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• W2102596934 abstract "Summary1. Three classes of cytotoxic lymphocyte are discussed: thymus-derived T cells, antibody-dependent K cells and NK (natural killer) cells. Each of these cytotoxic lymphocytes has receptors allowing the formation of adhesions (contact) with a target cell (the cell to be killed). The type of receptor and the corresponding ligand on the target cell is different in each class. Cytotoxic T cells (and probably NK cells) react with a target cell antigen, in a manner rather like antibody-antigen reactions (although not involving classical serum antibody). K cells have a receptor for the Fc part of immunoglobulin (IgG) and hence can make contact with antibody-coated target cells.2. It seems likely that all three classes of cytotoxic lymphocyte have a similar basic mechanism of killing, which is different from the membrane leakage occurring in complement-mediated lysis. Much more information is available on cytotoxic T cells than on the other types of cell.3. Cytotoxic T cell killing can be divided into two phases. A reversible phase in which the T cell is in contact with the target cell, but causes no apparent damage. This phase can vary from a few minutes up to several hours, when a single T cell interacts with a single target cell. If the T cell detaches or is inactivated the target cell survives. The second phase is irreversible, once the lethal event has occurred, and the target cell will progress to eventual lysis in the absence of the Tc cells.4. The lethal event initiates a period of zeiosis (membrane blebbing) in the target cell, which is accompanied by increased effiux of 86rubidium. Cell lysis occurs at a variable time after the initiation of zeiosis, when the soluble contents of the cytoplasm burst out of the target cell. The fact that both these phases are of variable length leads to the accumulation of cytoplasmic markers (such as 51chromium) in the medium in an approximately linear fashion.5. The nature of the lethal event is unknown, but it is suggested that it involves changes inside the target cell rather than at the target cell membrane. Remarkable long projections from the T cell (and also seen from K cells and NK cells), apparently arising as a result of the receptor-ligand interaction, may be involved in the delivery of the lethal event." @default.
• W2102596934 created "2016-06-24" @default.
• W2102596934 creator A5048205568 @default.
• W2102596934 date "1981-05-01" @default.
• W2102596934 modified "2023-09-24" @default.
• W2102596934 title "THE MECHANISM OF LYMPHOCYTE-MEDIATED CYTOTOXICITY" @default.
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• W2102596934 doi "https://doi.org/10.1111/j.1469-185x.1981.tb00346.x" @default.
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