FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2102621836> ?p ?o ?g. }

• W2102621836 endingPage "2771" @default.
• W2102621836 startingPage "2759" @default.
• W2102621836 abstract "Abstract Protein acetylation, which is catalyzed by acetyltransferases, is a type of post‐translational modification and crucial to numerous essential biological processes, including transcriptional regulation, apoptosis, and cytokine signaling. As the experimental identification of protein acetylation sites is time consuming and laboratory intensive, several computational approaches have been developed for identifying the candidates of experimental validation. In this work, solvent accessibility and the physicochemical properties of proteins are utilized to identify acetylated alanine, glycine, lysine, methionine, serine, and threonine. A two‐stage support vector machine was applied to learn the computational models with combinations of amino acid sequences, and the accessible surface area and physicochemical properties of proteins. The predictive accuracy thus achieved is 5% to 14% higher than that of models trained using only amino acid sequences. Additionally, the substrate specificity of the acetylated site was investigated in detail with reference to the subcellular colocalization of acetyltransferases and acetylated proteins. The proposed method, N‐Ace, is evaluated using independent test sets in various acetylated residues and predictive accuracies of 90% were achieved, indicating that the performance of N‐Ace is comparable with that of other acetylation prediction methods. N‐Ace not only provides a user‐friendly input/output interface but also is a creative method for predicting protein acetylation sites. This novel analytical resource is now freely available at http://N‐Ace.mbc.NCTU.edu.tw/ . © 2010 Wiley Periodicals, Inc. J Comput Chem, 2010" @default.
• W2102621836 created "2016-06-24" @default.
• W2102621836 creator A5014125061 @default.
• W2102621836 creator A5022332905 @default.
• W2102621836 creator A5030196668 @default.
• W2102621836 creator A5043983948 @default.
• W2102621836 creator A5045675277 @default.
• W2102621836 creator A5065641887 @default.
• W2102621836 date "2010-09-08" @default.
• W2102621836 modified "2023-10-18" @default.
• W2102621836 title "N-Ace: Using solvent accessibility and physicochemical properties to identify protein N-acetylation sites" @default.
• W2102621836 cites W1480703691 @default.
• W2102621836 cites W1493846190 @default.
• W2102621836 cites W1510000497 @default.
• W2102621836 cites W1523466 @default.
• W2102621836 cites W1538162617 @default.
• W2102621836 cites W1971579210 @default.
• W2102621836 cites W1974793156 @default.
• W2102621836 cites W1975660840 @default.
• W2102621836 cites W1975692560 @default.
• W2102621836 cites W1977927254 @default.
• W2102621836 cites W1982545065 @default.
• W2102621836 cites W2005116846 @default.
• W2102621836 cites W2006916011 @default.
• W2102621836 cites W2014766736 @default.
• W2102621836 cites W2017204495 @default.
• W2102621836 cites W2017324120 @default.
• W2102621836 cites W2023919356 @default.
• W2102621836 cites W2041877620 @default.
• W2102621836 cites W2043338013 @default.
• W2102621836 cites W2051152566 @default.
• W2102621836 cites W2052837845 @default.
• W2102621836 cites W2062804020 @default.
• W2102621836 cites W2069392850 @default.
• W2102621836 cites W2072603644 @default.
• W2102621836 cites W2077180950 @default.
• W2102621836 cites W2086882324 @default.
• W2102621836 cites W2088522769 @default.
• W2102621836 cites W2093931104 @default.
• W2102621836 cites W2098376021 @default.
• W2102621836 cites W2101979121 @default.
• W2102621836 cites W2104813013 @default.
• W2102621836 cites W2106413110 @default.
• W2102621836 cites W2111705855 @default.
• W2102621836 cites W2113623846 @default.
• W2102621836 cites W2120026469 @default.
• W2102621836 cites W2121417968 @default.
• W2102621836 cites W2128538135 @default.
• W2102621836 cites W2129137060 @default.
• W2102621836 cites W2142479026 @default.
• W2102621836 cites W2143197682 @default.
• W2102621836 cites W2148853951 @default.
• W2102621836 cites W2156712995 @default.
• W2102621836 cites W2158266834 @default.
• W2102621836 cites W2159199134 @default.
• W2102621836 cites W2171742422 @default.
• W2102621836 cites W4239620712 @default.
• W2102621836 doi "https://doi.org/10.1002/jcc.21569" @default.
• W2102621836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20839302" @default.
• W2102621836 hasPublicationYear "2010" @default.
• W2102621836 type Work @default.
• W2102621836 sameAs 2102621836 @default.
• W2102621836 citedByCount "48" @default.
• W2102621836 countsByYear W21026218362012 @default.
• W2102621836 countsByYear W21026218362013 @default.
• W2102621836 countsByYear W21026218362014 @default.
• W2102621836 countsByYear W21026218362015 @default.
• W2102621836 countsByYear W21026218362016 @default.
• W2102621836 countsByYear W21026218362017 @default.
• W2102621836 countsByYear W21026218362018 @default.
• W2102621836 countsByYear W21026218362019 @default.
• W2102621836 countsByYear W21026218362020 @default.
• W2102621836 countsByYear W21026218362021 @default.
• W2102621836 countsByYear W21026218362022 @default.
• W2102621836 countsByYear W21026218362023 @default.
• W2102621836 crossrefType "journal-article" @default.
• W2102621836 hasAuthorship W2102621836A5014125061 @default.
• W2102621836 hasAuthorship W2102621836A5022332905 @default.
• W2102621836 hasAuthorship W2102621836A5030196668 @default.
• W2102621836 hasAuthorship W2102621836A5043983948 @default.
• W2102621836 hasAuthorship W2102621836A5045675277 @default.
• W2102621836 hasAuthorship W2102621836A5065641887 @default.
• W2102621836 hasBestOaLocation W21026218362 @default.
• W2102621836 hasConcept C104317684 @default.
• W2102621836 hasConcept C11072593 @default.
• W2102621836 hasConcept C119157956 @default.
• W2102621836 hasConcept C181199279 @default.
• W2102621836 hasConcept C185592680 @default.
• W2102621836 hasConcept C2775880066 @default.
• W2102621836 hasConcept C2776016237 @default.
• W2102621836 hasConcept C2776414213 @default.
• W2102621836 hasConcept C515207424 @default.
• W2102621836 hasConcept C55493867 @default.
• W2102621836 hasConcept C70721500 @default.
• W2102621836 hasConcept C86803240 @default.
• W2102621836 hasConceptScore W2102621836C104317684 @default.
• W2102621836 hasConceptScore W2102621836C11072593 @default.
• W2102621836 hasConceptScore W2102621836C119157956 @default.

• next