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- W2102584543 abstract "Until the 1980s, little attention had been accorded to endemic Kaposi's sarcoma (KS), a neoplasm noted in several parts of Southern Europe and the African continent but with relatively slow progression, except in children and young adults. Furthermore, therapeutic approaches based on surgery, radiation and topical treatment were of limited efficacy, mostly used to overcome the disabling and stigmatizing effects of the disease. With the emergence of the HIV/AIDS epidemic, and the profound impact of KS on AIDS-related mortality, the pathogenesis of KS has been better studied, and the realisation that a virus (KS-associated Herpesvirus or Human Herpesvirus 8, or KSHV/HHV-8), combined with immunosuppression and cytokine-induced growth, was responsible for the development of this disease has led to novel therapeutic approaches. These are unfortunately still highly toxic, require careful monitoring, and are expensive, thus limiting their use in most parts of Africa. However, the use of highly active antiretroviral therapy (HAART), which has led to a considerable decline in KS incidence in populations of industrialized countries, constitutes the best hope for the control of this stigmatizing and lethal disease in Africa. Trials comparing different regimens of antiretroviral drugs in combination with systemic chemotherapeutic agents are urgently needed." @default.
- W2102584543 created "2016-06-24" @default.
- W2102584543 creator A5003888696 @default.
- W2102584543 creator A5018999556 @default.
- W2102584543 date "2005-09-06" @default.
- W2102584543 modified "2023-10-15" @default.
- W2102584543 title "AIDS-related Kaposi's sarcoma: epidemiological, diagnostic, treatment and control aspects in sub-Saharan Africa" @default.
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- W2102584543 doi "https://doi.org/10.1111/j.1365-3156.2005.01491.x" @default.
- W2102584543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16185232" @default.
- W2102584543 hasPublicationYear "2005" @default.
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