FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102585212> ?p ?o ?g. }

• W2102585212 abstract "The clinical use of BRAF inhibitors for treatment of metastatic melanoma is limited by the development of drug resistance. In this study we investigated whether co-targeting the MAPK and the PI3K-AKT pathway can prevent emergence of resistance or provide additional growth inhibitory effects in vitro. Anti-tumor effects of the combination of the BRAF inhibitor (BRAFi) dabrafenib and GSK2141795B (AKTi) in a panel of 23 BRAF mutated melanoma cell lines were evaluated on growth inhibition by an ATP-based luminescent assay, on cell cycle and apoptosis by flow cytometry and on cell signaling by western blot. Moreover, we investigated the possibilities of delaying or reversing resistance or achieving further growth inhibition by combining AKTi with dabrafenib and/or the MEK inhibitor (MEKi) trametinib by using long term cultures. More than 40% of the cell lines, including PTEN-/- and AKT mutants showed sensitivity to AKTi (IC50 < 1.5 μM). The combination of dabrafenib and AKTi synergistically potentiated growth inhibition in the majority of cell lines with IC50 > 5 nM dabrafenib. Combinatorial treatment induced apoptosis only in cell lines sensitive to AKTi. In long term cultures of a PTEN-/- cell line, combinatorial treatment with the MAPK inhibitors, dabrafenib and trametinib, and AKTi markedly delayed the emergence of drug resistance. Moreover, combining AKTi with the MAPK inhibitors from the beginning provided superior growth inhibitory effects compared to addition of AKTi upon development of resistance to MAPK inhibitors in this particular cell line. AKTi combined with BRAFi-based therapy may benefit patients with tumors harboring BRAF mutations and particularly PTEN deletions or AKT mutations." @default.
• W2102585212 created "2016-06-24" @default.
• W2102585212 creator A5013245039 @default.
• W2102585212 creator A5017440876 @default.
• W2102585212 creator A5041566361 @default.
• W2102585212 creator A5058393482 @default.
• W2102585212 creator A5083745558 @default.
• W2102585212 creator A5089165183 @default.
• W2102585212 creator A5091569690 @default.
• W2102585212 date "2014-04-16" @default.
• W2102585212 modified "2023-10-13" @default.
• W2102585212 title "Effects of AKT inhibitor therapy in response and resistance to BRAF inhibition in melanoma" @default.
• W2102585212 cites W128422138 @default.
• W2102585212 cites W1605988205 @default.
• W2102585212 cites W1971947883 @default.
• W2102585212 cites W1980906814 @default.
• W2102585212 cites W1985424846 @default.
• W2102585212 cites W1991867384 @default.
• W2102585212 cites W2004010079 @default.
• W2102585212 cites W2007867839 @default.
• W2102585212 cites W2009642188 @default.
• W2102585212 cites W2010298858 @default.
• W2102585212 cites W2014096417 @default.
• W2102585212 cites W2017187984 @default.
• W2102585212 cites W2032099289 @default.
• W2102585212 cites W2032211985 @default.
• W2102585212 cites W2032751670 @default.
• W2102585212 cites W2038264590 @default.
• W2102585212 cites W2043058822 @default.
• W2102585212 cites W2053473615 @default.
• W2102585212 cites W2066179587 @default.
• W2102585212 cites W2071525523 @default.
• W2102585212 cites W2081673273 @default.
• W2102585212 cites W2100614336 @default.
• W2102585212 cites W2100887597 @default.
• W2102585212 cites W2102686544 @default.
• W2102585212 cites W2103557568 @default.
• W2102585212 cites W2105660237 @default.
• W2102585212 cites W2106543129 @default.
• W2102585212 cites W2108360575 @default.
• W2102585212 cites W2108537717 @default.
• W2102585212 cites W2111689182 @default.
• W2102585212 cites W2127429864 @default.
• W2102585212 cites W2131040858 @default.
• W2102585212 cites W2135131549 @default.
• W2102585212 cites W2137705897 @default.
• W2102585212 cites W2141674733 @default.
• W2102585212 cites W2156078931 @default.
• W2102585212 cites W2159990074 @default.
• W2102585212 cites W2161249280 @default.
• W2102585212 cites W2166262263 @default.
• W2102585212 cites W2168143310 @default.
• W2102585212 doi "https://doi.org/10.1186/1476-4598-13-83" @default.
• W2102585212 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4021505" @default.
• W2102585212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24735930" @default.
• W2102585212 hasPublicationYear "2014" @default.
• W2102585212 type Work @default.
• W2102585212 sameAs 2102585212 @default.
• W2102585212 citedByCount "64" @default.
• W2102585212 countsByYear W21025852122014 @default.
• W2102585212 countsByYear W21025852122015 @default.
• W2102585212 countsByYear W21025852122016 @default.
• W2102585212 countsByYear W21025852122017 @default.
• W2102585212 countsByYear W21025852122018 @default.
• W2102585212 countsByYear W21025852122019 @default.
• W2102585212 countsByYear W21025852122020 @default.
• W2102585212 countsByYear W21025852122021 @default.
• W2102585212 countsByYear W21025852122022 @default.
• W2102585212 countsByYear W21025852122023 @default.
• W2102585212 crossrefType "journal-article" @default.
• W2102585212 hasAuthorship W2102585212A5013245039 @default.
• W2102585212 hasAuthorship W2102585212A5017440876 @default.
• W2102585212 hasAuthorship W2102585212A5041566361 @default.
• W2102585212 hasAuthorship W2102585212A5058393482 @default.
• W2102585212 hasAuthorship W2102585212A5083745558 @default.
• W2102585212 hasAuthorship W2102585212A5089165183 @default.
• W2102585212 hasAuthorship W2102585212A5091569690 @default.
• W2102585212 hasBestOaLocation W21025852121 @default.
• W2102585212 hasConcept C190283241 @default.
• W2102585212 hasConcept C2776131300 @default.
• W2102585212 hasConcept C2777609662 @default.
• W2102585212 hasConcept C2777658100 @default.
• W2102585212 hasConcept C2778472372 @default.
• W2102585212 hasConcept C2778830669 @default.
• W2102585212 hasConcept C2779707156 @default.
• W2102585212 hasConcept C2781249067 @default.
• W2102585212 hasConcept C2994587330 @default.
• W2102585212 hasConcept C502942594 @default.
• W2102585212 hasConcept C54355233 @default.
• W2102585212 hasConcept C55493867 @default.
• W2102585212 hasConcept C57074206 @default.
• W2102585212 hasConcept C62112901 @default.
• W2102585212 hasConcept C62478195 @default.
• W2102585212 hasConcept C75217442 @default.
• W2102585212 hasConcept C81885089 @default.
• W2102585212 hasConcept C86554907 @default.
• W2102585212 hasConcept C86803240 @default.
• W2102585212 hasConcept C95444343 @default.
• W2102585212 hasConceptScore W2102585212C190283241 @default.
• W2102585212 hasConceptScore W2102585212C2776131300 @default.

• next