FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102600746> ?p ?o ?g. }

• W2102600746 endingPage "2297" @default.
• W2102600746 startingPage "2287" @default.
• W2102600746 abstract "β-Catenin has a key role in the formation of adherens junction through its interactions with E-cadherin and α-catenin. We show here that interaction of β-catenin with α-catenin is regulated by the phosphorylation of β-catenin Tyr-142. This residue can be phosphorylated in vitro by Fer or Fyn tyrosine kinases. Transfection of these kinases to epithelial cells disrupted the association between both catenins. We have also examined whether these kinases are involved in the regulation of this interaction by K-ras. Stable transfectants of the K-ras oncogene in intestinal epithelial IEC18 cells were generated which show little α-catenin-β-catenin association with respect to control clones; this effect is accompanied by increased Tyr-142 phosphorylation and activation of Fer and Fyn kinases. As reported for Fer, Fyn kinase is constitutively bound to p120 catenin; expression of K-ras induces the phosphorylation of p120 catenin on tyrosine residues increasing its affinity for E-cadherin and, consequently, promotes the association of Fyn with the adherens junction complex. Yes tyrosine kinase also binds to p120 catenin but only upon activation, and stimulates Fer and Fyn tyrosine kinases. These results indicate that p120 catenin acts as a docking protein facilitating the activation of Fer/Fyn tyrosine kinases by Yes and demonstrate the role of these p120 catenin-associated kinases in the regulation of β-catenin-α-catenin interaction." @default.
• W2102600746 created "2016-06-24" @default.
• W2102600746 creator A5000173747 @default.
• W2102600746 creator A5042874368 @default.
• W2102600746 creator A5043326504 @default.
• W2102600746 creator A5051864161 @default.
• W2102600746 creator A5063681799 @default.
• W2102600746 creator A5077589394 @default.
• W2102600746 creator A5091638379 @default.
• W2102600746 date "2003-04-01" @default.
• W2102600746 modified "2023-10-03" @default.
• W2102600746 title "p120 Catenin-Associated Fer and Fyn Tyrosine Kinases Regulate β-Catenin Tyr-142 Phosphorylation and β-Catenin-α-Catenin Interaction" @default.
• W2102600746 cites W1517441438 @default.
• W2102600746 cites W1953758512 @default.
• W2102600746 cites W1967113071 @default.
• W2102600746 cites W1967385749 @default.
• W2102600746 cites W1970193090 @default.
• W2102600746 cites W1972659626 @default.
• W2102600746 cites W1973466009 @default.
• W2102600746 cites W1989896581 @default.
• W2102600746 cites W1990215042 @default.
• W2102600746 cites W1998551458 @default.
• W2102600746 cites W1998776819 @default.
• W2102600746 cites W2010537141 @default.
• W2102600746 cites W2020504648 @default.
• W2102600746 cites W2021766527 @default.
• W2102600746 cites W2036053197 @default.
• W2102600746 cites W2039132486 @default.
• W2102600746 cites W2042610107 @default.
• W2102600746 cites W2045567387 @default.
• W2102600746 cites W2047392037 @default.
• W2102600746 cites W2055356631 @default.
• W2102600746 cites W2067606503 @default.
• W2102600746 cites W2070715920 @default.
• W2102600746 cites W2090481320 @default.
• W2102600746 cites W2091760428 @default.
• W2102600746 cites W2092127177 @default.
• W2102600746 cites W2093265249 @default.
• W2102600746 cites W2101257013 @default.
• W2102600746 cites W2108786117 @default.
• W2102600746 cites W2109016302 @default.
• W2102600746 cites W2116615268 @default.
• W2102600746 cites W2118252933 @default.
• W2102600746 cites W2119486893 @default.
• W2102600746 cites W2119593627 @default.
• W2102600746 cites W2122829982 @default.
• W2102600746 cites W2132888121 @default.
• W2102600746 cites W2134807546 @default.
• W2102600746 cites W2143578762 @default.
• W2102600746 cites W2143920497 @default.
• W2102600746 cites W2145617194 @default.
• W2102600746 cites W2163951902 @default.
• W2102600746 cites W2164590607 @default.
• W2102600746 cites W2182475970 @default.
• W2102600746 cites W2344860383 @default.
• W2102600746 doi "https://doi.org/10.1128/mcb.23.7.2287-2297.2003" @default.
• W2102600746 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/150740" @default.
• W2102600746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12640114" @default.
• W2102600746 hasPublicationYear "2003" @default.
• W2102600746 type Work @default.
• W2102600746 sameAs 2102600746 @default.
• W2102600746 citedByCount "316" @default.
• W2102600746 countsByYear W21026007462012 @default.
• W2102600746 countsByYear W21026007462013 @default.
• W2102600746 countsByYear W21026007462014 @default.
• W2102600746 countsByYear W21026007462015 @default.
• W2102600746 countsByYear W21026007462016 @default.
• W2102600746 countsByYear W21026007462017 @default.
• W2102600746 countsByYear W21026007462018 @default.
• W2102600746 countsByYear W21026007462019 @default.
• W2102600746 countsByYear W21026007462020 @default.
• W2102600746 countsByYear W21026007462021 @default.
• W2102600746 countsByYear W21026007462022 @default.
• W2102600746 countsByYear W21026007462023 @default.
• W2102600746 crossrefType "journal-article" @default.
• W2102600746 hasAuthorship W2102600746A5000173747 @default.
• W2102600746 hasAuthorship W2102600746A5042874368 @default.
• W2102600746 hasAuthorship W2102600746A5043326504 @default.
• W2102600746 hasAuthorship W2102600746A5051864161 @default.
• W2102600746 hasAuthorship W2102600746A5063681799 @default.
• W2102600746 hasAuthorship W2102600746A5077589394 @default.
• W2102600746 hasAuthorship W2102600746A5091638379 @default.
• W2102600746 hasBestOaLocation W21026007462 @default.
• W2102600746 hasConcept C101544691 @default.
• W2102600746 hasConcept C108636557 @default.
• W2102600746 hasConcept C11960822 @default.
• W2102600746 hasConcept C137620995 @default.
• W2102600746 hasConcept C1491633281 @default.
• W2102600746 hasConcept C149402561 @default.
• W2102600746 hasConcept C183141693 @default.
• W2102600746 hasConcept C184235292 @default.
• W2102600746 hasConcept C196347352 @default.
• W2102600746 hasConcept C201508349 @default.
• W2102600746 hasConcept C2776165026 @default.
• W2102600746 hasConcept C2777553839 @default.
• W2102600746 hasConcept C2779324961 @default.
• W2102600746 hasConcept C30145163 @default.
• W2102600746 hasConcept C37686147 @default.

• next