FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102583849> ?p ?o ?g. }

• W2102583849 endingPage "1249" @default.
• W2102583849 startingPage "1243" @default.
• W2102583849 abstract "Neurotoxicity is becoming increasingly recognized as the major dose-limiting toxicity of oxaliplatin. Because the mechanism of oxaliplatin-induced neurotoxicity remains unclear, the present study investigated the potential of axonal excitability techniques in identifying pathophysiologic mechanisms and early markers of nerve dysfunction.Measures of sensory axonal excitability were recorded before and after infusion over 88 treatment cycles in 25 patients with colorectal cancer, who received a total oxaliplatin dose of 766 +/- 56 mg/m(2). Neurologic assessment, clinical rating scales, and routine nerve conduction studies were performed.By completion of treatment, 16% of patients had developed severe (grade 3) neurotoxicity, and oxaliplatin dose reduction or cessation as a result of neurotoxicity was required in 40% of patients. Changes in axonal excitability occurred after infusion and could be explained on the basis of alterations in axonal membrane sodium (Na+) channel function (refractoriness: 7.6% +/- 1.7% before infusion v 4.5% +/- 1.4% after infusion; P = .03; superexcitability: -22.8% +/- 0.8% before infusion v -20.1% +/- 1.1% after infusion; P = .0002). Changes became less pronounced in later treatment cycles, suggesting that chronic nerve dysfunction and sensory loss masked acute effects at higher cumulative doses. Importantly, patients who demonstrated reductions in superexcitability in early treatment were subsequently more likely to develop moderate to severe neurotoxicity. The findings suggest that the degree of acute nerve dysfunction may relate to the development of chronic neurotoxicity.Sensory axonal excitability techniques may facilitate identification of Na+ channel dysfunction in oxaliplatin-induced neurotoxicity and thereby provide a method to identify patients at risk for neurotoxicity to target those most likely to benefit from future neuroprotective strategies." @default.
• W2102583849 created "2016-06-24" @default.
• W2102583849 creator A5005224523 @default.
• W2102583849 creator A5011795261 @default.
• W2102583849 creator A5021894535 @default.
• W2102583849 creator A5048164891 @default.
• W2102583849 creator A5060424866 @default.
• W2102583849 creator A5068370796 @default.
• W2102583849 date "2009-03-10" @default.
• W2102583849 modified "2023-10-17" @default.
• W2102583849 title "Acute Abnormalities of Sensory Nerve Function Associated With Oxaliplatin-Induced Neurotoxicity" @default.
• W2102583849 cites W1571883215 @default.
• W2102583849 cites W1965967022 @default.
• W2102583849 cites W1968626722 @default.
• W2102583849 cites W1972248724 @default.
• W2102583849 cites W1978123764 @default.
• W2102583849 cites W1981465968 @default.
• W2102583849 cites W1981670005 @default.
• W2102583849 cites W1993259580 @default.
• W2102583849 cites W2012330364 @default.
• W2102583849 cites W2013173477 @default.
• W2102583849 cites W2024892541 @default.
• W2102583849 cites W2039638735 @default.
• W2102583849 cites W2043112113 @default.
• W2102583849 cites W2044309123 @default.
• W2102583849 cites W2046174716 @default.
• W2102583849 cites W2050598006 @default.
• W2102583849 cites W2055241344 @default.
• W2102583849 cites W2057913235 @default.
• W2102583849 cites W2062513416 @default.
• W2102583849 cites W2080382070 @default.
• W2102583849 cites W2100817237 @default.
• W2102583849 cites W2108916282 @default.
• W2102583849 cites W2113919377 @default.
• W2102583849 cites W2115504814 @default.
• W2102583849 cites W2120713475 @default.
• W2102583849 cites W2121368761 @default.
• W2102583849 cites W2121543823 @default.
• W2102583849 cites W2123522220 @default.
• W2102583849 cites W2132840373 @default.
• W2102583849 cites W2139687160 @default.
• W2102583849 cites W2140673825 @default.
• W2102583849 cites W2148622949 @default.
• W2102583849 cites W2152706544 @default.
• W2102583849 cites W2163648204 @default.
• W2102583849 cites W2164416822 @default.
• W2102583849 cites W2168506147 @default.
• W2102583849 cites W2171039931 @default.
• W2102583849 cites W2171232394 @default.
• W2102583849 cites W2175773713 @default.
• W2102583849 cites W2183615977 @default.
• W2102583849 cites W86539229 @default.
• W2102583849 doi "https://doi.org/10.1200/jco.2008.19.3425" @default.
• W2102583849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19164207" @default.
• W2102583849 hasPublicationYear "2009" @default.
• W2102583849 type Work @default.
• W2102583849 sameAs 2102583849 @default.
• W2102583849 citedByCount "145" @default.
• W2102583849 countsByYear W21025838492012 @default.
• W2102583849 countsByYear W21025838492013 @default.
• W2102583849 countsByYear W21025838492014 @default.
• W2102583849 countsByYear W21025838492015 @default.
• W2102583849 countsByYear W21025838492016 @default.
• W2102583849 countsByYear W21025838492017 @default.
• W2102583849 countsByYear W21025838492018 @default.
• W2102583849 countsByYear W21025838492019 @default.
• W2102583849 countsByYear W21025838492020 @default.
• W2102583849 countsByYear W21025838492021 @default.
• W2102583849 countsByYear W21025838492022 @default.
• W2102583849 countsByYear W21025838492023 @default.
• W2102583849 crossrefType "journal-article" @default.
• W2102583849 hasAuthorship W2102583849A5005224523 @default.
• W2102583849 hasAuthorship W2102583849A5011795261 @default.
• W2102583849 hasAuthorship W2102583849A5021894535 @default.
• W2102583849 hasAuthorship W2102583849A5048164891 @default.
• W2102583849 hasAuthorship W2102583849A5060424866 @default.
• W2102583849 hasAuthorship W2102583849A5068370796 @default.
• W2102583849 hasBestOaLocation W21025838491 @default.
• W2102583849 hasConcept C121608353 @default.
• W2102583849 hasConcept C126322002 @default.
• W2102583849 hasConcept C178790620 @default.
• W2102583849 hasConcept C185592680 @default.
• W2102583849 hasConcept C2776414672 @default.
• W2102583849 hasConcept C2779491297 @default.
• W2102583849 hasConcept C2780962732 @default.
• W2102583849 hasConcept C29730261 @default.
• W2102583849 hasConcept C42219234 @default.
• W2102583849 hasConcept C50952357 @default.
• W2102583849 hasConcept C526805850 @default.
• W2102583849 hasConcept C537181965 @default.
• W2102583849 hasConcept C71924100 @default.
• W2102583849 hasConceptScore W2102583849C121608353 @default.
• W2102583849 hasConceptScore W2102583849C126322002 @default.
• W2102583849 hasConceptScore W2102583849C178790620 @default.
• W2102583849 hasConceptScore W2102583849C185592680 @default.
• W2102583849 hasConceptScore W2102583849C2776414672 @default.
• W2102583849 hasConceptScore W2102583849C2779491297 @default.
• W2102583849 hasConceptScore W2102583849C2780962732 @default.

• next