013" @default.
• W2102581852 type Work @default.
• W2102581852 sameAs 2102581852 @default.
• W2102581852 citedByCount "6" @default.
• W2102581852 countsByYear W21025818522014 @default.
• W2102581852 countsByYear W21025818522019 @default.
• W2102581852 countsByYear W21025818522020 @default.
• W2102581852 crossrefType "journal-article" @default.
• W2102581852 hasAuthorship W2102581852A5009438700 @default.
• W2102581852 hasAuthorship W2102581852A5013902519 @default.
• W2102581852 hasAuthorship W2102581852A5021062512 @default.
• W2102581852 hasAuthorship W2102581852A5032162374 @default.
• W2102581852 hasAuthorship W2102581852A5038829533 @default.
• W2102581852 hasAuthorship W2102581852A5060856715 @default.
• W2102581852 hasAuthorship W2102581852A5068916530 @default.
• W2102581852 hasAuthorship W2102581852A5071405911 @default.
• W2102581852 hasBestOaLocation W21025818521 @default.
• W2102581852 hasConcept C104317684 @default.
• W2102581852 hasConcept C121608353 @default.
• W2102581852 hasConcept C126322002 @default.
• W2102581852 hasConcept C127413603 @default.
• W2102581852 hasConcept C135763542 @default.
• W2102581852 hasConcept C142724271 @default.
• W2102581852 hasConcept C143998085 @default.
• W2102581852 hasConcept C146304588 @default.
• W2102581852 hasConcept C151956035 @default.
• W2102581852 hasConcept C153209595 @default.
• W2102581852 hasConcept C25249476 @default.
• W2102581852 hasConcept C2777275308 @default.
• W2102581852 hasConcept C2778089274 @default.
• W2102581852 hasConcept C526805850 @default.

• next