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• W2102585440 abstract "Non-adherence to medications is prevalent across all medical conditions that include ambulatory pharmacotherapy and is thus a major barrier to achieving the benefits of otherwise effective medicines. The objective of this systematic review was to identify and to compare the efficacy of strategies and components thereof that improve implementation of the prescribed drug dosing regimen and maintain long-term persistence, based on quantitative evaluation of effect sizes across the aggregated trials. MEDLINE, EMBASE, CINAHL, the Cochrane Library, and PsycINFO were systematically searched for randomized controlled trials that tested the efficacy of adherence-enhancing strategies with self-administered medications. The searches were limited to papers in the English language and were included from database inception to 31 December 2011. Our review included randomized controlled trials in which adherence was assessed by electronically compiled drug dosing histories. Five thousand four hundred studies were screened. Eligibility assessment was performed independently by two reviewers. A structured data collection sheet was developed to extract data from each study. The adherence-enhancing components were classified in eight categories. Quality of the papers was assessed using the criteria of the Cochrane Handbook for Systematic Reviews of Interventions guidelines to assess potential bias. A combined adherence outcome was derived from the different adherence variables available in the studies by extracting from each paper the available adherence summary variables in a pre-defined order (correct dosing, taking adherence, timing adherence, percentage of adherent patients). To study the association between the adherence-enhancing components and their effect on adherence, a linear meta-regression model, based on mean adherence point estimates, and a meta-analysis were conducted. Seventy-nine clinical trials published between 1995 and December 2011 were included in the review. Patients randomized to an intervention group had an average combined adherence outcome of 74.3 %, which was 14.1 % higher than in patients randomized to the control group (60.2 %). The linear meta-regression analysis with stepwise variable selection estimated an 8.8 % increase in adherence when the intervention included feedback to the patients of their recent dosing history (EM-feedback) (p < 0.01) and a 5.0 % increase in adherence when the intervention included a cognitive-educational component (p = 0.02). In addition, the effect of interventions on adherence decreased by 1.1 % each month. Sensitivity analysis by selecting only high-quality papers confirmed the robustness of the model. The random effects model in the meta-analysis, conducted on 48 studies, confirmed the above findings and showed that the improvement in adherence was 19.8 % (95 % CI 10.7–28.9 %) among patients receiving EM-feedback, almost double the improvement in adherence for studies that did not include this type of feedback [10.3 % (95 % CI 7.5–13.1 %)] (p < 0.01). The improvement in adherence was 16.1 % (95 % CI 10.7–21.6 %) in studies that tested cognitive-educational components versus 10.1 % (95 % CI 6.6–13.6 %) in studies that did not include this type of intervention (p = 0.04). Among 57 studies measuring clinical outcomes, only 8 reported a significant improvement in clinical outcome. Despite a common measurement, the meta-analysis was limited by the heterogeneity of the pooled data and the different measures of medication adherence. The funnel plot showed a possible publication bias in studies with high variability of the intervention effect. Notwithstanding the statistical heterogeneity among the studies identified, and potential publication bias, the evidence from our meta-analysis suggests that EM-feedback and cognitive-educational interventions are potentially effective approaches to enhance patient adherence to medications. The limitations of this research highlight the urgent need to define guidelines and study characteristics for research protocols that can guide researchers in designing studies to assess the effects of adherence-enhancing interventions." @default.
• W2102585440 created "2016-06-24" @default.
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• W2102585440 date "2013-04-16" @default.
• W2102585440 modified "2023-10-09" @default.
• W2102585440 title "Identification and Assessment of Adherence-Enhancing Interventions in Studies Assessing Medication Adherence Through Electronically Compiled Drug Dosing Histories: A Systematic Literature Review and Meta-Analysis" @default.
• W2102585440 cites W1887253310 @default.
• W2102585440 cites W1963759527 @default.
• W2102585440 cites W1964491414 @default.
• W2102585440 cites W1968226582 @default.
• W2102585440 cites W1969090911 @default.
• W2102585440 cites W1970957826 @default.
• W2102585440 cites W1972966333 @default.
• W2102585440 cites W1975946012 @default.
• W2102585440 cites W1978842362 @default.
• W2102585440 cites W1980156644 @default.
• W2102585440 cites W1981993792 @default.
• W2102585440 cites W1982626583 @default.
• W2102585440 cites W1984332590 @default.
• W2102585440 cites W1989408149 @default.
• W2102585440 cites W1990360202 @default.
• W2102585440 cites W1994049323 @default.
• W2102585440 cites W1994210099 @default.
• W2102585440 cites W1996719664 @default.
• W2102585440 cites W2001617346 @default.
• W2102585440 cites W2002677862 @default.
• W2102585440 cites W2002945998 @default.
• W2102585440 cites W2008468980 @default.
• W2102585440 cites W2012932483 @default.
• W2102585440 cites W2014019173 @default.
• W2102585440 cites W2020285227 @default.
• W2102585440 cites W2026940024 @default.
• W2102585440 cites W2027562625 @default.
• W2102585440 cites W2029540049 @default.
• W2102585440 cites W2031450812 @default.
• W2102585440 cites W2033542738 @default.
• W2102585440 cites W2035126694 @default.
• W2102585440 cites W2035353809 @default.
• W2102585440 cites W2036740 @default.
• W2102585440 cites W2038970034 @default.
• W2102585440 cites W2040503240 @default.
• W2102585440 cites W2040814353 @default.
• W2102585440 cites W2042955019 @default.
• W2102585440 cites W2044820369 @default.
• W2102585440 cites W2044900010 @default.
• W2102585440 cites W2045051003 @default.
• W2102585440 cites W2045930312 @default.
• W2102585440 cites W2046500804 @default.
• W2102585440 cites W2046751682 @default.
• W2102585440 cites W2046870269 @default.
• W2102585440 cites W2047986475 @default.
• W2102585440 cites W2052176751 @default.
• W2102585440 cites W2052799735 @default.
• W2102585440 cites W2053738735 @default.
• W2102585440 cites W2054956235 @default.
• W2102585440 cites W2056317022 @default.
• W2102585440 cites W2057109596 @default.
• W2102585440 cites W2059476940 @default.
• W2102585440 cites W2063465629 @default.
• W2102585440 cites W2064692562 @default.
• W2102585440 cites W2065616590 @default.
• W2102585440 cites W2065765677 @default.
• W2102585440 cites W2067636449 @default.
• W2102585440 cites W2068502384 @default.
• W2102585440 cites W2070227288 @default.
• W2102585440 cites W2074714879 @default.
• W2102585440 cites W2076734328 @default.
• W2102585440 cites W2078317912 @default.
• W2102585440 cites W2079471342 @default.
• W2102585440 cites W2080985256 @default.
• W2102585440 cites W2085367294 @default.
• W2102585440 cites W2085381642 @default.
• W2102585440 cites W2087180130 @default.
• W2102585440 cites W2089285806 @default.
• W2102585440 cites W2090616036 @default.
• W2102585440 cites W2092292003 @default.
• W2102585440 cites W2094622809 @default.
• W2102585440 cites W2098999730 @default.
• W2102585440 cites W2101994642 @default.
• W2102585440 cites W2102850836 @default.
• W2102585440 cites W2107264775 @default.
• W2102585440 cites W2112566049 @default.
• W2102585440 cites W2114233759 @default.
• W2102585440 cites W2129778036 @default.
• W2102585440 cites W2136950115 @default.
• W2102585440 cites W2137665561 @default.
• W2102585440 cites W2139168999 @default.
• W2102585440 cites W2142461059 @default.

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